L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Identifieur interne : 000605 ( PubMed/Curation ); précédent : 000604; suivant : 000606L-dopa-induced dyskinesia: beyond an excessive dopamine tone in the striatum.
Auteurs : Gregory Porras [Royaume-Uni] ; Philippe De Deurwaerdere [France] ; Qin Li [République populaire de Chine] ; Matteo Marti [Italie] ; Rudolf Morgenstern [Allemagne] ; Reinhard Sohr [Allemagne] ; Erwan Bezard [France] ; Michele Morari [Italie] ; Wassilios G. Meissner [France]Source :
- Scientific reports [ 2045-2322 ] ; 2014.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (adverse effects), Animals, Benserazide (adverse effects), Benserazide (pharmacokinetics), Corpus Striatum (drug effects), Corpus Striatum (metabolism), Disease Models, Animal, Dopamine (metabolism), Dopamine Agents (adverse effects), Dopamine Agents (pharmacokinetics), Drug Combinations, Dyskinesias (etiology), Dyskinesias (metabolism), Female, Levodopa (adverse effects), Levodopa (pharmacokinetics), Macaca mulatta, Male, Parkinson Disease (metabolism).
- MESH :
- chemical , adverse effects : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Benserazide, Dopamine Agents, Levodopa.
- chemical , metabolism : Dopamine.
- chemical , pharmacokinetics : Benserazide, Dopamine Agents, Levodopa.
- drug effects : Corpus Striatum.
- etiology : Dyskinesias.
- metabolism : Corpus Striatum, Dyskinesias, Parkinson Disease.
- Animals, Disease Models, Animal, Drug Combinations, Female, Macaca mulatta, Male.
Abstract
L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa.
DOI: 10.1038/srep03730
PubMed: 24429495
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pubmed:24429495Le document en format XML
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<front><div type="abstract" xml:lang="en">L-dopa remains the mainstay treatment for Parkinson's disease (PD), although in later stages, treatment is complicated by L-dopa-induced dyskinesias (LID). Current evidence links LID to excessive striatal L-dopa-derived dopamine (DA) release, while the possibility of a direct involvement of L-dopa itself in LID has been largely ignored. Here we show that L-dopa can alter basal ganglia activity and produce LID without enhancing striatal DA release in parkinsonian non-human primates. These data may have therapeutic implications for the management of advanced PD since they suggest that LID could result from diverse mechanisms of action of L-dopa.</div>
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