Emergence of restless legs syndrome after subthalamic stimulation in Parkinson's disease: a dopaminergic overstimulation?
Identifieur interne : 000360 ( PubMed/Curation ); précédent : 000359; suivant : 000361Emergence of restless legs syndrome after subthalamic stimulation in Parkinson's disease: a dopaminergic overstimulation?
Auteurs : Ana Marques [France] ; Maria Livia Fantini [France] ; Dominique Morand [France] ; Bruno Pereira [France] ; Philippe Derost [France] ; Miguel Ulla [France] ; Bérengère Debilly [France] ; Jean-Jacques Lemaire [France] ; Franck Durif [France]Source :
- Sleep medicine [ 1878-5506 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (administration & dosage), Antiparkinson Agents (therapeutic use), Deep Brain Stimulation (adverse effects), Deep Brain Stimulation (methods), Dopaminergic Neurons (drug effects), Dopaminergic Neurons (physiology), Female, Humans, Levodopa (administration & dosage), Levodopa (therapeutic use), Male, Middle Aged, Parkinson Disease (drug therapy), Parkinson Disease (therapy), Prospective Studies, Restless Legs Syndrome (etiology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology).
- MESH :
- chemical , administration & dosage : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- adverse effects : Deep Brain Stimulation.
- drug effects : Dopaminergic Neurons, Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- etiology : Restless Legs Syndrome.
- methods : Deep Brain Stimulation.
- physiology : Dopaminergic Neurons.
- physiopathology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Prospective Studies.
Abstract
Studies investigating the effects of subthalamic deep-brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) are limited and report conflicting results, with some describing the emergence of RLS after DBS-STN, while others report postoperative improvement of this disorder. Severe decrease in postoperative dopaminergic medications dose, which may unmask RLS symptoms, has been proposed to explain the emergence of RLS after surgery. We aimed to specifically identify factors associated with the risk of developing RLS after DBS-STN in order to enhance our comprehension of the underlying mechanisms contributing to the development of RLS in PD.
DOI: 10.1016/j.sleep.2014.11.020
PubMed: 25881920
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pubmed:25881920Le document en format XML
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<term>Levodopa (therapeutic use)</term>
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<term>Parkinson Disease (therapy)</term>
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<front><div type="abstract" xml:lang="en">Studies investigating the effects of subthalamic deep-brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) are limited and report conflicting results, with some describing the emergence of RLS after DBS-STN, while others report postoperative improvement of this disorder. Severe decrease in postoperative dopaminergic medications dose, which may unmask RLS symptoms, has been proposed to explain the emergence of RLS after surgery. We aimed to specifically identify factors associated with the risk of developing RLS after DBS-STN in order to enhance our comprehension of the underlying mechanisms contributing to the development of RLS in PD.</div>
</front>
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<Month>05</Month>
<Day>08</Day>
</DateCreated>
<DateCompleted><Year>2016</Year>
<Month>04</Month>
<Day>25</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>05</Month>
<Day>08</Day>
</DateRevised>
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<JournalIssue CitedMedium="Internet"><Volume>16</Volume>
<Issue>5</Issue>
<PubDate><Year>2015</Year>
<Month>May</Month>
</PubDate>
</JournalIssue>
<Title>Sleep medicine</Title>
<ISOAbbreviation>Sleep Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Emergence of restless legs syndrome after subthalamic stimulation in Parkinson's disease: a dopaminergic overstimulation?</ArticleTitle>
<Pagination><MedlinePgn>583-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.sleep.2014.11.020</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1389-9457(15)00093-3</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Studies investigating the effects of subthalamic deep-brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) are limited and report conflicting results, with some describing the emergence of RLS after DBS-STN, while others report postoperative improvement of this disorder. Severe decrease in postoperative dopaminergic medications dose, which may unmask RLS symptoms, has been proposed to explain the emergence of RLS after surgery. We aimed to specifically identify factors associated with the risk of developing RLS after DBS-STN in order to enhance our comprehension of the underlying mechanisms contributing to the development of RLS in PD.</AbstractText>
<AbstractText Label="PATIENTS" NlmCategory="METHODS">In this observational prospective study, we evaluated the occurrence of RLS in 31 patients with PD originally free from RLS symptoms, six months after bilateral chronic DBS-STN, and compared clinical and treatment parameters of patients who developed postoperative RLS with those of patients without postoperative RLS.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Six patients out of 31 reported post-operative emergence of RLS. There was no between-group difference in demographic data, pre-operative treatment parameters or clinical improvement measures after DBS-STN. However, PD patients with emergence of RLS after DBS-STN had a higher dose of dopamine agonists at postoperative evaluation compared to PD patients without emergence of RLS (p = 0.040) and a lower percentage of decrease in dopamine agonists (p = 0.043).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Overstimulation resulting from cumulative effects of dopamine agonists and STN-DBS may induce changes in excitability of the dopaminergic system, leading to an emergence of RLS. Clinicians should take into account this phenomenon while adjusting pharmacological treatment after surgery.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Marques</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Neurology Department, CHU Clermont-Ferrand, F-63001 Clermont-Ferrand, France; UFR Medicine, University Clermont 1, EA 7280, F-63001 Clermont-Ferrand, France. Electronic address: ar_marques@chu-clermontferrand.fr.</Affiliation>
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<Author ValidYN="Y"><LastName>Fantini</LastName>
<ForeName>Maria Livia</ForeName>
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<AffiliationInfo><Affiliation>UFR Medicine, University Clermont 1, EA 7280, F-63001 Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
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<ForeName>Dominique</ForeName>
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<ForeName>Philippe</ForeName>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Ulla</LastName>
<ForeName>Miguel</ForeName>
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</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Debilly</LastName>
<ForeName>Bérengère</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Neurology Department, CHU Clermont-Ferrand, F-63001 Clermont-Ferrand, France; UFR Medicine, University Clermont 1, EA 7280, F-63001 Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lemaire</LastName>
<ForeName>Jean-Jacques</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Neurosurgery Department, CHU Clermont-Ferrand, F-63001 Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Durif</LastName>
<ForeName>Franck</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Neurology Department, CHU Clermont-Ferrand, F-63001 Clermont-Ferrand, France; UFR Medicine, University Clermont 1, EA 7280, F-63001 Clermont-Ferrand, France.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<PublicationType UI="D064888">Observational Study</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>03</Month>
<Day>03</Day>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Deep brain stimulation</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
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<Day>28</Day>
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<PubMedPubDate PubStatus="revised"><Year>2014</Year>
<Month>11</Month>
<Day>13</Day>
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