Closed-loop stimulation of a delayed neural fields model of parkinsonian STN-GPe network: a theoretical and computational study.
Identifieur interne : 000324 ( PubMed/Curation ); précédent : 000323; suivant : 000325Closed-loop stimulation of a delayed neural fields model of parkinsonian STN-GPe network: a theoretical and computational study.
Auteurs : Georgios Is Detorakis [France] ; Antoine Chaillet [France] ; Stéphane Palfi [France] ; Suhan Senova [France]Source :
- Frontiers in neuroscience [ 1662-4548 ] ; 2015.
Abstract
Several disorders are related to pathological brain oscillations. In the case of Parkinson's disease, sustained low-frequency oscillations (especially in the β-band, 13-30 Hz) correlate with motor symptoms. It is still under debate whether these oscillations are the cause of parkinsonian motor symptoms. The development of techniques enabling selective disruption of these β-oscillations could contribute to the understanding of the underlying mechanisms, and could be exploited for treatments. A particularly appealing technique is Deep Brain Stimulation (DBS). With clinical electrical DBS, electrical currents are delivered at high frequency to a region made of potentially heterogeneous neurons (the subthalamic nucleus (STN) in the case of Parkinson's disease). Even more appealing is DBS with optogenetics, which is until now a preclinical method using both gene transfer and deep brain light delivery and enabling neuromodulation at the scale of one given neural network. In this work, we rely on delayed neural fields models of STN and the external Globus Pallidus (GPe) to develop, theoretically validate and test in silico a closed-loop stimulation strategy to disrupt these sustained oscillations with optogenetics. First, we rely on tools from control theory to provide theoretical conditions under which sustained oscillations can be attenuated by a closed-loop stimulation proportional to the measured activity of STN. Second, based on this theoretical framework, we show numerically that the proposed closed-loop stimulation efficiently attenuates sustained oscillations, even in the case when the photosensitization effectively affects only 50% of STN neurons. We also show through simulations that oscillations disruption can be achieved when the same light source is used for the whole STN population. We finally test the robustness of the proposed strategy to possible acquisition and processing delays, as well as parameters uncertainty.
DOI: 10.3389/fnins.2015.00237
PubMed: 26217171
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Mondor, Service de neurochirurgie Créteil, France ; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 14 Créteil, France ; Faculty of Medicine, Université Paris Est Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hospital H. Mondor, Service de neurochirurgie Créteil, France ; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 14 Créteil, France ; Faculty of Medicine, Université Paris Est Créteil</wicri:regionArea></affiliation></author><author><name sortKey="Senova, Suhan" sort="Senova, Suhan" uniqKey="Senova S" first="Suhan" last="Senova">Suhan Senova</name><affiliation wicri:level="1"><nlm:affiliation>AP-HP, Hospital H. Mondor, Service de neurochirurgie Créteil, France ; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 14 Créteil, France ; Faculty of Medicine, Université Paris Est Créteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>AP-HP, Hospital H. Mondor, Service de neurochirurgie Créteil, France ; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 14 Créteil, France ; Faculty of Medicine, Université Paris Est Créteil</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in neuroscience</title><idno type="ISSN">1662-4548</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several disorders are related to pathological brain oscillations. In the case of Parkinson's disease, sustained low-frequency oscillations (especially in the β-band, 13-30 Hz) correlate with motor symptoms. It is still under debate whether these oscillations are the cause of parkinsonian motor symptoms. The development of techniques enabling selective disruption of these β-oscillations could contribute to the understanding of the underlying mechanisms, and could be exploited for treatments. A particularly appealing technique is Deep Brain Stimulation (DBS). With clinical electrical DBS, electrical currents are delivered at high frequency to a region made of potentially heterogeneous neurons (the subthalamic nucleus (STN) in the case of Parkinson's disease). Even more appealing is DBS with optogenetics, which is until now a preclinical method using both gene transfer and deep brain light delivery and enabling neuromodulation at the scale of one given neural network. In this work, we rely on delayed neural fields models of STN and the external Globus Pallidus (GPe) to develop, theoretically validate and test in silico a closed-loop stimulation strategy to disrupt these sustained oscillations with optogenetics. First, we rely on tools from control theory to provide theoretical conditions under which sustained oscillations can be attenuated by a closed-loop stimulation proportional to the measured activity of STN. Second, based on this theoretical framework, we show numerically that the proposed closed-loop stimulation efficiently attenuates sustained oscillations, even in the case when the photosensitization effectively affects only 50% of STN neurons. We also show through simulations that oscillations disruption can be achieved when the same light source is used for the whole STN population. 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In the case of Parkinson's disease, sustained low-frequency oscillations (especially in the β-band, 13-30 Hz) correlate with motor symptoms. It is still under debate whether these oscillations are the cause of parkinsonian motor symptoms. The development of techniques enabling selective disruption of these β-oscillations could contribute to the understanding of the underlying mechanisms, and could be exploited for treatments. A particularly appealing technique is Deep Brain Stimulation (DBS). With clinical electrical DBS, electrical currents are delivered at high frequency to a region made of potentially heterogeneous neurons (the subthalamic nucleus (STN) in the case of Parkinson's disease). Even more appealing is DBS with optogenetics, which is until now a preclinical method using both gene transfer and deep brain light delivery and enabling neuromodulation at the scale of one given neural network. In this work, we rely on delayed neural fields models of STN and the external Globus Pallidus (GPe) to develop, theoretically validate and test in silico a closed-loop stimulation strategy to disrupt these sustained oscillations with optogenetics. First, we rely on tools from control theory to provide theoretical conditions under which sustained oscillations can be attenuated by a closed-loop stimulation proportional to the measured activity of STN. Second, based on this theoretical framework, we show numerically that the proposed closed-loop stimulation efficiently attenuates sustained oscillations, even in the case when the photosensitization effectively affects only 50% of STN neurons. We also show through simulations that oscillations disruption can be achieved when the same light source is used for the whole STN population. We finally test the robustness of the proposed strategy to possible acquisition and processing delays, as well as parameters uncertainty.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Detorakis</LastName><ForeName>Georgios Is</ForeName><Initials>GI</Initials><AffiliationInfo><Affiliation>Laboratoire des Signaux et Systèmes, CentraleSupelec Gif-sur-Yvette, France ; Faculté des Sciences, Université Paris Sud Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaillet</LastName><ForeName>Antoine</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratoire des Signaux et Systèmes, CentraleSupelec Gif-sur-Yvette, France ; Faculté des Sciences, Université Paris Sud Orsay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palfi</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>AP-HP, Hospital H. Mondor, Service de neurochirurgie Créteil, France ; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 14 Créteil, France ; Faculty of Medicine, Université Paris Est Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senova</LastName><ForeName>Suhan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>AP-HP, Hospital H. Mondor, Service de neurochirurgie Créteil, France ; Institut National de la Santé et de la Recherche Médicale, U955, Equipe 14 Créteil, France ; Faculty of Medicine, Université Paris Est Créteil, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>07</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Neurosci</MedlineTA><NlmUniqueID>101478481</NlmUniqueID><ISSNLinking>1662-453X</ISSNLinking></MedlineJournalInfo><OtherID Source="NLM">PMC4498106</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">closed-loop deep brain stimulation</Keyword><Keyword MajorTopicYN="N">control theory</Keyword><Keyword MajorTopicYN="N">delayed neural fields</Keyword><Keyword MajorTopicYN="N">optogenetics</Keyword><Keyword MajorTopicYN="N">stability analysis</Keyword><Keyword MajorTopicYN="N">β-oscillations</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>06</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>29</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26217171</ArticleId><ArticleId IdType="doi">10.3389/fnins.2015.00237</ArticleId><ArticleId IdType="pmc">PMC4498106</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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