Why bother using non-human primate models of cognitive disorders in translational research?
Identifieur interne : 000288 ( PubMed/Curation ); précédent : 000287; suivant : 000289Why bother using non-human primate models of cognitive disorders in translational research?
Auteurs : Sandrine Camus [Royaume-Uni] ; Wai Kin D. Ko [Royaume-Uni] ; Elsa Pioli [Royaume-Uni] ; Erwan Bezard [France]Source :
- Neurobiology of learning and memory [ 1095-9564 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- genetics : Cognition Disorders.
- methods : Translational Medical Research.
- physiopathology : Alzheimer Disease, Brain, Cognition Disorders, Parkinson Disease.
- Animals, Disease Models, Animal, Humans, Macaca, Primates, Species Specificity.
Abstract
Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp models. In this review, we discuss the importance of nhps in translational research, highlighting the advances in technological/methodological approaches for 'bridging the gap' between preclinical and clinical experiments. In this process, we acknowledge that nhps remain a vital tool for the investigation of complex cognitive functions, given their resemblance to humans in aspects of behaviour, anatomy and physiology. The recent improvements made for a suitable nhp model in cognitive research, including new surrogates of disease and application of innovative methodological approaches, are continuous strides for reaching efficient translation for human benefit. This will ultimately aid the development of innovative treatments against the current and future threat of neurological and psychiatric disorders to the global population.
DOI: 10.1016/j.nlm.2015.06.012
PubMed: 26135120
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Ko</name><affiliation wicri:level="1"><nlm:affiliation>Motac Neuroscience Ltd, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Motac Neuroscience Ltd, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Pioli, Elsa" sort="Pioli, Elsa" uniqKey="Pioli E" first="Elsa" last="Pioli">Elsa Pioli</name><affiliation wicri:level="1"><nlm:affiliation>Motac Neuroscience Ltd, Manchester, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Motac Neuroscience Ltd, Manchester</wicri:regionArea></affiliation></author><author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name><affiliation wicri:level="1"><nlm:affiliation>Motac Neuroscience Ltd, Manchester, United Kingdom; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Motac Neuroscience Ltd, Manchester, United Kingdom; Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France; CNRS, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neurobiology of learning and memory</title><idno type="eISSN">1095-9564</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (physiopathology)</term><term>Animals</term><term>Brain (physiopathology)</term><term>Cognition Disorders (genetics)</term><term>Cognition Disorders (physiopathology)</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca</term><term>Parkinson Disease (physiopathology)</term><term>Primates</term><term>Species Specificity</term><term>Translational Medical Research (methods)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Translational Medical Research</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Brain</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca</term><term>Primates</term><term>Species Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp models. In this review, we discuss the importance of nhps in translational research, highlighting the advances in technological/methodological approaches for 'bridging the gap' between preclinical and clinical experiments. In this process, we acknowledge that nhps remain a vital tool for the investigation of complex cognitive functions, given their resemblance to humans in aspects of behaviour, anatomy and physiology. The recent improvements made for a suitable nhp model in cognitive research, including new surrogates of disease and application of innovative methodological approaches, are continuous strides for reaching efficient translation for human benefit. This will ultimately aid the development of innovative treatments against the current and future threat of neurological and psychiatric disorders to the global population.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26135120</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>12</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>09</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>12</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9564</ISSN><JournalIssue CitedMedium="Internet"><Volume>124</Volume><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Neurobiology of learning and memory</Title><ISOAbbreviation>Neurobiol Learn Mem</ISOAbbreviation></Journal><ArticleTitle>Why bother using non-human primate models of cognitive disorders in translational research?</ArticleTitle><Pagination><MedlinePgn>123-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.nlm.2015.06.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1074-7427(15)00118-5</ELocationID><Abstract><AbstractText>Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp models. In this review, we discuss the importance of nhps in translational research, highlighting the advances in technological/methodological approaches for 'bridging the gap' between preclinical and clinical experiments. In this process, we acknowledge that nhps remain a vital tool for the investigation of complex cognitive functions, given their resemblance to humans in aspects of behaviour, anatomy and physiology. The recent improvements made for a suitable nhp model in cognitive research, including new surrogates of disease and application of innovative methodological approaches, are continuous strides for reaching efficient translation for human benefit. This will ultimately aid the development of innovative treatments against the current and future threat of neurological and psychiatric disorders to the global population.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. 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