Emotional manifestations of PD: Neurobiological basis.
Identifieur interne : 000111 ( PubMed/Curation ); précédent : 000110; suivant : 000112Emotional manifestations of PD: Neurobiological basis.
Auteurs : Anna Castrioto [France] ; Stéphane Thobois [France] ; Sebastien Carnicella [France] ; Audrey Maillet [France] ; Paul Krack [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
Neuropsychiatric symptoms are common and disabling in PD. Their neurobiological bases are complex, partly because of the disease itself and partly because of the dopaminergic treatment. The aim of this review is to focus on the emotional manifestations stemming from the neurodegenerative process itself. We focus on depression, anxiety, apathy, and fatigue, which can all be part of the clinical spectrum of premotor disease and may be improved or masked by medications targeting parkinsonian motor signs or psychiatric symptoms as the disease progresses. Findings from clinical, neuroimaging, and animal studies are reviewed, showing a major contribution of the dopaminergic system to the pathophysiology of these disabling symptoms. Degeneration of noradrenergic and serotonergic projection systems also has an impact on psychiatric symptoms of PD. The available literature is reviewed, but at present there is a lack of studies that would allow disentangling the separate contribution of each of the monoaminergic systems. The use of a pragmatic classification of all these symptoms under the umbrella of hypodopaminergic behavioral syndrome seems clinically useful, as it emphasizes the crucial, although not exclusive, nature of their dopaminergic neurobiological basis, which has important implications in the clinical management of PD. © 2016 International Parkinson and Movement Disorder Society.
DOI: 10.1002/mds.26587
PubMed: 27041545
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000111
Links to Exploration step
pubmed:27041545Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emotional manifestations of PD: Neurobiological basis.</title>
<author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name>
<affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carnicella, Sebastien" sort="Carnicella, Sebastien" uniqKey="Carnicella S" first="Sebastien" last="Carnicella">Sebastien Carnicella</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maillet, Audrey" sort="Maillet, Audrey" uniqKey="Maillet A" first="Audrey" last="Maillet">Audrey Maillet</name>
<affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27041545</idno>
<idno type="pmid">27041545</idno>
<idno type="doi">10.1002/mds.26587</idno>
<idno type="wicri:Area/PubMed/Corpus">000111</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000111</idno>
<idno type="wicri:Area/PubMed/Curation">000111</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000111</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Emotional manifestations of PD: Neurobiological basis.</title>
<author><name sortKey="Castrioto, Anna" sort="Castrioto, Anna" uniqKey="Castrioto A" first="Anna" last="Castrioto">Anna Castrioto</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name>
<affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Carnicella, Sebastien" sort="Carnicella, Sebastien" uniqKey="Carnicella S" first="Sebastien" last="Carnicella">Sebastien Carnicella</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maillet, Audrey" sort="Maillet, Audrey" uniqKey="Maillet A" first="Audrey" last="Maillet">Audrey Maillet</name>
<affiliation wicri:level="1"><nlm:affiliation>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name>
<affiliation wicri:level="1"><nlm:affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title>
<idno type="eISSN">1531-8257</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Neuropsychiatric symptoms are common and disabling in PD. Their neurobiological bases are complex, partly because of the disease itself and partly because of the dopaminergic treatment. The aim of this review is to focus on the emotional manifestations stemming from the neurodegenerative process itself. We focus on depression, anxiety, apathy, and fatigue, which can all be part of the clinical spectrum of premotor disease and may be improved or masked by medications targeting parkinsonian motor signs or psychiatric symptoms as the disease progresses. Findings from clinical, neuroimaging, and animal studies are reviewed, showing a major contribution of the dopaminergic system to the pathophysiology of these disabling symptoms. Degeneration of noradrenergic and serotonergic projection systems also has an impact on psychiatric symptoms of PD. The available literature is reviewed, but at present there is a lack of studies that would allow disentangling the separate contribution of each of the monoaminergic systems. The use of a pragmatic classification of all these symptoms under the umbrella of hypodopaminergic behavioral syndrome seems clinically useful, as it emphasizes the crucial, although not exclusive, nature of their dopaminergic neurobiological basis, which has important implications in the clinical management of PD. © 2016 International Parkinson and Movement Disorder Society.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27041545</PMID>
<DateCreated><Year>2016</Year>
<Month>08</Month>
<Day>10</Day>
</DateCreated>
<DateRevised><Year>2016</Year>
<Month>08</Month>
<Day>10</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>31</Volume>
<Issue>8</Issue>
<PubDate><Year>2016</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Movement disorders : official journal of the Movement Disorder Society</Title>
<ISOAbbreviation>Mov. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Emotional manifestations of PD: Neurobiological basis.</ArticleTitle>
<Pagination><MedlinePgn>1103-13</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26587</ELocationID>
<Abstract><AbstractText>Neuropsychiatric symptoms are common and disabling in PD. Their neurobiological bases are complex, partly because of the disease itself and partly because of the dopaminergic treatment. The aim of this review is to focus on the emotional manifestations stemming from the neurodegenerative process itself. We focus on depression, anxiety, apathy, and fatigue, which can all be part of the clinical spectrum of premotor disease and may be improved or masked by medications targeting parkinsonian motor signs or psychiatric symptoms as the disease progresses. Findings from clinical, neuroimaging, and animal studies are reviewed, showing a major contribution of the dopaminergic system to the pathophysiology of these disabling symptoms. Degeneration of noradrenergic and serotonergic projection systems also has an impact on psychiatric symptoms of PD. The available literature is reviewed, but at present there is a lack of studies that would allow disentangling the separate contribution of each of the monoaminergic systems. The use of a pragmatic classification of all these symptoms under the umbrella of hypodopaminergic behavioral syndrome seems clinically useful, as it emphasizes the crucial, although not exclusive, nature of their dopaminergic neurobiological basis, which has important implications in the clinical management of PD. © 2016 International Parkinson and Movement Disorder Society.</AbstractText>
<CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Castrioto</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U1216, Grenoble, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Movement Disorders Unit, Neurology Department, CHU de Grenoble, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Thobois</LastName>
<ForeName>Stéphane</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Hospices Civils de Lyon, Hôpital Neurologique, Neurologie C; Université Lyon I, Faculté de Médecine et de Maïeutique Lyon Sud Charles Mérieux, Lyon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carnicella</LastName>
<ForeName>Sebastien</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U1216, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maillet</LastName>
<ForeName>Audrey</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>CNRS, UMR 5229, Centre de Neurosciences Cognitives, Bron, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Krack</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Univ. Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, Grenoble, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Inserm, U1216, Grenoble, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Movement Disorders Unit, Neurology Department, CHU de Grenoble, Grenoble, France.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>04</Month>
<Day>04</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Mov Disord</MedlineTA>
<NlmUniqueID>8610688</NlmUniqueID>
<ISSNLinking>0885-3185</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Parkinson's disease</Keyword>
<Keyword MajorTopicYN="N">anxiety</Keyword>
<Keyword MajorTopicYN="N">apathy</Keyword>
<Keyword MajorTopicYN="N">depression</Keyword>
<Keyword MajorTopicYN="N">dopamine</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>10</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>01</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>01</Month>
<Day>24</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>4</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27041545</ArticleId>
<ArticleId IdType="doi">10.1002/mds.26587</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000111 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd -nk 000111 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Curation |type= RBID |clé= pubmed:27041545 |texte= Emotional manifestations of PD: Neurobiological basis. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Curation/RBID.i -Sk "pubmed:27041545" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |