Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait.
Identifieur interne : 000096 ( PubMed/Curation ); précédent : 000095; suivant : 000097Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait.
Auteurs : Vanessa Fleury [Suisse] ; Pierre Pollak [Suisse] ; Julien Gere [France] ; Giorgio Tommasi [France] ; Luigi Romito [France] ; Christophe Combescure [Suisse] ; Eric Bardinet [France] ; Stephan Chabardes [France] ; Shahan Momjian [Suisse] ; Alexandre Krainik [France] ; Pierre Burkhard [Suisse] ; Jérôme Yelnik [France] ; Paul Krack [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2016.
Abstract
Gait and akinesia deterioration in PD patients during the immediate postoperative period of DBS has been directly related to stimulation in the subthalamic region. The underlying mechanisms remain poorly understood. The aim of the present study was to clinically and anatomically describe this side effect.
DOI: 10.1002/mds.26545
PubMed: 26887333
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uniqKey="Fleury V" first="Vanessa" last="Fleury">Vanessa Fleury</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Geneva University Hospital, Geneva, Switzerland. Vanessa.FleuryNissen@hcuge.ch.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospital, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Geneva University Hospital, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospital, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Gere, Julien" sort="Gere, Julien" uniqKey="Gere J" first="Julien" last="Gere">Julien Gere</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Tommasi, Giorgio" sort="Tommasi, Giorgio" uniqKey="Tommasi G" first="Giorgio" last="Tommasi">Giorgio Tommasi</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Combescure, Christophe" sort="Combescure, Christophe" uniqKey="Combescure C" first="Christophe" last="Combescure">Christophe Combescure</name><affiliation wicri:level="1"><nlm:affiliation>Department of Health and Community Medicine, Geneva University Hospital, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Health and Community Medicine, Geneva University Hospital, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Bardinet, Eric" sort="Bardinet, Eric" uniqKey="Bardinet E" first="Eric" last="Bardinet">Eric Bardinet</name><affiliation wicri:level="1"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris, Inserm U975, CNRS UMR 7225, Centre de Neuroimagerie de Recherche, Institut du Cerveau et de la Moelle Épinière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Université, UPMC Univ Paris, Inserm U975, CNRS UMR 7225, Centre de Neuroimagerie de Recherche, Institut du Cerveau et de la Moelle Épinière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardes">Stephan Chabardes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurosurgery, Grenoble University Hospital, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Momjian, Shahan" sort="Momjian, Shahan" uniqKey="Momjian S" first="Shahan" last="Momjian">Shahan Momjian</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurosurgery, Geneva University Hospital, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurosurgery, Geneva University Hospital, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Krainik, Alexandre" sort="Krainik, Alexandre" uniqKey="Krainik A" first="Alexandre" last="Krainik">Alexandre Krainik</name><affiliation wicri:level="1"><nlm:affiliation>US 017, INSERM, UMS 3552, CNRS, Grenoble University Hospital, Neuroradiology and MRI, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>US 017, INSERM, UMS 3552, CNRS, Grenoble University Hospital, Neuroradiology and MRI, Grenoble</wicri:regionArea></affiliation></author><author><name sortKey="Burkhard, Pierre" sort="Burkhard, Pierre" uniqKey="Burkhard P" first="Pierre" last="Burkhard">Pierre Burkhard</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Geneva University Hospital, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology, Geneva University Hospital, Geneva</wicri:regionArea></affiliation></author><author><name sortKey="Yelnik, Jerome" sort="Yelnik, Jerome" uniqKey="Yelnik J" first="Jérôme" last="Yelnik">Jérôme Yelnik</name><affiliation wicri:level="1"><nlm:affiliation>Sorbonne Université, UPMC Univ Paris, Inserm U975, CNRS UMR 7225, Centre de Neuroimagerie de Recherche, Institut du Cerveau et de la Moelle Épinière, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Université, UPMC Univ Paris, Inserm U975, CNRS UMR 7225, Centre de Neuroimagerie de Recherche, Institut du Cerveau et de la Moelle Épinière, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble</wicri:regionArea></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gait and akinesia deterioration in PD patients during the immediate postoperative period of DBS has been directly related to stimulation in the subthalamic region. The underlying mechanisms remain poorly understood. The aim of the present study was to clinically and anatomically describe this side effect.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">26887333</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>07</Day></DateCreated><DateRevised><Year>2016</Year><Month>09</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>9</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Subthalamic stimulation may inhibit the beneficial effects of levodopa on akinesia and gait.</ArticleTitle><Pagination><MedlinePgn>1389-97</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.26545</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Gait and akinesia deterioration in PD patients during the immediate postoperative period of DBS has been directly related to stimulation in the subthalamic region. The underlying mechanisms remain poorly understood. The aim of the present study was to clinically and anatomically describe this side effect.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">PD patients presenting with a worsening of gait and/or akinesia following STN-DBS, that was reversible on stimulation arrest were included. The evaluation included (1) a Stand Walk Sit Test during a monopolar survey of each electrode in the on-drug condition; (2) a 5-condition test with the following conditions: off-drug/off-DBS, off-drug/on-best-compromise-DBS, on-drug/off-DBS, on-drug/on-best-compromise-DBS, and on-drug/on-worsening-DBS, which utilized the contact inducing the most prominent gait deterioration. The following scales were performed: UPDRSIII subscores, Stand Walk Sit Test, and dyskinesia and freezing of gait scales. Localization of contacts was performed using a coregistration method.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Twelve of 17 patients underwent the complete evaluation. Stimulation of the most proximal contacts significantly slowed down the Stand Walk Sit Test. The on-drug/on-worsening-DBS condition compared with the on-drug/off-DBS condition worsened akinesia (P = 0.02), Stand Walk Sit Test (P = 0.001), freezing of gait (P = 0.02), and improved dyskinesias (P = 0.003). Compared with the off-drug/off-DBS condition, the on-drug/on-worsening-DBS condition improved rigidity (P = 0.007) and tremor (P = 0.007). Worsening contact sites were predominantly dorsal and anterior to the STN in the anterior zona incerta and Forel fields H2.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">A paradoxical deterioration of gait and akinesia is a rare side effect following STN-DBS. We propose that this may be related to misplaced contacts, and we discuss the pathophysiology and strategies to identify and manage this complication. © 2016 International Parkinson and Movement Disorder Society.</AbstractText><CopyrightInformation>© 2016 International Parkinson and Movement Disorder Society.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fleury</LastName><ForeName>Vanessa</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Neurology, Geneva University Hospital, Geneva, Switzerland. Vanessa.FleuryNissen@hcuge.ch.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France. Vanessa.FleuryNissen@hcuge.ch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pollak</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Neurology, Geneva University Hospital, Geneva, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gere</LastName><ForeName>Julien</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Savoie Hospital, Chambery, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tommasi</LastName><ForeName>Giorgio</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, University Hospital of Verona, Verona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Romito</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Combescure</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Health and Community Medicine, Geneva University Hospital, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bardinet</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Sorbonne Université, UPMC Univ Paris, Inserm U975, CNRS UMR 7225, Centre de Neuroimagerie de Recherche, Institut du Cerveau et de la Moelle Épinière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabardes</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Momjian</LastName><ForeName>Shahan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurosurgery, Geneva University Hospital, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krainik</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>US 017, INSERM, UMS 3552, CNRS, Grenoble University Hospital, Neuroradiology and MRI, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burkhard</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Neurology, Geneva University Hospital, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yelnik</LastName><ForeName>Jérôme</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Sorbonne Université, UPMC Univ Paris, Inserm U975, CNRS UMR 7225, Centre de Neuroimagerie de Recherche, Institut du Cerveau et de la Moelle Épinière, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krack</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Movement Disorder Unit, Department of Psychiatry and Neurology, Grenoble University Hospital, Grenoble, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>INSERM U836, University Grenoble Alpes, Grenoble Neuroscience Institute, Grenoble, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>06</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>12</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26887333</ArticleId><ArticleId IdType="doi">10.1002/mds.26545</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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