Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions.
Identifieur interne : 001876 ( PubMed/Corpus ); précédent : 001875; suivant : 001877Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions.
Auteurs : M B Delisle ; P. Gorce ; E. Hirsch ; J J Hauw ; A. Rascol ; H. BouissouSource :
- Acta neuropathologica [ 0001-6322 ] ; 1987.
English descriptors
- KwdEn :
- Brain (pathology), Brain (ultrastructure), Cytoplasmic Granules (ultrastructure), Dementia (complications), Dementia (pathology), Humans, Male, Microscopy, Electron, Middle Aged, Motor Neurons, Neuromuscular Diseases (complications), Neuromuscular Diseases (pathology), Parkinson Disease (complications), Parkinson Disease (pathology), Spinal Cord (pathology), Spinal Cord (ultrastructure).
- MESH :
- complications : Dementia, Neuromuscular Diseases, Parkinson Disease.
- pathology : Brain, Dementia, Neuromuscular Diseases, Parkinson Disease, Spinal Cord.
- ultrastructure : Brain, Cytoplasmic Granules, Spinal Cord.
- Humans, Male, Microscopy, Electron, Middle Aged, Motor Neurons.
Abstract
The clinicopathological findings in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.
PubMed: 3434209
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pubmed:3434209Le document en format XML
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Rascol</name></author><author><name sortKey="Bouissou, H" sort="Bouissou, H" uniqKey="Bouissou H" first="H" last="Bouissou">H. Bouissou</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1987">1987</date><idno type="RBID">pubmed:3434209</idno><idno type="pmid">3434209</idno><idno type="wicri:Area/PubMed/Corpus">001876</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001876</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions.</title><author><name sortKey="Delisle, M B" sort="Delisle, M B" uniqKey="Delisle M" first="M B" last="Delisle">M B Delisle</name><affiliation><nlm:affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gorce, P" sort="Gorce, P" uniqKey="Gorce P" first="P" last="Gorce">P. Gorce</name></author><author><name sortKey="Hirsch, E" sort="Hirsch, E" uniqKey="Hirsch E" first="E" last="Hirsch">E. Hirsch</name></author><author><name sortKey="Hauw, J J" sort="Hauw, J J" uniqKey="Hauw J" first="J J" last="Hauw">J J Hauw</name></author><author><name sortKey="Rascol, A" sort="Rascol, A" uniqKey="Rascol A" first="A" last="Rascol">A. Rascol</name></author><author><name sortKey="Bouissou, H" sort="Bouissou, H" uniqKey="Bouissou H" first="H" last="Bouissou">H. Bouissou</name></author></analytic><series><title level="j">Acta neuropathologica</title><idno type="ISSN">0001-6322</idno><imprint><date when="1987" type="published">1987</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (pathology)</term><term>Brain (ultrastructure)</term><term>Cytoplasmic Granules (ultrastructure)</term><term>Dementia (complications)</term><term>Dementia (pathology)</term><term>Humans</term><term>Male</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Motor Neurons</term><term>Neuromuscular Diseases (complications)</term><term>Neuromuscular Diseases (pathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Spinal Cord (pathology)</term><term>Spinal Cord (ultrastructure)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dementia</term><term>Neuromuscular Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Dementia</term><term>Neuromuscular Diseases</term><term>Parkinson Disease</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Brain</term><term>Cytoplasmic Granules</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term><term>Microscopy, Electron</term><term>Middle Aged</term><term>Motor Neurons</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinicopathological findings in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3434209</PMID><DateCreated><Year>1988</Year><Month>03</Month><Day>04</Day></DateCreated><DateCompleted><Year>1988</Year><Month>03</Month><Day>04</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0001-6322</ISSN><JournalIssue CitedMedium="Print"><Volume>75</Volume><Issue>1</Issue><PubDate><Year>1987</Year></PubDate></JournalIssue><Title>Acta neuropathologica</Title><ISOAbbreviation>Acta Neuropathol.</ISOAbbreviation></Journal><ArticleTitle>Motor neuron disease, parkinsonism and dementia. Report of a case with diffuse Lewy body-like intracytoplasmic inclusions.</ArticleTitle><Pagination><MedlinePgn>104-8</MedlinePgn></Pagination><Abstract><AbstractText>The clinicopathological findings in a 49-year-old man who presented multisystemic neurological degenerative disease are reported. The patient presented, at the age of 36, distal upper limb amyotrophy and 8 years later pyramidal signs with fasciculations. In his last year of life, he suffered extrapyramidal hypertonus and mental deterioration. Neuropathological examination showed anterior spinal root and cerebral atrophy. Myelin pallor was mild and predominated on posterior cords. Anterior horn neuronal loss was noted in the spinal cord as well as Alzheimer-type changes in the brain. Inclusion bodies consistent with Lewy bodies were diffusely apparent. The peculiar clinical progression in this case and the extension of neuropathological lesions with inclusion bodies mainly in the substantia nigra and cerebral cortex are an interesting subject of discussion.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Delisle</LastName><ForeName>M B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Laboratoire d'Anatomie Pathologique, CHU Rangueil, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gorce</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Hirsch</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Hauw</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Bouissou</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Acta Neuropathol</MedlineTA><NlmUniqueID>0412041</NlmUniqueID><ISSNLinking>0001-6322</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003594" MajorTopicYN="N">Cytoplasmic Granules</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003704" MajorTopicYN="N">Dementia</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008854" MajorTopicYN="N">Microscopy, Electron</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009046" MajorTopicYN="Y">Motor Neurons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009468" MajorTopicYN="N">Neuromuscular Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013116" MajorTopicYN="N">Spinal Cord</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1987</Year><Month>1</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1987</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1987</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">3434209</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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