Does levodopa aggravate Parkinson's disease?
Identifieur interne : 001861 ( PubMed/Corpus ); précédent : 001860; suivant : 001862Does levodopa aggravate Parkinson's disease?
Auteurs : J. Blin ; A M Bonnet ; Y. AgidSource :
- Neurology [ 0028-3878 ] ; 1988.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Levodopa.
- chemical , therapeutic use : Levodopa.
- drug therapy : Parkinson Disease.
- etiology : Parkinson Disease.
- Female, Humans, Male, Middle Aged.
Abstract
We studied the possible deleterious effect of levodopa therapy on 185 patients with Parkinson's disease and concluded that the time when levodopa is introduced, the daily dose, and the duration of treatment do not aggravate Parkinson's disease. We also studied 72 parkinsonian patients with levodopa-induced abnormal involuntary movements to see whether early initiation of levodopa therapy affected the time of onset of abnormal involuntary movements. The results suggested that it did not, and that levodopa was started early in these patients because of the severity of their motor disability.
PubMed: 3412589
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pubmed:3412589Le document en format XML
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Agid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1988">1988</date><idno type="RBID">pubmed:3412589</idno><idno type="pmid">3412589</idno><idno type="wicri:Area/PubMed/Corpus">001861</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001861</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Does levodopa aggravate Parkinson's disease?</title><author><name sortKey="Blin, J" sort="Blin, J" uniqKey="Blin J" first="J" last="Blin">J. Blin</name><affiliation><nlm:affiliation>Laboratoire de Médecine Expérimentale, INSERM U 289, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnet, A M" sort="Bonnet, A M" uniqKey="Bonnet A" first="A M" last="Bonnet">A M Bonnet</name></author><author><name sortKey="Agid, Y" sort="Agid, Y" uniqKey="Agid Y" first="Y" last="Agid">Y. Agid</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Female</term><term>Humans</term><term>Levodopa (adverse effects)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (etiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the possible deleterious effect of levodopa therapy on 185 patients with Parkinson's disease and concluded that the time when levodopa is introduced, the daily dose, and the duration of treatment do not aggravate Parkinson's disease. We also studied 72 parkinsonian patients with levodopa-induced abnormal involuntary movements to see whether early initiation of levodopa therapy affected the time of onset of abnormal involuntary movements. The results suggested that it did not, and that levodopa was started early in these patients because of the severity of their motor disability.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">3412589</PMID><DateCreated><Year>1988</Year><Month>10</Month><Day>05</Day></DateCreated><DateCompleted><Year>1988</Year><Month>10</Month><Day>05</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN><JournalIssue CitedMedium="Print"><Volume>38</Volume><Issue>9</Issue><PubDate><Year>1988</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Does levodopa aggravate Parkinson's disease?</ArticleTitle><Pagination><MedlinePgn>1410-6</MedlinePgn></Pagination><Abstract><AbstractText>We studied the possible deleterious effect of levodopa therapy on 185 patients with Parkinson's disease and concluded that the time when levodopa is introduced, the daily dose, and the duration of treatment do not aggravate Parkinson's disease. We also studied 72 parkinsonian patients with levodopa-induced abnormal involuntary movements to see whether early initiation of levodopa therapy affected the time of onset of abnormal involuntary movements. 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