ParkinsonFranceV1, PubMed, Corpus, bibRecord, 001803

Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.

Identifieur interne : 001803 ( PubMed/Corpus ); précédent : 001802; suivant : 001804

Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.

Auteurs : F. Durif ; E. Jeanneau ; F. Serre-Debeauvais ; D. Deffond ; A. Eschalier ; M. Tournilhac

Source :

European journal of clinical pharmacology [ 0031-6970 ] ; 1991.

RBID : pubmed:1761081

English descriptors

KwdEn :
- Administration, Sublingual, Aged, Apomorphine (administration & dosage), Apomorphine (blood), Apomorphine (therapeutic use), Female, Humans, Male, Middle Aged, Parkinson Disease (drug therapy).
MESH :
- chemical , administration & dosage : Apomorphine.
- chemical , blood : Apomorphine.
- chemical , therapeutic use : Apomorphine.
- drug therapy : Parkinson Disease.
- Administration, Sublingual, Aged, Female, Humans, Male, Middle Aged.

Abstract

Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.

DOI: 10.1007/BF00626377
PubMed: 1761081

Links to Exploration step

pubmed:1761081

Le document en format XML

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<author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name>
<affiliation><nlm:affiliation>Clinique Neurologique, CHU Clermont Ferrand, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jeanneau, E" sort="Jeanneau, E" uniqKey="Jeanneau E" first="E" last="Jeanneau">E. Jeanneau</name>
</author>
<author><name sortKey="Serre Debeauvais, F" sort="Serre Debeauvais, F" uniqKey="Serre Debeauvais F" first="F" last="Serre-Debeauvais">F. Serre-Debeauvais</name>
</author>
<author><name sortKey="Deffond, D" sort="Deffond, D" uniqKey="Deffond D" first="D" last="Deffond">D. Deffond</name>
</author>
<author><name sortKey="Eschalier, A" sort="Eschalier, A" uniqKey="Eschalier A" first="A" last="Eschalier">A. Eschalier</name>
</author>
<author><name sortKey="Tournilhac, M" sort="Tournilhac, M" uniqKey="Tournilhac M" first="M" last="Tournilhac">M. Tournilhac</name>
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<affiliation><nlm:affiliation>Clinique Neurologique, CHU Clermont Ferrand, France.</nlm:affiliation>
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<author><name sortKey="Jeanneau, E" sort="Jeanneau, E" uniqKey="Jeanneau E" first="E" last="Jeanneau">E. Jeanneau</name>
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<author><name sortKey="Serre Debeauvais, F" sort="Serre Debeauvais, F" uniqKey="Serre Debeauvais F" first="F" last="Serre-Debeauvais">F. Serre-Debeauvais</name>
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<author><name sortKey="Deffond, D" sort="Deffond, D" uniqKey="Deffond D" first="D" last="Deffond">D. Deffond</name>
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<author><name sortKey="Eschalier, A" sort="Eschalier, A" uniqKey="Eschalier A" first="A" last="Eschalier">A. Eschalier</name>
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<author><name sortKey="Tournilhac, M" sort="Tournilhac, M" uniqKey="Tournilhac M" first="M" last="Tournilhac">M. Tournilhac</name>
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<series><title level="j">European journal of clinical pharmacology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Sublingual</term>
<term>Aged</term>
<term>Apomorphine (administration & dosage)</term>
<term>Apomorphine (blood)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Parkinson Disease (drug therapy)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Apomorphine</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Sublingual</term>
<term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.</div>
</front>
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<Month>02</Month>
<Day>12</Day>
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<DateCompleted><Year>1992</Year>
<Month>02</Month>
<Day>12</Day>
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<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0031-6970</ISSN>
<JournalIssue CitedMedium="Print"><Volume>41</Volume>
<Issue>5</Issue>
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<Title>European journal of clinical pharmacology</Title>
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<ArticleTitle>Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.</ArticleTitle>
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<Abstract><AbstractText>Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.</AbstractText>
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<Author ValidYN="Y"><LastName>Serre-Debeauvais</LastName>
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<Author ValidYN="Y"><LastName>Deffond</LastName>
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<Author ValidYN="Y"><LastName>Eschalier</LastName>
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<QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
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Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.

Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki