Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.
Identifieur interne : 001803 ( PubMed/Corpus ); précédent : 001802; suivant : 001804Relation between plasma concentration and clinical efficacy after sublingual single dose apomorphine in Parkinson's disease.
Auteurs : F. Durif ; E. Jeanneau ; F. Serre-Debeauvais ; D. Deffond ; A. Eschalier ; M. TournilhacSource :
- European journal of clinical pharmacology [ 0031-6970 ] ; 1991.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Apomorphine.
- chemical , blood : Apomorphine.
- chemical , therapeutic use : Apomorphine.
- drug therapy : Parkinson Disease.
- Administration, Sublingual, Aged, Female, Humans, Male, Middle Aged.
Abstract
Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.
DOI: 10.1007/BF00626377
PubMed: 1761081
Links to Exploration step
pubmed:1761081Le document en format XML
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<author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name>
<affiliation><nlm:affiliation>Clinique Neurologique, CHU Clermont Ferrand, France.</nlm:affiliation>
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<author><name sortKey="Jeanneau, E" sort="Jeanneau, E" uniqKey="Jeanneau E" first="E" last="Jeanneau">E. Jeanneau</name>
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<author><name sortKey="Serre Debeauvais, F" sort="Serre Debeauvais, F" uniqKey="Serre Debeauvais F" first="F" last="Serre-Debeauvais">F. Serre-Debeauvais</name>
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<author><name sortKey="Deffond, D" sort="Deffond, D" uniqKey="Deffond D" first="D" last="Deffond">D. Deffond</name>
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<author><name sortKey="Eschalier, A" sort="Eschalier, A" uniqKey="Eschalier A" first="A" last="Eschalier">A. Eschalier</name>
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<author><name sortKey="Tournilhac, M" sort="Tournilhac, M" uniqKey="Tournilhac M" first="M" last="Tournilhac">M. Tournilhac</name>
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<author><name sortKey="Serre Debeauvais, F" sort="Serre Debeauvais, F" uniqKey="Serre Debeauvais F" first="F" last="Serre-Debeauvais">F. Serre-Debeauvais</name>
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<term>Apomorphine (administration & dosage)</term>
<term>Apomorphine (blood)</term>
<term>Apomorphine (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<term>Parkinson Disease (drug therapy)</term>
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<keywords scheme="MESH" xml:lang="en"><term>Administration, Sublingual</term>
<term>Aged</term>
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<front><div type="abstract" xml:lang="en">Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.</div>
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<Abstract><AbstractText>Five patients with Parkinson's disease were given a single sublingual dose of apomorphine in 3 mg tablets (2 patients received 18 mg and 3 patients took 39 mg). The therapeutic effect appeared within 33.0 min and lasted 137 min. There was a significant correlation between peak concentration, area under the curve, dose (mg/kg) and the duration of the therapeutic effect.</AbstractText>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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