Serotonergic sprouting in primate MTP-induced hemiparkinsonism.
Identifieur interne : 001739 ( PubMed/Corpus ); précédent : 001738; suivant : 001740Serotonergic sprouting in primate MTP-induced hemiparkinsonism.
Auteurs : P. Gaspar ; A. Febvret ; J. ColomboSource :
- Experimental brain research [ 0014-4819 ] ; 1993.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Animals, Brain (enzymology), Brain (pathology), Brain Chemistry (physiology), Cebus, Dopamine (physiology), Dopamine beta-Hydroxylase (immunology), Female, Immunohistochemistry, Male, Neural Pathways (pathology), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (enzymology), Parkinson Disease, Secondary (pathology), Serotonin (immunology), Serotonin (physiology), Tyrosine 3-Monooxygenase (immunology).
- MESH :
- chemical , immunology : Dopamine beta-Hydroxylase, Serotonin, Tyrosine 3-Monooxygenase.
- chemical , physiology : Dopamine, Serotonin.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- chemically induced : Parkinson Disease, Secondary.
- enzymology : Brain, Parkinson Disease, Secondary.
- pathology : Brain, Neural Pathways, Parkinson Disease, Secondary.
- physiology : Brain Chemistry.
- Animals, Cebus, Female, Immunohistochemistry, Male.
Abstract
Immunocytochemistry to serotonin, dopamine beta hydroxylase (DBH), and tyrosine hydroxylase (TH) was studied in the brains of 2 cebus monkeys that had developed permanent hemiparkinsonism after intracarotid injection of 1.2 mg N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and were sacrificed after 10-12 months. A pronounced depletion of TH-immunoreactive neurons was found in the substantia nigra, caudate nucleus, and putamen, ipsilaterally to the injected side. In these dopamine-denervated structures, the number of serotonergic fibers was increased in the ipsilateral compared with the contralateral side, or with an untreated control monkey. Serotonergic neurons in the brainstem appeared to be unaffected. Topography and number of DBH-positive fibers in the control and the MPTP-injected sides were comparable.
PubMed: 7902292
Links to Exploration step
pubmed:7902292Le document en format XML
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<author><name sortKey="Gaspar, P" sort="Gaspar, P" uniqKey="Gaspar P" first="P" last="Gaspar">P. Gaspar</name>
<affiliation><nlm:affiliation>INSERM U106, Hopital Salpêtrère, Paris, France.</nlm:affiliation>
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<author><name sortKey="Febvret, A" sort="Febvret, A" uniqKey="Febvret A" first="A" last="Febvret">A. Febvret</name>
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<author><name sortKey="Colombo, J" sort="Colombo, J" uniqKey="Colombo J" first="J" last="Colombo">J. Colombo</name>
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<author><name sortKey="Gaspar, P" sort="Gaspar, P" uniqKey="Gaspar P" first="P" last="Gaspar">P. Gaspar</name>
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<author><name sortKey="Febvret, A" sort="Febvret, A" uniqKey="Febvret A" first="A" last="Febvret">A. Febvret</name>
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<author><name sortKey="Colombo, J" sort="Colombo, J" uniqKey="Colombo J" first="J" last="Colombo">J. Colombo</name>
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<term>Animals</term>
<term>Brain (enzymology)</term>
<term>Brain (pathology)</term>
<term>Brain Chemistry (physiology)</term>
<term>Cebus</term>
<term>Dopamine (physiology)</term>
<term>Dopamine beta-Hydroxylase (immunology)</term>
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<term>Immunohistochemistry</term>
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<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (enzymology)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Serotonin (immunology)</term>
<term>Serotonin (physiology)</term>
<term>Tyrosine 3-Monooxygenase (immunology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Dopamine beta-Hydroxylase</term>
<term>Serotonin</term>
<term>Tyrosine 3-Monooxygenase</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term>
<term>Serotonin</term>
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<front><div type="abstract" xml:lang="en">Immunocytochemistry to serotonin, dopamine beta hydroxylase (DBH), and tyrosine hydroxylase (TH) was studied in the brains of 2 cebus monkeys that had developed permanent hemiparkinsonism after intracarotid injection of 1.2 mg N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and were sacrificed after 10-12 months. A pronounced depletion of TH-immunoreactive neurons was found in the substantia nigra, caudate nucleus, and putamen, ipsilaterally to the injected side. In these dopamine-denervated structures, the number of serotonergic fibers was increased in the ipsilateral compared with the contralateral side, or with an untreated control monkey. Serotonergic neurons in the brainstem appeared to be unaffected. Topography and number of DBH-positive fibers in the control and the MPTP-injected sides were comparable.</div>
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<ArticleTitle>Serotonergic sprouting in primate MTP-induced hemiparkinsonism.</ArticleTitle>
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<Abstract><AbstractText>Immunocytochemistry to serotonin, dopamine beta hydroxylase (DBH), and tyrosine hydroxylase (TH) was studied in the brains of 2 cebus monkeys that had developed permanent hemiparkinsonism after intracarotid injection of 1.2 mg N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and were sacrificed after 10-12 months. A pronounced depletion of TH-immunoreactive neurons was found in the substantia nigra, caudate nucleus, and putamen, ipsilaterally to the injected side. In these dopamine-denervated structures, the number of serotonergic fibers was increased in the ipsilateral compared with the contralateral side, or with an untreated control monkey. Serotonergic neurons in the brainstem appeared to be unaffected. Topography and number of DBH-positive fibers in the control and the MPTP-injected sides were comparable.</AbstractText>
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