Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease.
Identifieur interne : 001723 ( PubMed/Corpus ); précédent : 001722; suivant : 001724Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease.
Auteurs : D. Caparros-Lefebvre ; S. Blond ; P. Vermersch ; N. Pécheux ; J D Guieu ; H. PetitSource :
- Journal of neurology, neurosurgery, and psychiatry [ 0022-3050 ] ; 1993.
English descriptors
- KwdEn :
- Aged, Combined Modality Therapy, Dose-Response Relationship, Drug, Dyskinesia, Drug-Induced (physiopathology), Dyskinesia, Drug-Induced (therapy), Electric Stimulation Therapy (instrumentation), Electromyography (drug effects), Female, Follow-Up Studies, Humans, Levodopa (administration & dosage), Levodopa (adverse effects), Male, Middle Aged, Neurologic Examination (drug effects), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Prostheses and Implants, Thalamic Nuclei (physiopathology), Tremor (physiopathology), Tremor (therapy).
- MESH :
- chemical , administration & dosage : Levodopa.
- chemical , adverse effects : Levodopa.
- drug effects : Electromyography, Neurologic Examination.
- instrumentation : Electric Stimulation Therapy.
- physiopathology : Dyskinesia, Drug-Induced, Parkinson Disease, Thalamic Nuclei, Tremor.
- therapy : Dyskinesia, Drug-Induced, Parkinson Disease, Tremor.
- Aged, Combined Modality Therapy, Dose-Response Relationship, Drug, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prostheses and Implants.
Abstract
Chronic thalamic stimulation was performed in 10 Parkinsonian patients with disabling tremor and poor response to drug therapy. During the stereotactic procedure, an electrode was introduced in the ventralis intermediate nucleus of the thalamus. Test stimulation was performed during the intra-operative procedure and a few days after surgery using an external stimulator. When tremor was obviously reduced by thalamic stimulation, an internal stimulator was implanted under the clavicle. Tremor was initially suppressed in all cases and reappeared whenever stimulation was stopped. Patients were followed for 22 to 34 months. Tremor was controlled in eight cases but reappeared after three months in two cases. Levodopa induced dyskinesias were observed before electrode implantation in 5 cases. They consisted of peak-dose choreic or ballistic dyskinesias in 4 cases and biphasic dystonic dyskinesias in 3 cases. Peak-dose dyskinesias were greatly improved or suppressed in all cases. Biphasic dyskinesias were improved in 2 cases. Thalamic stimulation was well tolerated. Mild dystonic hand posture related to the deep brain stimulation was observed in one case. No neuropsychological side-effects were noted. Thalamic stimulation could prove to be an adequate treatment for resistant tremor and levodopa induced dyskinesias.
PubMed: 8459243
Links to Exploration step
pubmed:8459243Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease.</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D" last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation><nlm:affiliation>Department of Neurology, CHRU Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S" last="Blond">S. Blond</name></author><author><name sortKey="Vermersch, P" sort="Vermersch, P" uniqKey="Vermersch P" first="P" last="Vermersch">P. Vermersch</name></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N" last="Pécheux">N. Pécheux</name></author><author><name sortKey="Guieu, J D" sort="Guieu, J D" uniqKey="Guieu J" first="J D" last="Guieu">J D Guieu</name></author><author><name sortKey="Petit, H" sort="Petit, H" uniqKey="Petit H" first="H" last="Petit">H. Petit</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1993">1993</date><idno type="RBID">pubmed:8459243</idno><idno type="pmid">8459243</idno><idno type="wicri:Area/PubMed/Corpus">001723</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001723</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease.</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D" last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation><nlm:affiliation>Department of Neurology, CHRU Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blond, S" sort="Blond, S" uniqKey="Blond S" first="S" last="Blond">S. Blond</name></author><author><name sortKey="Vermersch, P" sort="Vermersch, P" uniqKey="Vermersch P" first="P" last="Vermersch">P. Vermersch</name></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N" last="Pécheux">N. Pécheux</name></author><author><name sortKey="Guieu, J D" sort="Guieu, J D" uniqKey="Guieu J" first="J D" last="Guieu">J D Guieu</name></author><author><name sortKey="Petit, H" sort="Petit, H" uniqKey="Petit H" first="H" last="Petit">H. Petit</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="1993" type="published">1993</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Dose-Response Relationship, Drug</term><term>Dyskinesia, Drug-Induced (physiopathology)</term><term>Dyskinesia, Drug-Induced (therapy)</term><term>Electric Stimulation Therapy (instrumentation)</term><term>Electromyography (drug effects)</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination (drug effects)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Prostheses and Implants</term><term>Thalamic Nuclei (physiopathology)</term><term>Tremor (physiopathology)</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Electromyography</term><term>Neurologic Examination</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Thalamic Nuclei</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Combined Modality Therapy</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prostheses and Implants</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic thalamic stimulation was performed in 10 Parkinsonian patients with disabling tremor and poor response to drug therapy. During the stereotactic procedure, an electrode was introduced in the ventralis intermediate nucleus of the thalamus. Test stimulation was performed during the intra-operative procedure and a few days after surgery using an external stimulator. When tremor was obviously reduced by thalamic stimulation, an internal stimulator was implanted under the clavicle. Tremor was initially suppressed in all cases and reappeared whenever stimulation was stopped. Patients were followed for 22 to 34 months. Tremor was controlled in eight cases but reappeared after three months in two cases. Levodopa induced dyskinesias were observed before electrode implantation in 5 cases. They consisted of peak-dose choreic or ballistic dyskinesias in 4 cases and biphasic dystonic dyskinesias in 3 cases. Peak-dose dyskinesias were greatly improved or suppressed in all cases. Biphasic dyskinesias were improved in 2 cases. Thalamic stimulation was well tolerated. Mild dystonic hand posture related to the deep brain stimulation was observed in one case. No neuropsychological side-effects were noted. Thalamic stimulation could prove to be an adequate treatment for resistant tremor and levodopa induced dyskinesias.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8459243</PMID><DateCreated><Year>1993</Year><Month>04</Month><Day>29</Day></DateCreated><DateCompleted><Year>1993</Year><Month>04</Month><Day>29</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3050</ISSN><JournalIssue CitedMedium="Print"><Volume>56</Volume><Issue>3</Issue><PubDate><Year>1993</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>268-73</MedlinePgn></Pagination><Abstract><AbstractText>Chronic thalamic stimulation was performed in 10 Parkinsonian patients with disabling tremor and poor response to drug therapy. During the stereotactic procedure, an electrode was introduced in the ventralis intermediate nucleus of the thalamus. Test stimulation was performed during the intra-operative procedure and a few days after surgery using an external stimulator. When tremor was obviously reduced by thalamic stimulation, an internal stimulator was implanted under the clavicle. Tremor was initially suppressed in all cases and reappeared whenever stimulation was stopped. Patients were followed for 22 to 34 months. Tremor was controlled in eight cases but reappeared after three months in two cases. Levodopa induced dyskinesias were observed before electrode implantation in 5 cases. They consisted of peak-dose choreic or ballistic dyskinesias in 4 cases and biphasic dystonic dyskinesias in 3 cases. Peak-dose dyskinesias were greatly improved or suppressed in all cases. Biphasic dyskinesias were improved in 2 cases. Thalamic stimulation was well tolerated. Mild dystonic hand posture related to the deep brain stimulation was observed in one case. No neuropsychological side-effects were noted. Thalamic stimulation could prove to be an adequate treatment for resistant tremor and levodopa induced dyskinesias.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Caparros-Lefebvre</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Neurology, CHRU Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blond</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Vermersch</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Pécheux</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Guieu</LastName><ForeName>J D</ForeName><Initials>JD</Initials></Author><Author ValidYN="Y"><LastName>Petit</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Br Med J. 1971 Jan 2;1(5739):7-13</RefSource><PMID Version="1">4923653</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):831-9</RefSource><PMID Version="1">6381653</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 1979 Mar;50(3):290-7</RefSource><PMID Version="1">370349</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1980 Jun 7;1(8180):1221-2</RefSource><PMID Version="1">6104038</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 1986 Jan 2;63(1):61-5</RefSource><PMID Version="1">3485267</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Annu Rev Neurosci. 1986;9:357-81</RefSource><PMID Version="1">3085570</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mt Sinai J Med. 1988 Jan;55(1):50-7</RefSource><PMID Version="1">3279304</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Appl Neurophysiol. 1987;50(1-6):344-6</RefSource><PMID Version="1">3329873</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1988 Oct;111 ( Pt 5):1211-33</RefSource><PMID Version="1">3179691</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rev Neurol (Paris). 1989;145(4):320-3</RefSource><PMID Version="1">2660224</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Trends Neurosci. 1989 Oct;12(10):366-75</RefSource><PMID Version="1">2479133</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1990;5(1):3-7</RefSource><PMID Version="1">2296255</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1990;5(2):100-8</RefSource><PMID Version="1">1970120</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1990 May;53(5):427-30</RefSource><PMID Version="1">2191085</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 1991 Feb 16;337(8738):403-6</RefSource><PMID Version="1">1671433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Acta Neurochir Suppl (Wien). 1991;52:109-11</RefSource><PMID Version="1">1792949</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Rev Neurol (Paris). 1992;148(2):117-22</RefSource><PMID Version="1">1604121</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prog Brain Res. 1979;51:237-83</RefSource><PMID Version="1">399353</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1983 Dec;106 ( Pt 4):1001-18</RefSource><PMID Version="1">6360305</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Appl Neurophysiol. 1983;46(1-4):107-11</RefSource><PMID Version="1">6608315</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Appl Neurophysiol. 1983;46(1-4):68-83</RefSource><PMID Version="1">6367656</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clin Neurosurg. 1977;24:367-90</RefSource><PMID Version="1">303972</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="N">Electric Stimulation Therapy</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004576" MajorTopicYN="N">Electromyography</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009460" MajorTopicYN="N">Neurologic Examination</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019736" MajorTopicYN="Y">Prostheses and Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013787" MajorTopicYN="N">Thalamic Nuclei</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014202" MajorTopicYN="N">Tremor</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC1014859</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1993</Year><Month>3</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1993</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1993</Year><Month>3</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8459243</ArticleId><ArticleId IdType="pmc">PMC1014859</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001723 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001723 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:8459243
|texte= Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:8459243" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |