Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon.
Identifieur interne : 001676 ( PubMed/Corpus ); précédent : 001675; suivant : 001677Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon.
Auteurs : M. Peschanski ; G. Defer ; J P N'Guyen ; F. Ricolfi ; J C Monfort ; P. Remy ; C. Geny ; Y. Samson ; P. Hantraye ; R. JenySource :
- Brain : a journal of neurology [ 0006-8950 ] ; 1994.
English descriptors
- KwdEn :
- Adult, Aged, Brain Tissue Transplantation, Corpus Striatum (surgery), Female, Fetal Tissue Transplantation, Humans, Levodopa (therapeutic use), Male, Mesencephalon (transplantation), Middle Aged, Motor Activity, Parkinson Disease (diagnostic imaging), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Tomography, Emission-Computed.
- MESH :
- chemical , therapeutic use : Levodopa.
- diagnostic imaging : Parkinson Disease.
- drug therapy : Parkinson Disease.
- physiopathology : Parkinson Disease.
- surgery : Corpus Striatum, Parkinson Disease.
- transplantation : Mesencephalon.
- Adult, Aged, Brain Tissue Transplantation, Female, Fetal Tissue Transplantation, Humans, Male, Middle Aged, Motor Activity, Tomography, Emission-Computed.
Abstract
Several recent reports have suggested that foetal ventral mesencephalic transplants could alleviate motor symptoms in patients with Parkinson's disease. Expectations of future success must be clarified by precise analysis of the extent and limitation of recovery associated with an assessment of function of the graft using [18F]fluorodopa (18F-dopa) PET. Two patients with idiopathic Parkinson's disease, severely impaired despite optimal medication, have been followed 10 and 17 months after stereotaxic unilateral intrastriatal transplantation of neural cells dissociated from human foetal ventral mesencephalon. Analysis of the clinical evolution complied with the protocol established in the 'Core Assessment Program for Intracerebral Transplantation'. Both patients have benefited from the transplantation in their daily activities and in motor timed tests, although they still exhibit parkinsonian symptoms and require L-dopa therapy. This is associated with a gradual increase in 18F-dopa uptake at the site of grafting. There are two major clinical changes: (i) a bilateral motor improvement for the speed of movements (the quality of movements improved almost exclusively on the side contralateral to the graft); (ii) a change in the outcome of the L-dopa treatment as exemplified by a postoperative transient period of heavy dyskinesias and subsequent additive actions of the two treatments. These results confirm that neural transplantation may be useful for patients with Parkinson's disease. The improvement recorded on the side ipsilateral to the graft does not match that observed on the contralateral side and it is proposed that bilateral transplantation may be necessary. The existence of a transient postoperative period of heavy dyskinesias suggests that the patients may benefit from a controlled decrease of L-dopa intake after grafting.
PubMed: 8032859
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon.</title><author><name sortKey="Peschanski, M" sort="Peschanski, M" uniqKey="Peschanski M" first="M" last="Peschanski">M. Peschanski</name><affiliation><nlm:affiliation>INSERM CJF 91-02 Neuroplasticité et Greffes, Intracérébrales, Faculté de médecine, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. Defer</name></author><author><name sortKey="N Guyen, J P" sort="N Guyen, J P" uniqKey="N Guyen J" first="J P" last="N'Guyen">J P N'Guyen</name></author><author><name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F" last="Ricolfi">F. Ricolfi</name></author><author><name sortKey="Monfort, J C" sort="Monfort, J C" uniqKey="Monfort J" first="J C" last="Monfort">J C Monfort</name></author><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name></author><author><name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C" last="Geny">C. Geny</name></author><author><name sortKey="Samson, Y" sort="Samson, Y" uniqKey="Samson Y" first="Y" last="Samson">Y. Samson</name></author><author><name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P" last="Hantraye">P. Hantraye</name></author><author><name sortKey="Jeny, R" sort="Jeny, R" uniqKey="Jeny R" first="R" last="Jeny">R. Jeny</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:8032859</idno><idno type="pmid">8032859</idno><idno type="wicri:Area/PubMed/Corpus">001676</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001676</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon.</title><author><name sortKey="Peschanski, M" sort="Peschanski, M" uniqKey="Peschanski M" first="M" last="Peschanski">M. Peschanski</name><affiliation><nlm:affiliation>INSERM CJF 91-02 Neuroplasticité et Greffes, Intracérébrales, Faculté de médecine, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. Defer</name></author><author><name sortKey="N Guyen, J P" sort="N Guyen, J P" uniqKey="N Guyen J" first="J P" last="N'Guyen">J P N'Guyen</name></author><author><name sortKey="Ricolfi, F" sort="Ricolfi, F" uniqKey="Ricolfi F" first="F" last="Ricolfi">F. Ricolfi</name></author><author><name sortKey="Monfort, J C" sort="Monfort, J C" uniqKey="Monfort J" first="J C" last="Monfort">J C Monfort</name></author><author><name sortKey="Remy, P" sort="Remy, P" uniqKey="Remy P" first="P" last="Remy">P. Remy</name></author><author><name sortKey="Geny, C" sort="Geny, C" uniqKey="Geny C" first="C" last="Geny">C. Geny</name></author><author><name sortKey="Samson, Y" sort="Samson, Y" uniqKey="Samson Y" first="Y" last="Samson">Y. Samson</name></author><author><name sortKey="Hantraye, P" sort="Hantraye, P" uniqKey="Hantraye P" first="P" last="Hantraye">P. Hantraye</name></author><author><name sortKey="Jeny, R" sort="Jeny, R" uniqKey="Jeny R" first="R" last="Jeny">R. Jeny</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="ISSN">0006-8950</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Tissue Transplantation</term><term>Corpus Striatum (surgery)</term><term>Female</term><term>Fetal Tissue Transplantation</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Mesencephalon (transplantation)</term><term>Middle Aged</term><term>Motor Activity</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Mesencephalon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Tissue Transplantation</term><term>Female</term><term>Fetal Tissue Transplantation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Activity</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several recent reports have suggested that foetal ventral mesencephalic transplants could alleviate motor symptoms in patients with Parkinson's disease. Expectations of future success must be clarified by precise analysis of the extent and limitation of recovery associated with an assessment of function of the graft using [18F]fluorodopa (18F-dopa) PET. Two patients with idiopathic Parkinson's disease, severely impaired despite optimal medication, have been followed 10 and 17 months after stereotaxic unilateral intrastriatal transplantation of neural cells dissociated from human foetal ventral mesencephalon. Analysis of the clinical evolution complied with the protocol established in the 'Core Assessment Program for Intracerebral Transplantation'. Both patients have benefited from the transplantation in their daily activities and in motor timed tests, although they still exhibit parkinsonian symptoms and require L-dopa therapy. This is associated with a gradual increase in 18F-dopa uptake at the site of grafting. There are two major clinical changes: (i) a bilateral motor improvement for the speed of movements (the quality of movements improved almost exclusively on the side contralateral to the graft); (ii) a change in the outcome of the L-dopa treatment as exemplified by a postoperative transient period of heavy dyskinesias and subsequent additive actions of the two treatments. These results confirm that neural transplantation may be useful for patients with Parkinson's disease. The improvement recorded on the side ipsilateral to the graft does not match that observed on the contralateral side and it is proposed that bilateral transplantation may be necessary. The existence of a transient postoperative period of heavy dyskinesias suggests that the patients may benefit from a controlled decrease of L-dopa intake after grafting.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8032859</PMID><DateCreated><Year>1994</Year><Month>08</Month><Day>18</Day></DateCreated><DateCompleted><Year>1994</Year><Month>08</Month><Day>18</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0006-8950</ISSN><JournalIssue CitedMedium="Print"><Volume>117 ( Pt 3)</Volume><PubDate><Year>1994</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Brain : a journal of neurology</Title><ISOAbbreviation>Brain</ISOAbbreviation></Journal><ArticleTitle>Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of foetal ventral mesencephalon.</ArticleTitle><Pagination><MedlinePgn>487-99</MedlinePgn></Pagination><Abstract><AbstractText>Several recent reports have suggested that foetal ventral mesencephalic transplants could alleviate motor symptoms in patients with Parkinson's disease. Expectations of future success must be clarified by precise analysis of the extent and limitation of recovery associated with an assessment of function of the graft using [18F]fluorodopa (18F-dopa) PET. Two patients with idiopathic Parkinson's disease, severely impaired despite optimal medication, have been followed 10 and 17 months after stereotaxic unilateral intrastriatal transplantation of neural cells dissociated from human foetal ventral mesencephalon. Analysis of the clinical evolution complied with the protocol established in the 'Core Assessment Program for Intracerebral Transplantation'. Both patients have benefited from the transplantation in their daily activities and in motor timed tests, although they still exhibit parkinsonian symptoms and require L-dopa therapy. This is associated with a gradual increase in 18F-dopa uptake at the site of grafting. There are two major clinical changes: (i) a bilateral motor improvement for the speed of movements (the quality of movements improved almost exclusively on the side contralateral to the graft); (ii) a change in the outcome of the L-dopa treatment as exemplified by a postoperative transient period of heavy dyskinesias and subsequent additive actions of the two treatments. These results confirm that neural transplantation may be useful for patients with Parkinson's disease. The improvement recorded on the side ipsilateral to the graft does not match that observed on the contralateral side and it is proposed that bilateral transplantation may be necessary. The existence of a transient postoperative period of heavy dyskinesias suggests that the patients may benefit from a controlled decrease of L-dopa intake after grafting.</AbstractText></Abstract><AuthorList CompleteYN="N"><Author ValidYN="Y"><LastName>Peschanski</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INSERM CJF 91-02 Neuroplasticité et Greffes, Intracérébrales, Faculté de médecine, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Defer</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>N'Guyen</LastName><ForeName>J P</ForeName><Initials>JP</Initials></Author><Author ValidYN="Y"><LastName>Ricolfi</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Monfort</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Geny</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Samson</LastName><ForeName>Y</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Hantraye</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Jeny</LastName><ForeName>R</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Brain</MedlineTA><NlmUniqueID>0372537</NlmUniqueID><ISSNLinking>0006-8950</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016380" MajorTopicYN="Y">Brain Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016332" MajorTopicYN="Y">Fetal Tissue Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008636" MajorTopicYN="N">Mesencephalon</DescriptorName><QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="Y">Motor Activity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014055" MajorTopicYN="N">Tomography, Emission-Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>6</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>6</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8032859</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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