ParkinsonFranceV1, PubMed, Corpus, bibRecord, 001661

Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.

Identifieur interne : 001661 ( PubMed/Corpus ); précédent : 001660; suivant : 001662

Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.

Auteurs : R. Bordet ; F. Broly ; A. Destee ; C. Libersa

Source :

Clinical neuropharmacology [ 0362-5664 ] ; 1994.

RBID : pubmed:9316701

English descriptors

KwdEn :
- Aged, Cytochrome P-450 CYP2D6 (genetics), Female, Genotype, Humans, Male, Middle Aged, Mutation, Parkinson Disease (enzymology), Parkinson Disease (genetics), Polymerase Chain Reaction, Polymorphism, Genetic.
MESH :
- chemical , genetics : Cytochrome P-450 CYP2D6.
- enzymology : Parkinson Disease.
- genetics : Parkinson Disease.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Mutation, Polymerase Chain Reaction, Polymorphism, Genetic.

Abstract

We investigated genetic polymorphism of the cytochrome P450 CYP 2D6 gene in 105 caucasian patients with idiopathic Parkinson's disease (IPD) and 15 patients with diffuse Lewy body disease (DLBD). The mutations of the CYP 2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis. The rate of genotypically defined PM and the frequencies of the mutation D6-B were not significantly different in IPD and DLBD patients. This study fails to find a relationship between CYP 2D6 impairment and neuropathological lesions diffusion in IPD and DLBD. This study cannot exclude involvement of neuronal expression of CYP 2D6.

PubMed: 9316701

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pubmed:9316701

Le document en format XML

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<author><name sortKey="Bordet, R" sort="Bordet, R" uniqKey="Bordet R" first="R" last="Bordet">R. Bordet</name>
<affiliation><nlm:affiliation>Service de Neurologie A, CH et U de Lille, France.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Broly, F" sort="Broly, F" uniqKey="Broly F" first="F" last="Broly">F. Broly</name>
</author>
<author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destee">A. Destee</name>
</author>
<author><name sortKey="Libersa, C" sort="Libersa, C" uniqKey="Libersa C" first="C" last="Libersa">C. Libersa</name>
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<author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destee">A. Destee</name>
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<author><name sortKey="Libersa, C" sort="Libersa, C" uniqKey="Libersa C" first="C" last="Libersa">C. Libersa</name>
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<series><title level="j">Clinical neuropharmacology</title>
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<term>Female</term>
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<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Parkinson Disease (enzymology)</term>
<term>Parkinson Disease (genetics)</term>
<term>Polymerase Chain Reaction</term>
<term>Polymorphism, Genetic</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytochrome P-450 CYP2D6</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">We investigated genetic polymorphism of the cytochrome P450 CYP 2D6 gene in 105 caucasian patients with idiopathic Parkinson's disease (IPD) and 15 patients with diffuse Lewy body disease (DLBD). The mutations of the CYP 2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis. The rate of genotypically defined PM and the frequencies of the mutation D6-B were not significantly different in IPD and DLBD patients. This study fails to find a relationship between CYP 2D6 impairment and neuropathological lesions diffusion in IPD and DLBD. This study cannot exclude involvement of neuronal expression of CYP 2D6.</div>
</front>
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<Title>Clinical neuropharmacology</Title>
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<ArticleTitle>Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.</ArticleTitle>
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<Abstract><AbstractText>We investigated genetic polymorphism of the cytochrome P450 CYP 2D6 gene in 105 caucasian patients with idiopathic Parkinson's disease (IPD) and 15 patients with diffuse Lewy body disease (DLBD). The mutations of the CYP 2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis. The rate of genotypically defined PM and the frequencies of the mutation D6-B were not significantly different in IPD and DLBD patients. This study fails to find a relationship between CYP 2D6 impairment and neuropathological lesions diffusion in IPD and DLBD. This study cannot exclude involvement of neuronal expression of CYP 2D6.</AbstractText>
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<MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName>
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Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.

Genetic polymorphism of cytochrome P450 2D6 in idiopathic Parkinson disease and diffuse Lewy body disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki