Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
Identifieur interne : 001653 ( PubMed/Corpus ); précédent : 001652; suivant : 001654Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.
Auteurs : P. Horellou ; E. Vigne ; M N Castel ; P. Barnéoud ; P. Colin ; M. Perricaudet ; P. Delaère ; J. MalletSource :
- Neuroreport [ 0959-4965 ] ; 1994.
English descriptors
- KwdEn :
- Adenoviridae (physiology), Animals, Apomorphine (pharmacology), Behavior, Animal (drug effects), Brain (physiopathology), Corpus Striatum (drug effects), Denervation, Female, Gene Transfer Techniques, Genetic Vectors, Oxidopamine (pharmacology), Parkinson Disease (genetics), Parkinson Disease (therapy), Rats, Rats, Sprague-Dawley, Recombination, Genetic, Stereotyped Behavior, Tyrosine 3-Monooxygenase (genetics), beta-Galactosidase (genetics).
- MESH :
- chemical , genetics : Tyrosine 3-Monooxygenase, beta-Galactosidase.
- chemical , pharmacology : Apomorphine, Oxidopamine.
- drug effects : Behavior, Animal, Corpus Striatum.
- genetics : Parkinson Disease.
- physiology : Adenoviridae.
- physiopathology : Brain.
- therapy : Parkinson Disease.
- Animals, Denervation, Female, Gene Transfer Techniques, Genetic Vectors, Rats, Rats, Sprague-Dawley, Recombination, Genetic, Stereotyped Behavior.
Abstract
Direct intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding beta-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase and not by a control adenovirus encoding beta-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.
PubMed: 7703427
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pubmed:7703427Le document en format XML
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Colin</name></author><author><name sortKey="Perricaudet, M" sort="Perricaudet, M" uniqKey="Perricaudet M" first="M" last="Perricaudet">M. Perricaudet</name></author><author><name sortKey="Delaere, P" sort="Delaere, P" uniqKey="Delaere P" first="P" last="Delaère">P. Delaère</name></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J" last="Mallet">J. Mallet</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1994">1994</date><idno type="RBID">pubmed:7703427</idno><idno type="pmid">7703427</idno><idno type="wicri:Area/PubMed/Corpus">001653</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001653</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.</title><author><name sortKey="Horellou, P" sort="Horellou, P" uniqKey="Horellou P" first="P" last="Horellou">P. Horellou</name><affiliation><nlm:affiliation>C 9923 CNRS, Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Dégénératifs, Gif-sur-Yvette, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vigne, E" sort="Vigne, E" uniqKey="Vigne E" first="E" last="Vigne">E. Vigne</name></author><author><name sortKey="Castel, M N" sort="Castel, M N" uniqKey="Castel M" first="M N" last="Castel">M N Castel</name></author><author><name sortKey="Barneoud, P" sort="Barneoud, P" uniqKey="Barneoud P" first="P" last="Barnéoud">P. Barnéoud</name></author><author><name sortKey="Colin, P" sort="Colin, P" uniqKey="Colin P" first="P" last="Colin">P. Colin</name></author><author><name sortKey="Perricaudet, M" sort="Perricaudet, M" uniqKey="Perricaudet M" first="M" last="Perricaudet">M. Perricaudet</name></author><author><name sortKey="Delaere, P" sort="Delaere, P" uniqKey="Delaere P" first="P" last="Delaère">P. Delaère</name></author><author><name sortKey="Mallet, J" sort="Mallet, J" uniqKey="Mallet J" first="J" last="Mallet">J. Mallet</name></author></analytic><series><title level="j">Neuroreport</title><idno type="ISSN">0959-4965</idno><imprint><date when="1994" type="published">1994</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenoviridae (physiology)</term><term>Animals</term><term>Apomorphine (pharmacology)</term><term>Behavior, Animal (drug effects)</term><term>Brain (physiopathology)</term><term>Corpus Striatum (drug effects)</term><term>Denervation</term><term>Female</term><term>Gene Transfer Techniques</term><term>Genetic Vectors</term><term>Oxidopamine (pharmacology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (therapy)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Recombination, Genetic</term><term>Stereotyped Behavior</term><term>Tyrosine 3-Monooxygenase (genetics)</term><term>beta-Galactosidase (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Tyrosine 3-Monooxygenase</term><term>beta-Galactosidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Apomorphine</term><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Behavior, Animal</term><term>Corpus Striatum</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adenoviridae</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Denervation</term><term>Female</term><term>Gene Transfer Techniques</term><term>Genetic Vectors</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Recombination, Genetic</term><term>Stereotyped Behavior</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Direct intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding beta-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase and not by a control adenovirus encoding beta-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">7703427</PMID><DateCreated><Year>1995</Year><Month>05</Month><Day>09</Day></DateCreated><DateCompleted><Year>1995</Year><Month>05</Month><Day>09</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0959-4965</ISSN><JournalIssue CitedMedium="Print"><Volume>6</Volume><Issue>1</Issue><PubDate><Year>1994</Year><Month>Dec</Month><Day>30</Day></PubDate></JournalIssue><Title>Neuroreport</Title><ISOAbbreviation>Neuroreport</ISOAbbreviation></Journal><ArticleTitle>Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>49-53</MedlinePgn></Pagination><Abstract><AbstractText>Direct intracerebral gene transfer to neural cells has been demonstrated with recombinant adenovirus encoding beta-galactosidase. To explore the potential of recombinant adenovirus for the therapy of neurological disease we constructed a recombinant adenovirus encoding tyrosine hydroxylase and optimized intracerebral injection to express the gene in the striatum of unilaterally denervated rats. These animals have dopamine depletion in their lesioned striatum, causing a rotation asymmetry induced by apomorphine. One and two weeks after intracerebral injection this sensorimotor asymmetry was decreased by the adenovirus encoding tyrosine hydroxylase and not by a control adenovirus encoding beta-galactosidase. Histological analysis showed that tyrosine hydroxylase was preferentially expressed in astrocytes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Horellou</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>C 9923 CNRS, Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Dégénératifs, Gif-sur-Yvette, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vigne</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Castel</LastName><ForeName>M N</ForeName><Initials>MN</Initials></Author><Author ValidYN="Y"><LastName>Barnéoud</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Colin</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Perricaudet</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author 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