ParkinsonFranceV1, PubMed, Corpus, bibRecord, 001575

Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.

Identifieur interne : 001575 ( PubMed/Corpus ); précédent : 001574; suivant : 001576

Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.

Auteurs : R. Bordet ; F. Broly ; A. Destée ; C. Libersa ; J J Lafitte

Source :

Clinical neuropharmacology [ 0362-5664 ] ; 1996.

RBID : pubmed:8726540

English descriptors

KwdEn :
- Aged, Bronchitis (genetics), Bronchitis (metabolism), Cytochrome P-450 CYP2D6 (genetics), DNA (genetics), Female, Genotype, Humans, Male, Middle Aged, Mutation, Parkinson Disease (genetics), Parkinson Disease (metabolism), Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length.
MESH :
- chemical , genetics : Cytochrome P-450 CYP2D6, DNA.
- genetics : Bronchitis, Parkinson Disease.
- metabolism : Bronchitis, Parkinson Disease.
- Aged, Female, Genotype, Humans, Male, Middle Aged, Mutation, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length.

Abstract

We investigated genetic polymorphism of the cytochrome P-450 CYP2D6 gene from white patients with idiopathic Parkinson's disease (IPD). The mutations of the CYP2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA of 130 IPD patients by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis in 105 patients. Another mutation located in exon 6 was analyzed by Hha I RFLP in 94 IPD patients. The frequencies of the different CYP2D6 gene mutations were compared to the frequencies in sex- and age-matched white control population with chronic bronchitis. The rate of genotypically defined PM and the frequencies of the different mutations were not significantly different in IPD patients and controls. These results fail to confirm the previously reported results concerning CYP2D6 gene mutations in IPD. These equivocal results might be related to methodologic problems. However, other hypotheses have been suggested: impairment of neuronal CYP 2D6 expression, transient modification of CYP 2D6 phenotype, or linkage of CYP2D6 gene to the candidate gene locus directly involved in IPD.

PubMed: 8726540

Links to Exploration step

pubmed:8726540

Le document en format XML

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<author><name sortKey="Bordet, R" sort="Bordet, R" uniqKey="Bordet R" first="R" last="Bordet">R. Bordet</name>
<affiliation><nlm:affiliation>Service de Neurologie A, CH, Lille, France.</nlm:affiliation>
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<author><name sortKey="Broly, F" sort="Broly, F" uniqKey="Broly F" first="F" last="Broly">F. Broly</name>
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<author><name sortKey="Destee, A" sort="Destee, A" uniqKey="Destee A" first="A" last="Destée">A. Destée</name>
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<author><name sortKey="Libersa, C" sort="Libersa, C" uniqKey="Libersa C" first="C" last="Libersa">C. Libersa</name>
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<author><name sortKey="Lafitte, J J" sort="Lafitte, J J" uniqKey="Lafitte J" first="J J" last="Lafitte">J J Lafitte</name>
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<front><div type="abstract" xml:lang="en">We investigated genetic polymorphism of the cytochrome P-450 CYP2D6 gene from white patients with idiopathic Parkinson's disease (IPD). The mutations of the CYP2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA of 130 IPD patients by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis in 105 patients. Another mutation located in exon 6 was analyzed by Hha I RFLP in 94 IPD patients. The frequencies of the different CYP2D6 gene mutations were compared to the frequencies in sex- and age-matched white control population with chronic bronchitis. The rate of genotypically defined PM and the frequencies of the different mutations were not significantly different in IPD patients and controls. These results fail to confirm the previously reported results concerning CYP2D6 gene mutations in IPD. These equivocal results might be related to methodologic problems. However, other hypotheses have been suggested: impairment of neuronal CYP 2D6 expression, transient modification of CYP 2D6 phenotype, or linkage of CYP2D6 gene to the candidate gene locus directly involved in IPD.</div>
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<Abstract><AbstractText>We investigated genetic polymorphism of the cytochrome P-450 CYP2D6 gene from white patients with idiopathic Parkinson's disease (IPD). The mutations of the CYP2D6 gene associated with the poor metabolizer (PM) phenotype of the debrisoquine/sparteine polymorphism were analyzed in DNA of 130 IPD patients by a polymerase chain reaction (PCR)-based DNA amplification combined with Xba I restriction fragment length polymorphism (RFLP) analysis in 105 patients. Another mutation located in exon 6 was analyzed by Hha I RFLP in 94 IPD patients. The frequencies of the different CYP2D6 gene mutations were compared to the frequencies in sex- and age-matched white control population with chronic bronchitis. The rate of genotypically defined PM and the frequencies of the different mutations were not significantly different in IPD patients and controls. These results fail to confirm the previously reported results concerning CYP2D6 gene mutations in IPD. These equivocal results might be related to methodologic problems. However, other hypotheses have been suggested: impairment of neuronal CYP 2D6 expression, transient modification of CYP 2D6 phenotype, or linkage of CYP2D6 gene to the candidate gene locus directly involved in IPD.</AbstractText>
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Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.

Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki