ParkinsonFranceV1, PubMed, Corpus, bibRecord, 001398

Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group.

Identifieur interne : 001398 ( PubMed/Corpus ); précédent : 001397; suivant : 001399

Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group.

Auteurs : A. Elbaz ; F. Grigoletto ; M. Baldereschi ; M M Breteler ; J M Manubens-Bertran ; S. Lopez-Pousa ; J F Dartigues ; A. Alpérovitch ; C. Tzourio ; W A Rocca

Source :

Neurology [ 0028-3878 ] ; 1999.

RBID : pubmed:10371537

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Case-Control Studies, Europe (epidemiology), Genetics, Population, Humans, Middle Aged, Parkinson Disease (epidemiology), Parkinson Disease (genetics).
MESH :
- geographic , epidemiology : Europe.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Aged, Aged, 80 and over, Case-Control Studies, Genetics, Population, Humans, Middle Aged.

Abstract

To investigate the familial aggregation of PD in a large collaborative population-based case-control study.

PubMed: 10371537

Links to Exploration step

pubmed:10371537

Le document en format XML

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<author><name sortKey="Elbaz, A" sort="Elbaz, A" uniqKey="Elbaz A" first="A" last="Elbaz">A. Elbaz</name>
<affiliation><nlm:affiliation>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière, Paris, France. elbaz@ccr.jussieu.fr</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Grigoletto, F" sort="Grigoletto, F" uniqKey="Grigoletto F" first="F" last="Grigoletto">F. Grigoletto</name>
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<author><name sortKey="Baldereschi, M" sort="Baldereschi, M" uniqKey="Baldereschi M" first="M" last="Baldereschi">M. Baldereschi</name>
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<author><name sortKey="Breteler, M M" sort="Breteler, M M" uniqKey="Breteler M" first="M M" last="Breteler">M M Breteler</name>
</author>
<author><name sortKey="Manubens Bertran, J M" sort="Manubens Bertran, J M" uniqKey="Manubens Bertran J" first="J M" last="Manubens-Bertran">J M Manubens-Bertran</name>
</author>
<author><name sortKey="Lopez Pousa, S" sort="Lopez Pousa, S" uniqKey="Lopez Pousa S" first="S" last="Lopez-Pousa">S. Lopez-Pousa</name>
</author>
<author><name sortKey="Dartigues, J F" sort="Dartigues, J F" uniqKey="Dartigues J" first="J F" last="Dartigues">J F Dartigues</name>
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<author><name sortKey="Alperovitch, A" sort="Alperovitch, A" uniqKey="Alperovitch A" first="A" last="Alpérovitch">A. Alpérovitch</name>
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<author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C" last="Tzourio">C. Tzourio</name>
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<author><name sortKey="Rocca, W A" sort="Rocca, W A" uniqKey="Rocca W" first="W A" last="Rocca">W A Rocca</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group.</title>
<author><name sortKey="Elbaz, A" sort="Elbaz, A" uniqKey="Elbaz A" first="A" last="Elbaz">A. Elbaz</name>
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<author><name sortKey="Grigoletto, F" sort="Grigoletto, F" uniqKey="Grigoletto F" first="F" last="Grigoletto">F. Grigoletto</name>
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<author><name sortKey="Baldereschi, M" sort="Baldereschi, M" uniqKey="Baldereschi M" first="M" last="Baldereschi">M. Baldereschi</name>
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<author><name sortKey="Breteler, M M" sort="Breteler, M M" uniqKey="Breteler M" first="M M" last="Breteler">M M Breteler</name>
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<author><name sortKey="Manubens Bertran, J M" sort="Manubens Bertran, J M" uniqKey="Manubens Bertran J" first="J M" last="Manubens-Bertran">J M Manubens-Bertran</name>
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<author><name sortKey="Lopez Pousa, S" sort="Lopez Pousa, S" uniqKey="Lopez Pousa S" first="S" last="Lopez-Pousa">S. Lopez-Pousa</name>
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<author><name sortKey="Dartigues, J F" sort="Dartigues, J F" uniqKey="Dartigues J" first="J F" last="Dartigues">J F Dartigues</name>
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<author><name sortKey="Alperovitch, A" sort="Alperovitch, A" uniqKey="Alperovitch A" first="A" last="Alpérovitch">A. Alpérovitch</name>
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<author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C" last="Tzourio">C. Tzourio</name>
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<author><name sortKey="Rocca, W A" sort="Rocca, W A" uniqKey="Rocca W" first="W A" last="Rocca">W A Rocca</name>
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<series><title level="j">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="1999" type="published">1999</date>
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<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Europe (epidemiology)</term>
<term>Genetics, Population</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Case-Control Studies</term>
<term>Genetics, Population</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">To investigate the familial aggregation of PD in a large collaborative population-based case-control study.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10371537</PMID>
<DateCreated><Year>1999</Year>
<Month>07</Month>
<Day>15</Day>
</DateCreated>
<DateCompleted><Year>1999</Year>
<Month>07</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised><Year>2007</Year>
<Month>11</Month>
<Day>14</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">0028-3878</ISSN>
<JournalIssue CitedMedium="Print"><Volume>52</Volume>
<Issue>9</Issue>
<PubDate><Year>1999</Year>
<Month>Jun</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
</Journal>
<ArticleTitle>Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group.</ArticleTitle>
<Pagination><MedlinePgn>1876-82</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the familial aggregation of PD in a large collaborative population-based case-control study.</AbstractText>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Most previous case-control studies of the familial aggregation of PD have been hospital- or clinic-based.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We included 219 prevalent cases ascertained in three European populations (centers), using a two-phase design consisting of screening and examination by a neurologist. Each case was matched by age, sex, and center to three controls drawn from the same populations (n = 657). Presence of PD among first-degree relatives (parents and siblings) was determined using the family history approach for 175 cases and 481 controls.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Overall, a positive family history (at least one parent or sibling affected by PD) was reported in 10.3% of patients and 3.5% of controls (odds ratio [OR] = 3.2; 95% confidence interval [CI] = 1.6 to 6.6). A similar association was observed when analyses were restricted to nondemented patients and controls (OR = 3.9; 95% CI = 1.7 to 8.7) or to newly diagnosed patients (OR = 3.3; 95% CI = 0.9 to 11.9). We found a significant trend of increasing risk with increasing number of affected relatives (p = 0.003). Analyses stratified by age showed a stronger association for younger PD patients (OR = 7.6; 95% CI = 1.5 to 38.9) than for older patients (OR = 2.5; 95% CI = 1.1 to 5.7).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this large sample of prevalent PD patients and population-matched controls, PD significantly aggregates in families, with the strength of the association being age-dependent. Therefore, familial factors, which can be genetic, environmental, or both, play a role in PD.</AbstractText>
</Abstract>
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<AffiliationInfo><Affiliation>INSERM U 360, Recherches Epidémiologiques en Neurologie et Psychopathologie, Hôpital de la Salpêtrière, Paris, France. elbaz@ccr.jussieu.fr</Affiliation>
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<Author ValidYN="Y"><LastName>Breteler</LastName>
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<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
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<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group.

Familial aggregation of Parkinson's disease: a population-based case-control study in Europe. EUROPARKINSON Study Group.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki