Trichloroethylene and parkinsonism: a human and experimental observation.
Identifieur interne : 001374 ( PubMed/Corpus ); précédent : 001373; suivant : 001375Trichloroethylene and parkinsonism: a human and experimental observation.
Auteurs : D. Guehl ; E. Bezard ; S. Dovero ; T. Boraud ; B. Bioulac ; C. GrossSource :
- European journal of neurology [ 1351-5101 ] ; 1999.
English descriptors
- KwdEn :
- Animals, Electrodes, Implanted, Female, Globus Pallidus (physiology), Humans, Immunohistochemistry, Mice, Middle Aged, Occupational Exposure (adverse effects), Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (pathology), Parkinson Disease, Secondary (physiopathology), Solvents (adverse effects), Substantia Nigra (pathology), Trichloroethylene (adverse effects).
- MESH :
- chemical , adverse effects : Solvents, Trichloroethylene.
- adverse effects : Occupational Exposure.
- chemically induced : Parkinson Disease, Secondary.
- pathology : Parkinson Disease, Secondary, Substantia Nigra.
- physiology : Globus Pallidus.
- physiopathology : Parkinson Disease, Secondary.
- Animals, Electrodes, Implanted, Female, Humans, Immunohistochemistry, Mice, Middle Aged.
Abstract
This report describes the case of a 47-year-old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were intoxicated with trichloroethylene and tyrosine hydroxylase immunoreactivity was used to measure neuronal death in the substantia nigra pars compacta. Treated mice presented significant dopaminergic neuronal death in comparison with control mice (50%). The environmental trichlorethylene pollution, as well as other unspecific neurotoxic solvents, could potentially contribute to the genesis of some cases of Parkinson's disease.
PubMed: 10457397
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pubmed:10457397Le document en format XML
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<affiliation><nlm:affiliation>Basal Gang, Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique UMR 5543, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux Cedex, Cedex, France.</nlm:affiliation>
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<author><name sortKey="Bezard, E" sort="Bezard, E" uniqKey="Bezard E" first="E" last="Bezard">E. Bezard</name>
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<author><name sortKey="Dovero, S" sort="Dovero, S" uniqKey="Dovero S" first="S" last="Dovero">S. Dovero</name>
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<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
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<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
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<author><name sortKey="Gross, C" sort="Gross, C" uniqKey="Gross C" first="C" last="Gross">C. Gross</name>
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<affiliation><nlm:affiliation>Basal Gang, Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique UMR 5543, Universite de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux Cedex, Cedex, France.</nlm:affiliation>
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<author><name sortKey="Boraud, T" sort="Boraud, T" uniqKey="Boraud T" first="T" last="Boraud">T. Boraud</name>
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<author><name sortKey="Bioulac, B" sort="Bioulac, B" uniqKey="Bioulac B" first="B" last="Bioulac">B. Bioulac</name>
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<series><title level="j">European journal of neurology</title>
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<term>Electrodes, Implanted</term>
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<term>Globus Pallidus (physiology)</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Mice</term>
<term>Middle Aged</term>
<term>Occupational Exposure (adverse effects)</term>
<term>Parkinson Disease, Secondary (chemically induced)</term>
<term>Parkinson Disease, Secondary (pathology)</term>
<term>Parkinson Disease, Secondary (physiopathology)</term>
<term>Solvents (adverse effects)</term>
<term>Substantia Nigra (pathology)</term>
<term>Trichloroethylene (adverse effects)</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease, Secondary</term>
<term>Substantia Nigra</term>
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<term>Electrodes, Implanted</term>
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<front><div type="abstract" xml:lang="en">This report describes the case of a 47-year-old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were intoxicated with trichloroethylene and tyrosine hydroxylase immunoreactivity was used to measure neuronal death in the substantia nigra pars compacta. Treated mice presented significant dopaminergic neuronal death in comparison with control mice (50%). The environmental trichlorethylene pollution, as well as other unspecific neurotoxic solvents, could potentially contribute to the genesis of some cases of Parkinson's disease.</div>
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<Title>European journal of neurology</Title>
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<ArticleTitle>Trichloroethylene and parkinsonism: a human and experimental observation.</ArticleTitle>
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<Abstract><AbstractText>This report describes the case of a 47-year-old woman who developed Parkinson's disease after seven years of professional exposure to trichloroethylene. In the light of this clinical report, mice were intoxicated with trichloroethylene and tyrosine hydroxylase immunoreactivity was used to measure neuronal death in the substantia nigra pars compacta. Treated mice presented significant dopaminergic neuronal death in comparison with control mice (50%). The environmental trichlorethylene pollution, as well as other unspecific neurotoxic solvents, could potentially contribute to the genesis of some cases of Parkinson's disease.</AbstractText>
<CopyrightInformation>Copyright Lippincott Williams & Wilkins</CopyrightInformation>
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