Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease.
Identifieur interne : 001229 ( PubMed/Corpus ); précédent : 001228; suivant : 001230Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease.
Auteurs : S. Thobois ; S. Guillouet ; E. BroussolleSource :
- Neurophysiologie clinique = Clinical neurophysiology [ 0987-7053 ] ; 2001.
English descriptors
- KwdEn :
- Aging (metabolism), Animals, Antiparkinson Agents (pharmacology), Antiparkinson Agents (therapeutic use), Basal Ganglia (diagnostic imaging), Basal Ganglia (metabolism), Basal Ganglia (physiopathology), Basal Ganglia (surgery), Brain Tissue Transplantation, Cell Transplantation, Cerebrovascular Circulation, Diagnosis, Differential, Dihydroxyphenylalanine (analogs & derivatives), Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Electric Stimulation Therapy, Fetal Tissue Transplantation, Forecasting, Genetic Predisposition to Disease, Humans, Iatrogenic Disease, Imagination, Ligands, Mesencephalon (cytology), Mesencephalon (embryology), Motor Activity, Nerve Degeneration (diagnostic imaging), Neurodegenerative Diseases (diagnosis), Neurons (transplantation), Neuroprotective Agents (pharmacology), Neuroprotective Agents (therapeutic use), Neurotransmitter Agents (metabolism), Parkinson Disease (diagnosis), Parkinson Disease (diagnostic imaging), Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Parkinson Disease, Secondary (diagnostic imaging), Parkinsonian Disorders (diagnostic imaging), Radiopharmaceuticals, Rats, Receptors, Dopamine (metabolism), Risk, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon, Tremor (diagnostic imaging).
- MESH :
- chemical , analogs & derivatives : Dihydroxyphenylalanine.
- chemical , metabolism : Neurotransmitter Agents, Receptors, Dopamine.
- chemical , pharmacology : Antiparkinson Agents, Dopamine Agonists, Neuroprotective Agents.
- cytology : Mesencephalon.
- diagnosis : Neurodegenerative Diseases, Parkinson Disease.
- diagnostic imaging : Basal Ganglia, Nerve Degeneration, Parkinson Disease, Parkinson Disease, Secondary, Parkinsonian Disorders, Tremor.
- embryology : Mesencephalon.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease.
- metabolism : Aging, Basal Ganglia.
- physiopathology : Basal Ganglia, Parkinson Disease.
- surgery : Basal Ganglia.
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agonists, Neuroprotective Agents.
- therapy : Parkinson Disease.
- transplantation : Neurons.
- Animals, Brain Tissue Transplantation, Cell Transplantation, Cerebrovascular Circulation, Diagnosis, Differential, Electric Stimulation Therapy, Fetal Tissue Transplantation, Forecasting, Genetic Predisposition to Disease, Humans, Iatrogenic Disease, Imagination, Ligands, Motor Activity, Radiopharmaceuticals, Rats, Risk, Tomography, Emission-Computed, Tomography, Emission-Computed, Single-Photon.
Abstract
Positron emission tomography (PET) and single photon emission computed tomography (SPECT) provide the means to studying in vivo the neurochemical, hemodynamic or metabolic consequences of the degeneration of the nigrostriatal dopaminergic system in Parkinson's disease (PD). The extent of striatal dopaminergic denervation can be quantified with radiotracers as [18F]FDopa for PET and [123I]tropanes for SPECT. There are other radiotracers such as [11C]Dopa and meta-tyrosines as well as PET tracers for uptake sites. Striatal uptake of [18F]FDopa and [123I]tropanes is markedly decreased in PD, more in the putamen than in the caudate nucleus, and inversely correlates with the severity of motor signs and with duration of disease. PET and SPECT make possible the assessment by noninvasive means of the changes in dopamine receptor density, the effect of neuronal transplants or neuroprotective treatments in PD patients, or the nigrostriatal dopaminergic function in at-risk subjects. Activation studies using cerebral blood flow and metabolism measurements during a motor task reveal an impaired ability to activate the supplementary motor area and dorsolateral prefrontal cortex in PD. This functional disability is reversed by the use of dopaminergic medication or by surgical treatment by pallidotomy or deep brain stimulation. The differential diagnosis between PD and multiple system atrophy, progressive supranuclear palsy or corticobasal degeneration is not yet clearly established by PET and SPECT, even though these syndromes have some particular neurochemical and metabolic profiles. On the other hand, PET and SPECT are useful for distinguishing PD from Dopa-responsive dystonia, or for assessing the integrity of the nigrostriatal dopaminergic pathway in atypical cases of postural tremor or iatrogenic parkinsonian syndromes.
PubMed: 11817273
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pubmed:11817273Le document en format XML
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type="abstract" xml:lang="en">Positron emission tomography (PET) and single photon emission computed tomography (SPECT) provide the means to studying in vivo the neurochemical, hemodynamic or metabolic consequences of the degeneration of the nigrostriatal dopaminergic system in Parkinson's disease (PD). The extent of striatal dopaminergic denervation can be quantified with radiotracers as [18F]FDopa for PET and [123I]tropanes for SPECT. There are other radiotracers such as [11C]Dopa and meta-tyrosines as well as PET tracers for uptake sites. Striatal uptake of [18F]FDopa and [123I]tropanes is markedly decreased in PD, more in the putamen than in the caudate nucleus, and inversely correlates with the severity of motor signs and with duration of disease. PET and SPECT make possible the assessment by noninvasive means of the changes in dopamine receptor density, the effect of neuronal transplants or neuroprotective treatments in PD patients, or the nigrostriatal dopaminergic function in at-risk subjects. Activation studies using cerebral blood flow and metabolism measurements during a motor task reveal an impaired ability to activate the supplementary motor area and dorsolateral prefrontal cortex in PD. This functional disability is reversed by the use of dopaminergic medication or by surgical treatment by pallidotomy or deep brain stimulation. The differential diagnosis between PD and multiple system atrophy, progressive supranuclear palsy or corticobasal degeneration is not yet clearly established by PET and SPECT, even though these syndromes have some particular neurochemical and metabolic profiles. On the other hand, PET and SPECT are useful for distinguishing PD from Dopa-responsive dystonia, or for assessing the integrity of the nigrostriatal dopaminergic pathway in atypical cases of postural tremor or iatrogenic parkinsonian syndromes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11817273</PMID><DateCreated><Year>2001</Year><Month>12</Month><Day>05</Day></DateCreated><DateCompleted><Year>2002</Year><Month>01</Month><Day>30</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0987-7053</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>5</Issue><PubDate><Year>2001</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Neurophysiologie clinique = Clinical neurophysiology</Title><ISOAbbreviation>Neurophysiol Clin</ISOAbbreviation></Journal><ArticleTitle>Contributions of PET and SPECT to the understanding of the pathophysiology of Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>321-40</MedlinePgn></Pagination><Abstract><AbstractText>Positron emission tomography (PET) and single photon emission computed tomography (SPECT) provide the means to studying in vivo the neurochemical, hemodynamic or metabolic consequences of the degeneration of the nigrostriatal dopaminergic system in Parkinson's disease (PD). The extent of striatal dopaminergic denervation can be quantified with radiotracers as [18F]FDopa for PET and [123I]tropanes for SPECT. There are other radiotracers such as [11C]Dopa and meta-tyrosines as well as PET tracers for uptake sites. Striatal uptake of [18F]FDopa and [123I]tropanes is markedly decreased in PD, more in the putamen than in the caudate nucleus, and inversely correlates with the severity of motor signs and with duration of disease. PET and SPECT make possible the assessment by noninvasive means of the changes in dopamine receptor density, the effect of neuronal transplants or neuroprotective treatments in PD patients, or the nigrostriatal dopaminergic function in at-risk subjects. Activation studies using cerebral blood flow and metabolism measurements during a motor task reveal an impaired ability to activate the supplementary motor area and dorsolateral prefrontal cortex in PD. This functional disability is reversed by the use of dopaminergic medication or by surgical treatment by pallidotomy or deep brain stimulation. The differential diagnosis between PD and multiple system atrophy, progressive supranuclear palsy or corticobasal degeneration is not yet clearly established by PET and SPECT, even though these syndromes have some particular neurochemical and metabolic profiles. On the other hand, PET and SPECT are useful for distinguishing PD from Dopa-responsive dystonia, or for assessing the integrity of the nigrostriatal dopaminergic pathway in atypical cases of postural tremor or iatrogenic parkinsonian syndromes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thobois</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>CERMEP et service de neurologie D, hôpital neurologique Pierre-Wertheimer, 59, boulevard Pinel, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guillouet</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Broussolle</LastName><ForeName>E</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Neurophysiol Clin</MedlineTA><NlmUniqueID>8804532</NlmUniqueID><ISSNLinking>0987-7053</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018491">Dopamine Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008024">Ligands</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018696">Neuroprotective Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018377">Neurotransmitter Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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UI="D007049" MajorTopicYN="N">Iatrogenic Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007092" MajorTopicYN="N">Imagination</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008024" MajorTopicYN="N">Ligands</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008636" MajorTopicYN="N">Mesencephalon</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000196" MajorTopicYN="N">embryology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009043" MajorTopicYN="N">Motor Activity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009410" MajorTopicYN="N">Nerve Degeneration</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName><QualifierName UI="Q000175" 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MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014055" MajorTopicYN="Y">Tomography, Emission-Computed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015899" MajorTopicYN="Y">Tomography, Emission-Computed, Single-Photon</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014202" MajorTopicYN="N">Tremor</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>160</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>1</Month><Day>31</Day><Hour>10</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2002</Year><Month>1</Month><Day>31</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate 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