Neurodegenerative diseases and exposure to pesticides in the elderly.
Identifieur interne : 001115 ( PubMed/Corpus ); précédent : 001114; suivant : 001116Neurodegenerative diseases and exposure to pesticides in the elderly.
Auteurs : Isabelle Baldi ; Pierre Lebailly ; Brahim Mohammed-Brahim ; Luc Letenneur ; Jean-François Dartigues ; Patrick BrochardSource :
- American journal of epidemiology [ 0002-9262 ] ; 2003.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Agricultural Workers' Diseases (chemically induced), Agricultural Workers' Diseases (epidemiology), Alzheimer Disease (chemically induced), Alzheimer Disease (epidemiology), Cognition Disorders (chemically induced), Cognition Disorders (epidemiology), Confounding Factors (Epidemiology), Cross-Sectional Studies, Environmental Exposure (adverse effects), Female, France (epidemiology), Humans, Incidence, Male, Occupational Exposure (adverse effects), Parkinson Disease (epidemiology), Parkinson Disease (etiology), Pesticides (adverse effects), Proportional Hazards Models, Risk Factors, Surveys and Questionnaires.
- MESH :
- chemical , adverse effects : Pesticides.
- geographic , epidemiology : France.
- adverse effects : Environmental Exposure, Occupational Exposure.
- chemically induced : Agricultural Workers' Diseases, Alzheimer Disease, Cognition Disorders.
- epidemiology : Agricultural Workers' Diseases, Alzheimer Disease, Cognition Disorders, Parkinson Disease.
- etiology : Parkinson Disease.
- Aged, Aged, 80 and over, Confounding Factors (Epidemiology), Cross-Sectional Studies, Female, Humans, Incidence, Male, Proportional Hazards Models, Risk Factors, Surveys and Questionnaires.
Abstract
The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992-1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson's disease and Alzheimer's disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.
PubMed: 12615605
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Letenneur</name></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name></author><author><name sortKey="Brochard, Patrick" sort="Brochard, Patrick" uniqKey="Brochard P" first="Patrick" last="Brochard">Patrick Brochard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12615605</idno><idno type="pmid">12615605</idno><idno type="wicri:Area/PubMed/Corpus">001115</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001115</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neurodegenerative diseases and exposure to pesticides in the elderly.</title><author><name sortKey="Baldi, Isabelle" sort="Baldi, Isabelle" uniqKey="Baldi I" first="Isabelle" last="Baldi">Isabelle Baldi</name><affiliation><nlm:affiliation>Laboratoire Santé Travail Environnement, Institut de Santé Publique d'Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France. isabelle.baldi@isped.u-bordeaux2.fr</nlm:affiliation></affiliation></author><author><name sortKey="Lebailly, Pierre" sort="Lebailly, Pierre" uniqKey="Lebailly P" first="Pierre" last="Lebailly">Pierre Lebailly</name></author><author><name sortKey="Mohammed Brahim, Brahim" sort="Mohammed Brahim, Brahim" uniqKey="Mohammed Brahim B" first="Brahim" last="Mohammed-Brahim">Brahim Mohammed-Brahim</name></author><author><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name></author><author><name sortKey="Brochard, Patrick" sort="Brochard, Patrick" uniqKey="Brochard P" first="Patrick" last="Brochard">Patrick Brochard</name></author></analytic><series><title level="j">American journal of epidemiology</title><idno type="ISSN">0002-9262</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Agricultural Workers' Diseases (chemically induced)</term><term>Agricultural Workers' Diseases (epidemiology)</term><term>Alzheimer Disease (chemically induced)</term><term>Alzheimer Disease (epidemiology)</term><term>Cognition Disorders (chemically induced)</term><term>Cognition Disorders (epidemiology)</term><term>Confounding Factors (Epidemiology)</term><term>Cross-Sectional Studies</term><term>Environmental Exposure (adverse effects)</term><term>Female</term><term>France (epidemiology)</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Occupational Exposure (adverse effects)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (etiology)</term><term>Pesticides (adverse effects)</term><term>Proportional Hazards Models</term><term>Risk Factors</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Alzheimer Disease</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Agricultural Workers' Diseases</term><term>Alzheimer Disease</term><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Confounding Factors (Epidemiology)</term><term>Cross-Sectional Studies</term><term>Female</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Proportional Hazards Models</term><term>Risk Factors</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992-1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson's disease and Alzheimer's disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12615605</PMID><DateCreated><Year>2003</Year><Month>03</Month><Day>04</Day></DateCreated><DateCompleted><Year>2003</Year><Month>03</Month><Day>27</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-9262</ISSN><JournalIssue CitedMedium="Print"><Volume>157</Volume><Issue>5</Issue><PubDate><Year>2003</Year><Month>Mar</Month><Day>01</Day></PubDate></JournalIssue><Title>American journal of epidemiology</Title><ISOAbbreviation>Am. J. Epidemiol.</ISOAbbreviation></Journal><ArticleTitle>Neurodegenerative diseases and exposure to pesticides in the elderly.</ArticleTitle><Pagination><MedlinePgn>409-14</MedlinePgn></Pagination><Abstract><AbstractText>The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992-1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson's disease and Alzheimer's disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Baldi</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Laboratoire Santé Travail Environnement, Institut de Santé Publique d'Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France. isabelle.baldi@isped.u-bordeaux2.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lebailly</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Mohammed-Brahim</LastName><ForeName>Brahim</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Letenneur</LastName><ForeName>Luc</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Dartigues</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials></Author><Author 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