A computer model of rigidity and related motor dysfunction in Parkinson's disease.
Identifieur interne : 001070 ( PubMed/Corpus ); précédent : 001069; suivant : 001071A computer model of rigidity and related motor dysfunction in Parkinson's disease.
Auteurs : Philippe Le Cavorzin ; Guy Carrault ; Francis Chagneau ; Pierre Rochcongar ; Hervé AllainSource :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2003.
English descriptors
- KwdEn :
- Computer Simulation, Electromyography (instrumentation), Humans, Models, Biological, Muscle Rigidity (diagnosis), Muscle Rigidity (etiology), Neural Networks (Computer), Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Proprioception (physiology), Reflex, Stretch (physiology), Spinal Cord (physiopathology), Time Factors.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Muscle Rigidity, Parkinson Disease.
- etiology : Muscle Rigidity.
- instrumentation : Electromyography.
- physiology : Proprioception, Reflex, Stretch.
- physiopathology : Parkinson Disease, Spinal Cord.
- Computer Simulation, Humans, Models, Biological, Neural Networks (Computer), Time Factors.
Abstract
This work explores the involvement of spinal circuits in the generation of parkinsonian rigidity and related motor dysfunction. A computer model of spinal proprioceptive input processing, derived from previous work on spasticity modeling, was adapted to the simulation of parkinsonian rigidity. Model parameters were varied to generate simulations reproducing experimental data obtained using the pendulum test of the leg in 10 parkinsonian patients and 3 healthy subjects. Convenient reproductions of experimental traces in rigidity were obtained by the combination of a low reflex gain and a decrease in reflex threshold. These findings are consistent with studies reporting an increase of spinal interneuron excitability and proprioception deficits in Parkinson's disease (PD). Moreover, as the threshold parameter was much lowered, our model generated typical features of parkinsonian resting tremor, endorsing the hypothesis of a participation of a spinal oscillator in this disorder. Finally, tuning the reflex gain during simulations of rigidity resulted in the generation of active movement, opening some hypotheses on pathophysiology of motor dysfunction in PD, and notably, of akinesia. More generally, this work accredits the hypothesis of the involvement of an aperiodic, altered supra-spinal motor drive in PD, resulting in spinal dysfunction, through specific descending motor pathways. This may lead to a search for new (spinal) pharmacological targets in PD. It emphasizes further the value of computer modeling in understanding motor control in health and disease.
DOI: 10.1002/mds.10532
PubMed: 14639665
Links to Exploration step
pubmed:14639665Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A computer model of rigidity and related motor dysfunction in Parkinson's disease.</title><author><name sortKey="Le Cavorzin, Philippe" sort="Le Cavorzin, Philippe" uniqKey="Le Cavorzin P" first="Philippe" last="Le Cavorzin">Philippe Le Cavorzin</name><affiliation><nlm:affiliation>Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine de Rennes, Rennes, France. philippe.lecavorzin@free.fr</nlm:affiliation></affiliation></author><author><name sortKey="Carrault, Guy" sort="Carrault, Guy" uniqKey="Carrault G" first="Guy" last="Carrault">Guy Carrault</name></author><author><name sortKey="Chagneau, Francis" sort="Chagneau, Francis" uniqKey="Chagneau F" first="Francis" last="Chagneau">Francis Chagneau</name></author><author><name sortKey="Rochcongar, Pierre" sort="Rochcongar, Pierre" uniqKey="Rochcongar P" first="Pierre" last="Rochcongar">Pierre Rochcongar</name></author><author><name sortKey="Allain, Herve" sort="Allain, Herve" uniqKey="Allain H" first="Hervé" last="Allain">Hervé Allain</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14639665</idno><idno type="pmid">14639665</idno><idno type="doi">10.1002/mds.10532</idno><idno type="wicri:Area/PubMed/Corpus">001070</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001070</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A computer model of rigidity and related motor dysfunction in Parkinson's disease.</title><author><name sortKey="Le Cavorzin, Philippe" sort="Le Cavorzin, Philippe" uniqKey="Le Cavorzin P" first="Philippe" last="Le Cavorzin">Philippe Le Cavorzin</name><affiliation><nlm:affiliation>Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine de Rennes, Rennes, France. philippe.lecavorzin@free.fr</nlm:affiliation></affiliation></author><author><name sortKey="Carrault, Guy" sort="Carrault, Guy" uniqKey="Carrault G" first="Guy" last="Carrault">Guy Carrault</name></author><author><name sortKey="Chagneau, Francis" sort="Chagneau, Francis" uniqKey="Chagneau F" first="Francis" last="Chagneau">Francis Chagneau</name></author><author><name sortKey="Rochcongar, Pierre" sort="Rochcongar, Pierre" uniqKey="Rochcongar P" first="Pierre" last="Rochcongar">Pierre Rochcongar</name></author><author><name sortKey="Allain, Herve" sort="Allain, Herve" uniqKey="Allain H" first="Hervé" last="Allain">Hervé Allain</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Computer Simulation</term><term>Electromyography (instrumentation)</term><term>Humans</term><term>Models, Biological</term><term>Muscle Rigidity (diagnosis)</term><term>Muscle Rigidity (etiology)</term><term>Neural Networks (Computer)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Proprioception (physiology)</term><term>Reflex, Stretch (physiology)</term><term>Spinal Cord (physiopathology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Muscle Rigidity</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Muscle Rigidity</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Electromyography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Proprioception</term><term>Reflex, Stretch</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Spinal Cord</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Computer Simulation</term><term>Humans</term><term>Models, Biological</term><term>Neural Networks (Computer)</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This work explores the involvement of spinal circuits in the generation of parkinsonian rigidity and related motor dysfunction. A computer model of spinal proprioceptive input processing, derived from previous work on spasticity modeling, was adapted to the simulation of parkinsonian rigidity. Model parameters were varied to generate simulations reproducing experimental data obtained using the pendulum test of the leg in 10 parkinsonian patients and 3 healthy subjects. Convenient reproductions of experimental traces in rigidity were obtained by the combination of a low reflex gain and a decrease in reflex threshold. These findings are consistent with studies reporting an increase of spinal interneuron excitability and proprioception deficits in Parkinson's disease (PD). Moreover, as the threshold parameter was much lowered, our model generated typical features of parkinsonian resting tremor, endorsing the hypothesis of a participation of a spinal oscillator in this disorder. Finally, tuning the reflex gain during simulations of rigidity resulted in the generation of active movement, opening some hypotheses on pathophysiology of motor dysfunction in PD, and notably, of akinesia. More generally, this work accredits the hypothesis of the involvement of an aperiodic, altered supra-spinal motor drive in PD, resulting in spinal dysfunction, through specific descending motor pathways. This may lead to a search for new (spinal) pharmacological targets in PD. It emphasizes further the value of computer modeling in understanding motor control in health and disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14639665</PMID><DateCreated><Year>2003</Year><Month>11</Month><Day>25</Day></DateCreated><DateCompleted><Year>2004</Year><Month>03</Month><Day>25</Day></DateCompleted><DateRevised><Year>2004</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0885-3185</ISSN><JournalIssue CitedMedium="Print"><Volume>18</Volume><Issue>11</Issue><PubDate><Year>2003</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>A computer model of rigidity and related motor dysfunction in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1257-65</MedlinePgn></Pagination><Abstract><AbstractText>This work explores the involvement of spinal circuits in the generation of parkinsonian rigidity and related motor dysfunction. A computer model of spinal proprioceptive input processing, derived from previous work on spasticity modeling, was adapted to the simulation of parkinsonian rigidity. Model parameters were varied to generate simulations reproducing experimental data obtained using the pendulum test of the leg in 10 parkinsonian patients and 3 healthy subjects. Convenient reproductions of experimental traces in rigidity were obtained by the combination of a low reflex gain and a decrease in reflex threshold. These findings are consistent with studies reporting an increase of spinal interneuron excitability and proprioception deficits in Parkinson's disease (PD). Moreover, as the threshold parameter was much lowered, our model generated typical features of parkinsonian resting tremor, endorsing the hypothesis of a participation of a spinal oscillator in this disorder. Finally, tuning the reflex gain during simulations of rigidity resulted in the generation of active movement, opening some hypotheses on pathophysiology of motor dysfunction in PD, and notably, of akinesia. More generally, this work accredits the hypothesis of the involvement of an aperiodic, altered supra-spinal motor drive in PD, resulting in spinal dysfunction, through specific descending motor pathways. This may lead to a search for new (spinal) pharmacological targets in PD. It emphasizes further the value of computer modeling in understanding motor control in health and disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Le Cavorzin</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire de Pharmacologie Expérimentale et Clinique, Faculté de Médecine de Rennes, Rennes, France. philippe.lecavorzin@free.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrault</LastName><ForeName>Guy</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Chagneau</LastName><ForeName>Francis</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Rochcongar</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Allain</LastName><ForeName>Hervé</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D003198" MajorTopicYN="Y">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004576" MajorTopicYN="N">Electromyography</DescriptorName><QualifierName UI="Q000295" MajorTopicYN="N">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008954" MajorTopicYN="Y">Models, Biological</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009127" MajorTopicYN="N">Muscle Rigidity</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016571" MajorTopicYN="Y">Neural Networks (Computer)</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011434" MajorTopicYN="N">Proprioception</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012026" MajorTopicYN="N">Reflex, Stretch</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013116" MajorTopicYN="N">Spinal Cord</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>11</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>3</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>11</Month><Day>26</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14639665</ArticleId><ArticleId IdType="doi">10.1002/mds.10532</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001070 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001070 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:14639665
|texte= A computer model of rigidity and related motor dysfunction in Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:14639665" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |