Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.
Identifieur interne : 001067 ( PubMed/Corpus ); précédent : 001066; suivant : 001068Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.
Auteurs : Paul Krack ; Alina Batir ; Nadège Van Blercom ; Stephan Chabardes ; Valérie Fraix ; Claire Ardouin ; Adnan Koudsie ; Patricia Dowsey Limousin ; Abdelhamid Benazzouz ; Jean François Lebas ; Alim-Louis Benabid ; Pierre PollakSource :
- The New England journal of medicine [ 1533-4406 ] ; 2003.
English descriptors
- KwdEn :
- Activities of Daily Living, Adult, Aged, Antiparkinson Agents (therapeutic use), Combined Modality Therapy, Dyskinesia, Drug-Induced (etiology), Electric Stimulation Therapy (adverse effects), Electrodes, Implanted, Female, Follow-Up Studies, Functional Laterality, Humans, Levodopa (therapeutic use), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (classification), Parkinson Disease (drug therapy), Parkinson Disease (psychology), Parkinson Disease (therapy), Severity of Illness Index, Subthalamic Nucleus (physiology), Subthalamic Nucleus (surgery).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- adverse effects : Electric Stimulation Therapy.
- classification : Parkinson Disease.
- drug therapy : Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- physiology : Subthalamic Nucleus.
- psychology : Parkinson Disease.
- surgery : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Activities of Daily Living, Adult, Aged, Combined Modality Therapy, Electrodes, Implanted, Female, Follow-Up Studies, Functional Laterality, Humans, Male, Middle Aged, Neuropsychological Tests, Severity of Illness Index.
Abstract
Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown.
DOI: 10.1056/NEJMoa035275
PubMed: 14614167
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uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name></author><author><name sortKey="Koudsie, Adnan" sort="Koudsie, Adnan" uniqKey="Koudsie A" first="Adnan" last="Koudsie">Adnan Koudsie</name></author><author><name sortKey="Limousin, Patricia Dowsey" sort="Limousin, Patricia Dowsey" uniqKey="Limousin P" first="Patricia Dowsey" last="Limousin">Patricia Dowsey Limousin</name></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name></author><author><name sortKey="Lebas, Jean Francois" sort="Lebas, Jean Francois" uniqKey="Lebas J" first="Jean François" last="Lebas">Jean François Lebas</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14614167</idno><idno type="pmid">14614167</idno><idno type="doi">10.1056/NEJMoa035275</idno><idno type="wicri:Area/PubMed/Corpus">001067</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001067</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.</title><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><nlm:affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France. paul.krack@ujf-grenoble.fr</nlm:affiliation></affiliation></author><author><name sortKey="Batir, Alina" sort="Batir, Alina" uniqKey="Batir A" first="Alina" last="Batir">Alina Batir</name></author><author><name sortKey="Van Blercom, Nadege" sort="Van Blercom, Nadege" uniqKey="Van Blercom N" first="Nadège" last="Van Blercom">Nadège Van Blercom</name></author><author><name sortKey="Chabardes, Stephan" sort="Chabardes, Stephan" uniqKey="Chabardes S" first="Stephan" last="Chabardes">Stephan Chabardes</name></author><author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valérie" last="Fraix">Valérie Fraix</name></author><author><name sortKey="Ardouin, Claire" sort="Ardouin, Claire" uniqKey="Ardouin C" first="Claire" last="Ardouin">Claire Ardouin</name></author><author><name sortKey="Koudsie, Adnan" sort="Koudsie, Adnan" uniqKey="Koudsie A" first="Adnan" last="Koudsie">Adnan Koudsie</name></author><author><name sortKey="Limousin, Patricia Dowsey" sort="Limousin, Patricia Dowsey" uniqKey="Limousin P" first="Patricia Dowsey" last="Limousin">Patricia Dowsey Limousin</name></author><author><name sortKey="Benazzouz, Abdelhamid" sort="Benazzouz, Abdelhamid" uniqKey="Benazzouz A" first="Abdelhamid" last="Benazzouz">Abdelhamid Benazzouz</name></author><author><name sortKey="Lebas, Jean Francois" sort="Lebas, Jean Francois" uniqKey="Lebas J" first="Jean François" last="Lebas">Jean François Lebas</name></author><author><name sortKey="Benabid, Alim Louis" sort="Benabid, Alim Louis" uniqKey="Benabid A" first="Alim-Louis" last="Benabid">Alim-Louis Benabid</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Aged</term><term>Antiparkinson Agents (therapeutic use)</term><term>Combined Modality Therapy</term><term>Dyskinesia, Drug-Induced (etiology)</term><term>Electric Stimulation Therapy (adverse effects)</term><term>Electrodes, Implanted</term><term>Female</term><term>Follow-Up Studies</term><term>Functional Laterality</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (classification)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (psychology)</term><term>Parkinson Disease (therapy)</term><term>Severity of Illness Index</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic Nucleus (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Electric Stimulation Therapy</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Adult</term><term>Aged</term><term>Combined Modality Therapy</term><term>Electrodes, Implanted</term><term>Female</term><term>Follow-Up Studies</term><term>Functional Laterality</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14614167</PMID><DateCreated><Year>2003</Year><Month>11</Month><Day>17</Day></DateCreated><DateCompleted><Year>2003</Year><Month>11</Month><Day>24</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>349</Volume><Issue>20</Issue><PubDate><Year>2003</Year><Month>Nov</Month><Day>13</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation></Journal><ArticleTitle>Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1925-34</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a five-year prospective study of the first 49 consecutive patients whom we treated with bilateral stimulation of the subthalamic nucleus. Patients were assessed at one, three, and five years with levodopa (on medication) and without levodopa (off medication), with use of the Unified Parkinson's Disease Rating Scale. Seven patients did not complete the study: three died, and four were lost to follow-up.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">As compared with base line, the patients' scores at five years for motor function while off medication improved by 54 percent (P<0.001) and those for activities of daily living improved by 49 percent (P<0.001). Speech was the only motor function for which off-medication scores did not improve. The scores for motor function on medication did not improve one year after surgery, except for the dyskinesia scores. On-medication akinesia, speech, postural stability, and freezing of gait worsened between year 1 and year 5 (P<0.001 for all comparisons). At five years, the dose of dopaminergic treatment and the duration and severity of levodopa-induced dyskinesia were reduced, as compared with base line (P<0.001 for each comparison). The average scores for cognitive performance remained unchanged, but dementia developed in three patients after three years. Mean depression scores remained unchanged. Severe adverse events included a large intracerebral hemorrhage in one patient. One patient committed suicide.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients with advanced Parkinson's disease who were treated with bilateral stimulation of the subthalamic nucleus had marked improvements over five years in motor function while off medication and in dyskinesia while on medication. There was no control group, but worsening of akinesia, speech, postural stability, freezing of gait, and cognitive function between the first and the fifth year is consistent with the natural history of Parkinson's disease.</AbstractText><CopyrightInformation>Copyright 2003 Massachusetts Medical Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krack</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France. paul.krack@ujf-grenoble.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Batir</LastName><ForeName>Alina</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Van Blercom</LastName><ForeName>Nadège</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Chabardes</LastName><ForeName>Stephan</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Fraix</LastName><ForeName>Valérie</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ardouin</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Koudsie</LastName><ForeName>Adnan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Limousin</LastName><ForeName>Patricia Dowsey</ForeName><Initials>PD</Initials></Author><Author ValidYN="Y"><LastName>Benazzouz</LastName><ForeName>Abdelhamid</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>LeBas</LastName><ForeName>Jean François</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Benabid</LastName><ForeName>Alim-Louis</ForeName><Initials>AL</Initials></Author><Author ValidYN="Y"><LastName>Pollak</LastName><ForeName>Pierre</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>N Engl J Med</MedlineTA><NlmUniqueID>0255562</NlmUniqueID><ISSNLinking>0028-4793</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2003 Nov 13;349(20):1888-91</RefSource><PMID Version="1">14614163</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000203" MajorTopicYN="N">Activities of Daily Living</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="Y">Electric Stimulation Therapy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004567" MajorTopicYN="N">Electrodes, Implanted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007839" MajorTopicYN="N">Functional Laterality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="Y">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>11</Month><Day>14</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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