Clozapine improves dyskinesias in Parkinson disease: a double-blind, placebo-controlled study.
Identifieur interne : 001037 ( PubMed/Corpus ); précédent : 001036; suivant : 001038Clozapine improves dyskinesias in Parkinson disease: a double-blind, placebo-controlled study.
Auteurs : F. Durif ; B. Debilly ; M. Galitzky ; D. Morand ; F. Viallet ; M. Borg ; S. Thobois ; E. Broussolle ; O. RascolSource :
- Neurology [ 1526-632X ] ; 2004.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Clozapine (therapeutic use), Double-Blind Method, Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (etiology), Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Serotonin Receptor Agonists (therapeutic use), Treatment Outcome.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , therapeutic use : Antiparkinson Agents, Clozapine, Levodopa, Serotonin Receptor Agonists.
- complications : Parkinson Disease.
- drug therapy : Dyskinesia, Drug-Induced, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced.
- Aged, Double-Blind Method, Humans, Middle Aged, Treatment Outcome.
Abstract
To investigate the efficacy and safety of clozapine in the treatment of levodopa-induced dyskinesias (LID) in patients with severe Parkinson disease (PD).
PubMed: 14872017
Links to Exploration step
pubmed:14872017Le document en format XML
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<author><name sortKey="Durif, F" sort="Durif, F" uniqKey="Durif F" first="F" last="Durif">F. Durif</name>
<affiliation><nlm:affiliation>Department of Neurology, Hôpital Gabriel Montpied, Clermont-Ferrand, France. fdurif@chu-clermontferrand.fr</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Debilly, B" sort="Debilly, B" uniqKey="Debilly B" first="B" last="Debilly">B. Debilly</name>
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<author><name sortKey="Galitzky, M" sort="Galitzky, M" uniqKey="Galitzky M" first="M" last="Galitzky">M. Galitzky</name>
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<author><name sortKey="Morand, D" sort="Morand, D" uniqKey="Morand D" first="D" last="Morand">D. Morand</name>
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<author><name sortKey="Viallet, F" sort="Viallet, F" uniqKey="Viallet F" first="F" last="Viallet">F. Viallet</name>
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<author><name sortKey="Borg, M" sort="Borg, M" uniqKey="Borg M" first="M" last="Borg">M. Borg</name>
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<author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S" last="Thobois">S. Thobois</name>
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<author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E" last="Broussolle">E. Broussolle</name>
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<author><name sortKey="Rascol, O" sort="Rascol, O" uniqKey="Rascol O" first="O" last="Rascol">O. Rascol</name>
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<author><name sortKey="Thobois, S" sort="Thobois, S" uniqKey="Thobois S" first="S" last="Thobois">S. Thobois</name>
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<author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E" last="Broussolle">E. Broussolle</name>
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<series><title level="j">Neurology</title>
<idno type="eISSN">1526-632X</idno>
<imprint><date when="2004" type="published">2004</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Antiparkinson Agents (therapeutic use)</term>
<term>Clozapine (therapeutic use)</term>
<term>Double-Blind Method</term>
<term>Dyskinesia, Drug-Induced (drug therapy)</term>
<term>Dyskinesia, Drug-Induced (etiology)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Levodopa (therapeutic use)</term>
<term>Middle Aged</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Serotonin Receptor Agonists (therapeutic use)</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Clozapine</term>
<term>Levodopa</term>
<term>Serotonin Receptor Agonists</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Double-Blind Method</term>
<term>Humans</term>
<term>Middle Aged</term>
<term>Treatment Outcome</term>
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<front><div type="abstract" xml:lang="en">To investigate the efficacy and safety of clozapine in the treatment of levodopa-induced dyskinesias (LID) in patients with severe Parkinson disease (PD).</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14872017</PMID>
<DateCreated><Year>2004</Year>
<Month>02</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2005</Year>
<Month>01</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>62</Volume>
<Issue>3</Issue>
<PubDate><Year>2004</Year>
<Month>Feb</Month>
<Day>10</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
</Journal>
<ArticleTitle>Clozapine improves dyskinesias in Parkinson disease: a double-blind, placebo-controlled study.</ArticleTitle>
<Pagination><MedlinePgn>381-8</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the efficacy and safety of clozapine in the treatment of levodopa-induced dyskinesias (LID) in patients with severe Parkinson disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Fifty patients were randomized to treatment in this 10-week, double-blind, parallel-group, placebo-controlled, multicenter trial. The principal measure of outcome was the diurnal change in the "on" time with LID assessed using a self-evaluation of the motor performance fluctuations performed every 2 weeks. An acute levodopa challenge was also performed at the beginning and end of the study.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">A reduction in the duration of "on" periods with LID was noted in favor of the clozapine group at the end of the study (placebo group day 0: 4.54 +/- 0.53 hours, end: 5.28 +/- 0.70 hours; clozapine group day 0: 5.68 +/- 0.66 hours, end: 3.98 +/- 0.57 hours; p = 0.003). The mean clozapine dosage was 39.4 +/- 4.5 (SEM) mg/day. The maximal LID score at rest during the levodopa challenge was significantly decreased under clozapine treatment, with a variation from day 0 to day 70 in the placebo group of +0.15 +/- 1.01 and in the clozapine group of -2.22 +/- 0.52 (p < 0.05). Five patients receiving clozapine and seven receiving placebo discontinued on account of adverse events. Among them, three patients in the clozapine group developed eosinophilia, which rapidly resolved after withdrawal of the drug.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Clozapine is effective in the treatment of levodopa-induced dyskinesias in severe PD.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Durif</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Hôpital Gabriel Montpied, Clermont-Ferrand, France. fdurif@chu-clermontferrand.fr</Affiliation>
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<Author ValidYN="Y"><LastName>Debilly</LastName>
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<Author ValidYN="Y"><LastName>Galitzky</LastName>
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<Author ValidYN="Y"><LastName>Morand</LastName>
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<MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName>
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<MeshHeading><DescriptorName UI="D003024" MajorTopicYN="N">Clozapine</DescriptorName>
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<MeshHeading><DescriptorName UI="D017366" MajorTopicYN="N">Serotonin Receptor Agonists</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
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