La maladie de Parkinson en France (serveur d'exploration)

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Subthalamic stimulation in Parkinson disease: with or without anesthesia?

Identifieur interne : 001030 ( PubMed/Corpus ); précédent : 001029; suivant : 001031

Subthalamic stimulation in Parkinson disease: with or without anesthesia?

Auteurs : David Maltête ; Soledad Navarro ; Marie-Laure Welter ; Sabine Roche ; Anne-Marie Bonnet ; Jean-Luc Houeto ; Valérie Mesnage ; Bernard Pidoux ; Didier Dormont ; Philippe Cornu ; Yves Agid

Source :

RBID : pubmed:15023817

English descriptors

Abstract

To study the effects of general anesthesia on the postoperative outcome of patients with Parkinson disease (PD) who underwent surgery using bilateral placement of stimulating electrodes within the subthalamic nucleus (STN).

DOI: 10.1001/archneur.61.3.390
PubMed: 15023817

Links to Exploration step

pubmed:15023817

Le document en format XML

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<name sortKey="Navarro, Soledad" sort="Navarro, Soledad" uniqKey="Navarro S" first="Soledad" last="Navarro">Soledad Navarro</name>
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<name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
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<name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
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<name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<name sortKey="Mesnage, Valerie" sort="Mesnage, Valerie" uniqKey="Mesnage V" first="Valérie" last="Mesnage">Valérie Mesnage</name>
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<name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name>
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Case-Control Studies</term>
<term>Disability Evaluation</term>
<term>Dose-Response Relationship, Radiation</term>
<term>Electric Stimulation Therapy (methods)</term>
<term>Electrodes, Implanted</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Activity (physiology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Retrospective Studies</term>
<term>Statistics, Nonparametric</term>
<term>Subthalamic Nucleus (radiation effects)</term>
<term>Time Factors</term>
<term>Treatment Outcome</term>
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<term>Subthalamic Nucleus</term>
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<term>Parkinson Disease</term>
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<term>Case-Control Studies</term>
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<term>Male</term>
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<div type="abstract" xml:lang="en">To study the effects of general anesthesia on the postoperative outcome of patients with Parkinson disease (PD) who underwent surgery using bilateral placement of stimulating electrodes within the subthalamic nucleus (STN).</div>
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<Day>21</Day>
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<Volume>61</Volume>
<Issue>3</Issue>
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<Month>Mar</Month>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To study the effects of general anesthesia on the postoperative outcome of patients with Parkinson disease (PD) who underwent surgery using bilateral placement of stimulating electrodes within the subthalamic nucleus (STN).</AbstractText>
<AbstractText Label="DESIGN" NlmCategory="METHODS">Retrospective analysis.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">Hôpital de la Salpêtrière, Paris, France.</AbstractText>
<AbstractText Label="PATIENTS" NlmCategory="METHODS">Fifteen PD patients who underwent bilateral implantation of electrodes within the STN received general anesthesia because of severe anxiety, poorly tolerated off-period dystonia, or respiratory difficulties. These patients were compared with 15 patients matched for age, disease duration, and parkinsonian motor disability who underwent the same neurosurgical procedure under local anesthesia.</AbstractText>
<AbstractText Label="MAIN OUTCOME MEASURE" NlmCategory="METHODS">Motor disability scores.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">After surgery, the severity of parkinsonian motor disability was markedly improved in both groups of patients. Compared with patients who were under local anesthesia during the operation, the residual parkinsonian motor score under stimulation (with ["on"] or without ["off"] levodopa) and the intensity of stimulation were higher in patients who were under general anesthesia during the operation.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although the improvement of parkinsonian motor disability is greater in PD patients who receive local anesthesia during surgery, general anesthesia can be performed in patients unable to tolerate prolonged states without levodopa.</AbstractText>
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