Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson disease.
Identifieur interne : 001018 ( PubMed/Corpus ); précédent : 001017; suivant : 001019Neurokinin B, neurotensin, and cannabinoid receptor antagonists and Parkinson disease.
Auteurs : V. Mesnage ; J L Houeto ; A M Bonnet ; I. Clavier ; I. Arnulf ; F. Cattelin ; G. Le Fur ; P. Damier ; M L Welter ; Y. AgidSource :
- Clinical neuropharmacology [ 0362-5664 ]
English descriptors
- KwdEn :
- Aged, Antipsychotic Agents (pharmacology), Antipsychotic Agents (therapeutic use), Cannabinoid Receptor Antagonists, Double-Blind Method, Dyskinesia, Drug-Induced (drug therapy), Dyskinesia, Drug-Induced (etiology), Female, Humans, Levodopa, Male, Middle Aged, Movement Disorders (drug therapy), Movement Disorders (etiology), Neurotensin (antagonists & inhibitors), Parkinson Disease (complications), Parkinson Disease (drug therapy), Piperidines (pharmacology), Piperidines (therapeutic use), Pyrazoles (pharmacology), Pyrazoles (therapeutic use), Quinolines (pharmacology), Quinolines (therapeutic use), Receptors, Neurotensin (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Neurotensin, Receptors, Neurotensin.
- chemical , pharmacology : Antipsychotic Agents, Piperidines, Pyrazoles, Quinolines.
- chemical , therapeutic use : Antipsychotic Agents, Piperidines, Pyrazoles, Quinolines.
- complications : Parkinson Disease.
- drug therapy : Dyskinesia, Drug-Induced, Movement Disorders, Parkinson Disease.
- etiology : Dyskinesia, Drug-Induced, Movement Disorders.
- Aged, Cannabinoid Receptor Antagonists, Double-Blind Method, Female, Humans, Levodopa, Male, Middle Aged.
Abstract
The neuropeptides neurokinin B, neurotensin, and anandamide, the endogenous ligands of NK3, NT1, and CB1 receptors respectively, are known to interact with brain dopaminergic transmission. This study evaluated the effects of these three antagonists of the NK3 (SR 142801), neurotensin (SR 48692), and cannabinoid (SR 141716) receptors on the severity of motor symptoms and levodopa-induced dyskinesias after administration of a single dose of levodopa in 24 patients with Parkinson disease. In this exploratory randomized, double-blind, placebo-controlled study, at the dose used, the drugs tested were well tolerated and could not improve parkinsonian motor disability.
PubMed: 15190231
Links to Exploration step
pubmed:15190231Le document en format XML
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<front><div type="abstract" xml:lang="en">The neuropeptides neurokinin B, neurotensin, and anandamide, the endogenous ligands of NK3, NT1, and CB1 receptors respectively, are known to interact with brain dopaminergic transmission. This study evaluated the effects of these three antagonists of the NK3 (SR 142801), neurotensin (SR 48692), and cannabinoid (SR 141716) receptors on the severity of motor symptoms and levodopa-induced dyskinesias after administration of a single dose of levodopa in 24 patients with Parkinson disease. In this exploratory randomized, double-blind, placebo-controlled study, at the dose used, the drugs tested were well tolerated and could not improve parkinsonian motor disability.</div>
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