Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.
Identifieur interne : 001004 ( PubMed/Corpus ); précédent : 001003; suivant : 001005Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.
Auteurs : Pierre Payoux ; Philippe Remy ; Philipe Damier ; Malika Miloudi ; Isabelle Loubinoux ; Bernard Pidoux ; Véronique Gaura ; Olivier Rascol ; Yves Samson ; Yves AgidSource :
- Archives of neurology [ 0003-9942 ] ; 2004.
English descriptors
- KwdEn :
- MESH :
- blood supply : Motor Cortex.
- methods : Electric Stimulation Therapy, Tomography, Emission-Computed.
- physiology : Subthalamic Nucleus.
- physiopathology : Motor Cortex, Parkinson Disease.
- therapy : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Based on the basal ganglia model, it has been hypothesized that the efficacy of high-frequency stimulation of the subthalamic nucleus (STN) against parkinsonian symptoms relies on the activation of cortical premotor regions. In previous positron emission tomography activation studies, STN high-frequency stimulation was associated with selective activation of midline premotor areas during hand movements but mainly reduced the regional cerebral blood flow in movement-related areas, peculiarly at rest.
DOI: 10.1001/archneur.61.8.1307
PubMed: 15313852
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.</title><author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France. payoux.p@chu-toulouse.fr</nlm:affiliation></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author><author><name sortKey="Damier, Philipe" sort="Damier, Philipe" uniqKey="Damier P" first="Philipe" last="Damier">Philipe Damier</name></author><author><name sortKey="Miloudi, Malika" sort="Miloudi, Malika" uniqKey="Miloudi M" first="Malika" last="Miloudi">Malika Miloudi</name></author><author><name sortKey="Loubinoux, Isabelle" sort="Loubinoux, Isabelle" uniqKey="Loubinoux I" first="Isabelle" last="Loubinoux">Isabelle Loubinoux</name></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name></author><author><name sortKey="Gaura, Veronique" sort="Gaura, Veronique" uniqKey="Gaura V" first="Véronique" last="Gaura">Véronique Gaura</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author><author><name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15313852</idno><idno type="pmid">15313852</idno><idno type="doi">10.1001/archneur.61.8.1307</idno><idno type="wicri:Area/PubMed/Corpus">001004</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001004</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.</title><author><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name><affiliation><nlm:affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France. payoux.p@chu-toulouse.fr</nlm:affiliation></affiliation></author><author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Remy">Philippe Remy</name></author><author><name sortKey="Damier, Philipe" sort="Damier, Philipe" uniqKey="Damier P" first="Philipe" last="Damier">Philipe Damier</name></author><author><name sortKey="Miloudi, Malika" sort="Miloudi, Malika" uniqKey="Miloudi M" first="Malika" last="Miloudi">Malika Miloudi</name></author><author><name sortKey="Loubinoux, Isabelle" sort="Loubinoux, Isabelle" uniqKey="Loubinoux I" first="Isabelle" last="Loubinoux">Isabelle Loubinoux</name></author><author><name sortKey="Pidoux, Bernard" sort="Pidoux, Bernard" uniqKey="Pidoux B" first="Bernard" last="Pidoux">Bernard Pidoux</name></author><author><name sortKey="Gaura, Veronique" sort="Gaura, Veronique" uniqKey="Gaura V" first="Véronique" last="Gaura">Véronique Gaura</name></author><author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name></author><author><name sortKey="Samson, Yves" sort="Samson, Yves" uniqKey="Samson Y" first="Yves" last="Samson">Yves Samson</name></author><author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="ISSN">0003-9942</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Electric Stimulation Therapy (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (blood supply)</term><term>Motor Cortex (physiopathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Subthalamic Nucleus (physiology)</term><term>Tomography, Emission-Computed (methods)</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Motor Cortex</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation Therapy</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Based on the basal ganglia model, it has been hypothesized that the efficacy of high-frequency stimulation of the subthalamic nucleus (STN) against parkinsonian symptoms relies on the activation of cortical premotor regions. In previous positron emission tomography activation studies, STN high-frequency stimulation was associated with selective activation of midline premotor areas during hand movements but mainly reduced the regional cerebral blood flow in movement-related areas, peculiarly at rest.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15313852</PMID><DateCreated><Year>2004</Year><Month>08</Month><Day>17</Day></DateCreated><DateCompleted><Year>2004</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0003-9942</ISSN><JournalIssue CitedMedium="Print"><Volume>61</Volume><Issue>8</Issue><PubDate><Year>2004</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Archives of neurology</Title><ISOAbbreviation>Arch. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Subthalamic nucleus stimulation reduces abnormal motor cortical overactivity in Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>1307-13</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Based on the basal ganglia model, it has been hypothesized that the efficacy of high-frequency stimulation of the subthalamic nucleus (STN) against parkinsonian symptoms relies on the activation of cortical premotor regions. In previous positron emission tomography activation studies, STN high-frequency stimulation was associated with selective activation of midline premotor areas during hand movements but mainly reduced the regional cerebral blood flow in movement-related areas, peculiarly at rest.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate with positron emission tomography the role of regional cerebral blood flow reduction in the clinical improvement provided by STN high-frequency stimulation.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Seven patients with advanced Parkinson disease, who were markedly improved by bilateral STN high-frequency stimulation, underwent positron emission tomography with H2(15)O while the right STN electrode was turned off. The patients were studied at rest and during right-hand movements in 3 electrode conditions: no stimulation, inefficient low-frequency stimulation, and efficient high-frequency stimulation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The main effect of high-frequency stimulation was to reduce regional cerebral blood flow in the left primary sensorimotor cortex, the lateral premotor cortex, the right cerebellum, and the midline premotor areas. The selective activation of the anterior cingulate cortex and the left primary sensorimotor cortex during hand movement under STN high-frequency stimulation was attributed to decreased regional cerebral blood flow at rest, rather than increased activation induced by STN high-frequency stimulation. Akinesia was correlated with the abnormal overactivity in the contralateral primary sensorimotor cortex and the ipsilateral cerebellum.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">High-frequency stimulation of the STN acts through the reduction of abnormal resting overactivity in the motor system, allowing selective cortical activation during movement.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Payoux</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale U455, Toulouse, France. payoux.p@chu-toulouse.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Remy</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Damier</LastName><ForeName>Philipe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Miloudi</LastName><ForeName>Malika</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Loubinoux</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Pidoux</LastName><ForeName>Bernard</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Gaura</LastName><ForeName>Véronique</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Rascol</LastName><ForeName>Olivier</ForeName><Initials>O</Initials></Author><Author ValidYN="Y"><LastName>Samson</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Agid</LastName><ForeName>Yves</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Neurol</MedlineTA><NlmUniqueID>0372436</NlmUniqueID><ISSNLinking>0003-9942</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004599" MajorTopicYN="N">Electric Stimulation Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000098" MajorTopicYN="N">blood supply</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020531" MajorTopicYN="N">Subthalamic Nucleus</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014055" MajorTopicYN="N">Tomography, Emission-Computed</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>8</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>9</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>8</Month><Day>18</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15313852</ArticleId><ArticleId IdType="doi">10.1001/archneur.61.8.1307</ArticleId><ArticleId IdType="pii">61/8/1307</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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