Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine.
Identifieur interne : 000F18 ( PubMed/Corpus ); précédent : 000F17; suivant : 000F19Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine.
Auteurs : Frédéric Libert ; François Coudoré ; Damien Richard ; Franck Durif ; Alain EschalierSource :
- Journal of mass spectrometry : JMS [ 1076-5174 ] ; 2005.
English descriptors
- KwdEn :
- Apomorphine (analogs & derivatives), Apomorphine (analysis), Apomorphine (blood), Apomorphine (pharmacokinetics), Apomorphine (urine), Catechol O-Methyltransferase Inhibitors, Catechols (therapeutic use), Gas Chromatography-Mass Spectrometry (methods), Humans, Nitriles, Parkinson Disease (drug therapy), Reproducibility of Results.
- MESH :
- chemical , analogs & derivatives : Apomorphine.
- chemical , analysis : Apomorphine.
- chemical , blood : Apomorphine.
- chemical , pharmacokinetics : Apomorphine.
- chemical , therapeutic use : Catechols.
- chemical , urine : Apomorphine.
- chemical : Catechol O-Methyltransferase Inhibitors, Nitriles.
- drug therapy : Parkinson Disease.
- methods : Gas Chromatography-Mass Spectrometry.
- Humans, Reproducibility of Results.
Abstract
A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. The quantification limits were 1 ng/ml for apomorphine and apocodeine and 25 ng/ml for norapomorphine. Calibration curves were linear, within the range 1-100 ng/ml. Variation in intraday and interday precision was below 10%. This method was applied to study apomorphine bioavailability in nine patients with Parkinson's disease before and after coadministration of a catechol-O-methyl transferase inhibitor.
DOI: 10.1002/jms.939
PubMed: 16285020
Links to Exploration step
pubmed:16285020Le document en format XML
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<author><name sortKey="Libert, Frederic" sort="Libert, Frederic" uniqKey="Libert F" first="Frédéric" last="Libert">Frédéric Libert</name>
<affiliation><nlm:affiliation>Pharmacology and Toxicology Laboratory, CHU G. Montpied, Clermont-Ferrand, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Coudore, Francois" sort="Coudore, Francois" uniqKey="Coudore F" first="François" last="Coudoré">François Coudoré</name>
</author>
<author><name sortKey="Richard, Damien" sort="Richard, Damien" uniqKey="Richard D" first="Damien" last="Richard">Damien Richard</name>
</author>
<author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
</author>
<author><name sortKey="Eschalier, Alain" sort="Eschalier, Alain" uniqKey="Eschalier A" first="Alain" last="Eschalier">Alain Eschalier</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine.</title>
<author><name sortKey="Libert, Frederic" sort="Libert, Frederic" uniqKey="Libert F" first="Frédéric" last="Libert">Frédéric Libert</name>
<affiliation><nlm:affiliation>Pharmacology and Toxicology Laboratory, CHU G. Montpied, Clermont-Ferrand, France.</nlm:affiliation>
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<author><name sortKey="Coudore, Francois" sort="Coudore, Francois" uniqKey="Coudore F" first="François" last="Coudoré">François Coudoré</name>
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<author><name sortKey="Richard, Damien" sort="Richard, Damien" uniqKey="Richard D" first="Damien" last="Richard">Damien Richard</name>
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<author><name sortKey="Durif, Franck" sort="Durif, Franck" uniqKey="Durif F" first="Franck" last="Durif">Franck Durif</name>
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<author><name sortKey="Eschalier, Alain" sort="Eschalier, Alain" uniqKey="Eschalier A" first="Alain" last="Eschalier">Alain Eschalier</name>
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<series><title level="j">Journal of mass spectrometry : JMS</title>
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<imprint><date when="2005" type="published">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apomorphine (analogs & derivatives)</term>
<term>Apomorphine (analysis)</term>
<term>Apomorphine (blood)</term>
<term>Apomorphine (pharmacokinetics)</term>
<term>Apomorphine (urine)</term>
<term>Catechol O-Methyltransferase Inhibitors</term>
<term>Catechols (therapeutic use)</term>
<term>Gas Chromatography-Mass Spectrometry (methods)</term>
<term>Humans</term>
<term>Nitriles</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Apomorphine</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Apomorphine</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Apomorphine</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Catechols</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="urine" xml:lang="en"><term>Apomorphine</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Catechol O-Methyltransferase Inhibitors</term>
<term>Nitriles</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Gas Chromatography-Mass Spectrometry</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>Reproducibility of Results</term>
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<front><div type="abstract" xml:lang="en">A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. The quantification limits were 1 ng/ml for apomorphine and apocodeine and 25 ng/ml for norapomorphine. Calibration curves were linear, within the range 1-100 ng/ml. Variation in intraday and interday precision was below 10%. This method was applied to study apomorphine bioavailability in nine patients with Parkinson's disease before and after coadministration of a catechol-O-methyl transferase inhibitor.</div>
</front>
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<DateCreated><Year>2005</Year>
<Month>12</Month>
<Day>06</Day>
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<DateCompleted><Year>2006</Year>
<Month>02</Month>
<Day>09</Day>
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<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">1076-5174</ISSN>
<JournalIssue CitedMedium="Print"><Volume>40</Volume>
<Issue>12</Issue>
<PubDate><Year>2005</Year>
<Month>Dec</Month>
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<Title>Journal of mass spectrometry : JMS</Title>
<ISOAbbreviation>J Mass Spectrom</ISOAbbreviation>
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<ArticleTitle>Development of a gas chromatographic/mass spectrometric method to quantify R(-)-apomorphine, R(-)-apocodeine and R(-)-norapomorphine in human plasma and urine.</ArticleTitle>
<Pagination><MedlinePgn>1521-5</MedlinePgn>
</Pagination>
<Abstract><AbstractText>A method was developed and validated for the analysis of R(-)-apomorphine, (R-)-apocodeine and R(-)-norapomorphine in human plasma and urine with N-propylnorapomorphine as internal standard using gas chromatography/mass spectrometry (GC/MS) and single-ion monitoring after a single liquid-liquid extraction and silylation of compounds. The quantification limits were 1 ng/ml for apomorphine and apocodeine and 25 ng/ml for norapomorphine. Calibration curves were linear, within the range 1-100 ng/ml. Variation in intraday and interday precision was below 10%. This method was applied to study apomorphine bioavailability in nine patients with Parkinson's disease before and after coadministration of a catechol-O-methyl transferase inhibitor.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Libert</LastName>
<ForeName>Frédéric</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Pharmacology and Toxicology Laboratory, CHU G. Montpied, Clermont-Ferrand, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Coudoré</LastName>
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<Initials>F</Initials>
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<Author ValidYN="Y"><LastName>Richard</LastName>
<ForeName>Damien</ForeName>
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<Author ValidYN="Y"><LastName>Durif</LastName>
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<Author ValidYN="Y"><LastName>Eschalier</LastName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>J Mass Spectrom</MedlineTA>
<NlmUniqueID>9504818</NlmUniqueID>
<ISSNLinking>1076-5174</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D065098">Catechol O-Methyltransferase Inhibitors</NameOfSubstance>
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<NameOfSubstance UI="D002396">Catechols</NameOfSubstance>
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<Chemical><RegistryNumber>478-76-2</RegistryNumber>
<NameOfSubstance UI="C008668">norapomorphine</NameOfSubstance>
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<Chemical><RegistryNumber>4975G9NM6T</RegistryNumber>
<NameOfSubstance UI="C071192">entacapone</NameOfSubstance>
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<Chemical><RegistryNumber>N21FAR7B4S</RegistryNumber>
<NameOfSubstance UI="D001058">Apomorphine</NameOfSubstance>
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<Chemical><RegistryNumber>OBF8X37Y5W</RegistryNumber>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D001058" MajorTopicYN="N">Apomorphine</DescriptorName>
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<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000652" MajorTopicYN="N">urine</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065098" MajorTopicYN="N">Catechol O-Methyltransferase Inhibitors</DescriptorName>
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<MeshHeading><DescriptorName UI="D002396" MajorTopicYN="N">Catechols</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D008401" MajorTopicYN="N">Gas Chromatography-Mass Spectrometry</DescriptorName>
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<MeshHeading><DescriptorName UI="D009570" MajorTopicYN="N">Nitriles</DescriptorName>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
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<MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName>
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