ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000E47

"Paradoxical kinesis" is not a hallmark of Parkinson's disease but a general property of the motor system.

Identifieur interne : 000E47 ( PubMed/Corpus ); précédent : 000E46; suivant : 000E48

"Paradoxical kinesis" is not a hallmark of Parkinson's disease but a general property of the motor system.

Auteurs : Bénédicte Ballanger ; Stéphane Thobois ; Pierre Baraduc ; Robert S. Turner ; Emmanuel Broussolle ; Michel Desmurget

Source :

Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2006.

RBID : pubmed:16758482

English descriptors

KwdEn :
- Aged, Arousal (physiology), Cues, Dominance, Cerebral (physiology), Female, Humans, Hypokinesia (diagnosis), Hypokinesia (physiopathology), Male, Middle Aged, Motion Perception (physiology), Motivation, Motor Activity (physiology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Psychomotor Performance (physiology), Reaction Time (physiology).
MESH :
- diagnosis : Hypokinesia, Parkinson Disease.
- physiology : Arousal, Dominance, Cerebral, Motion Perception, Motor Activity, Psychomotor Performance, Reaction Time.
- physiopathology : Hypokinesia, Parkinson Disease.
- Aged, Cues, Female, Humans, Male, Middle Aged, Motivation.

Abstract

Although slowness of movement is a typical feature of Parkinson's disease (PD), it has been suggested that severely disabled patients remained able to produce normal motor responses in the context of urgent or externally driven situations. To investigate this phenomenon (often designated "paradoxical kinesis"), we required PD patients and healthy subjects to press a large switch under three main conditions: Self Generated, produce the fastest possible movement; External Cue, same as Self Generated but in response to an acoustic cue; Urgent External Cue, same as External Cue with the switch controlling an electromagnet that prevented a ball falling at the bottom of a tilted ramp. Task difficulty was equalized for the two experimental groups. Results showed that external cues and urgent conditions decreased movement duration (Urgent External Cue < External Cue < Self Generated) and reaction time (Urgent External Cue < External Cue). The amount of reduction was identical in PD patients and healthy subjects. These observations show that paradoxical kineses are not a hallmark of PD or a byproduct of basal ganglia dysfunctions, but a general property of the motor system.

DOI: 10.1002/mds.20987
PubMed: 16758482

Links to Exploration step

pubmed:16758482

Le document en format XML

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<author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Bénédicte" last="Ballanger">Bénédicte Ballanger</name>
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<author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name>
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<author><name sortKey="Baraduc, Pierre" sort="Baraduc, Pierre" uniqKey="Baraduc P" first="Pierre" last="Baraduc">Pierre Baraduc</name>
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<author><name sortKey="Turner, Robert S" sort="Turner, Robert S" uniqKey="Turner R" first="Robert S" last="Turner">Robert S. Turner</name>
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<author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name>
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<author><name sortKey="Desmurget, Michel" sort="Desmurget, Michel" uniqKey="Desmurget M" first="Michel" last="Desmurget">Michel Desmurget</name>
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<term>Motor Activity</term>
<term>Psychomotor Performance</term>
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<front><div type="abstract" xml:lang="en">Although slowness of movement is a typical feature of Parkinson's disease (PD), it has been suggested that severely disabled patients remained able to produce normal motor responses in the context of urgent or externally driven situations. To investigate this phenomenon (often designated "paradoxical kinesis"), we required PD patients and healthy subjects to press a large switch under three main conditions: Self Generated, produce the fastest possible movement; External Cue, same as Self Generated but in response to an acoustic cue; Urgent External Cue, same as External Cue with the switch controlling an electromagnet that prevented a ball falling at the bottom of a tilted ramp. Task difficulty was equalized for the two experimental groups. Results showed that external cues and urgent conditions decreased movement duration (Urgent External Cue < External Cue < Self Generated) and reaction time (Urgent External Cue < External Cue). The amount of reduction was identical in PD patients and healthy subjects. These observations show that paradoxical kineses are not a hallmark of PD or a byproduct of basal ganglia dysfunctions, but a general property of the motor system.</div>
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<Abstract><AbstractText>Although slowness of movement is a typical feature of Parkinson's disease (PD), it has been suggested that severely disabled patients remained able to produce normal motor responses in the context of urgent or externally driven situations. To investigate this phenomenon (often designated "paradoxical kinesis"), we required PD patients and healthy subjects to press a large switch under three main conditions: Self Generated, produce the fastest possible movement; External Cue, same as Self Generated but in response to an acoustic cue; Urgent External Cue, same as External Cue with the switch controlling an electromagnet that prevented a ball falling at the bottom of a tilted ramp. Task difficulty was equalized for the two experimental groups. Results showed that external cues and urgent conditions decreased movement duration (Urgent External Cue < External Cue < Self Generated) and reaction time (Urgent External Cue < External Cue). The amount of reduction was identical in PD patients and healthy subjects. These observations show that paradoxical kineses are not a hallmark of PD or a byproduct of basal ganglia dysfunctions, but a general property of the motor system.</AbstractText>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

"Paradoxical kinesis" is not a hallmark of Parkinson's disease but a general property of the motor system.

"Paradoxical kinesis" is not a hallmark of Parkinson's disease but a general property of the motor system.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki