Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns.
Identifieur interne : 000D19 ( PubMed/Corpus ); précédent : 000D18; suivant : 000D20Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns.
Auteurs : Véronique Boulenger ; Laura Mechtouff ; Stéphane Thobois ; Emmanuel Broussolle ; Marc Jeannerod ; Tatjana A. NazirSource :
- Neuropsychologia [ 0028-3932 ] ; 2008.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Antiparkinson Agents (therapeutic use), Case-Control Studies, Cues, Female, Humans, Language Disorders (complications), Language Disorders (diagnosis), Language Disorders (drug therapy), Levodopa (therapeutic use), Male, Middle Aged, Motor Cortex (drug effects), Motor Cortex (physiology), Motor Cortex (physiopathology), Motor Skills, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Reaction Time (drug effects), Reaction Time (physiology), Reference Values, Semantics, Terminology as Topic.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- complications : Language Disorders, Parkinson Disease.
- diagnosis : Language Disorders.
- drug effects : Motor Cortex, Reaction Time.
- drug therapy : Language Disorders, Parkinson Disease.
- physiology : Motor Cortex, Reaction Time.
- physiopathology : Motor Cortex, Parkinson Disease.
- Aged, Analysis of Variance, Case-Control Studies, Cues, Female, Humans, Male, Middle Aged, Motor Skills, Reference Values, Semantics, Terminology as Topic.
Abstract
Recent studies have demonstrated that processing of action words recruits cortical motor regions that are also involved in the planning and execution of the actions words refer to. The functional role of these regions in word understanding remains, however, to be clarified. The present study investigates this issue by examining the impact of Parkinson's disease (PD) on lexical decision performance for action words, relative to concrete nouns, in a masked priming paradigm. Priming effects for the two word categories were measured in non-demented PD patients off and on dopaminergic treatment, and in healthy participants. Our results revealed that although overall performances did not differ between verbs and nouns, priming effects showed a clear dissociation between word categories. While priming for concrete nouns was not affected by Levodopa intake, it dissociated as a function of treatment for action verbs. No priming was actually obtained for action verbs in PD patients off dopaminergic treatment. Following Levodopa intake, this deficit recovered, however, because priming effects for verbs became comparable to those for concrete nouns and similar to performance of healthy participants. Overall, this study thus brings compelling evidence that processing lexico-semantic information about action words depends on the integrity of the motor system.
DOI: 10.1016/j.neuropsychologia.2007.10.007
PubMed: 18037143
Links to Exploration step
pubmed:18037143Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns.</title><author><name sortKey="Boulenger, Veronique" sort="Boulenger, Veronique" uniqKey="Boulenger V" first="Véronique" last="Boulenger">Véronique Boulenger</name><affiliation><nlm:affiliation>L2C2-Institut des Sciences Cognitives, UMR 5230 CNRS/Université Claude Bernard Lyon I, 67 boulevard Pinel, 69675 Bron Cedex, France. boulenger@isc.cnrs.fr</nlm:affiliation></affiliation></author><author><name sortKey="Mechtouff, Laura" sort="Mechtouff, Laura" uniqKey="Mechtouff L" first="Laura" last="Mechtouff">Laura Mechtouff</name></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Jeannerod, Marc" sort="Jeannerod, Marc" uniqKey="Jeannerod M" first="Marc" last="Jeannerod">Marc Jeannerod</name></author><author><name sortKey="Nazir, Tatjana A" sort="Nazir, Tatjana A" uniqKey="Nazir T" first="Tatjana A" last="Nazir">Tatjana A. Nazir</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18037143</idno><idno type="pmid">18037143</idno><idno type="doi">10.1016/j.neuropsychologia.2007.10.007</idno><idno type="wicri:Area/PubMed/Corpus">000D19</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns.</title><author><name sortKey="Boulenger, Veronique" sort="Boulenger, Veronique" uniqKey="Boulenger V" first="Véronique" last="Boulenger">Véronique Boulenger</name><affiliation><nlm:affiliation>L2C2-Institut des Sciences Cognitives, UMR 5230 CNRS/Université Claude Bernard Lyon I, 67 boulevard Pinel, 69675 Bron Cedex, France. boulenger@isc.cnrs.fr</nlm:affiliation></affiliation></author><author><name sortKey="Mechtouff, Laura" sort="Mechtouff, Laura" uniqKey="Mechtouff L" first="Laura" last="Mechtouff">Laura Mechtouff</name></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Jeannerod, Marc" sort="Jeannerod, Marc" uniqKey="Jeannerod M" first="Marc" last="Jeannerod">Marc Jeannerod</name></author><author><name sortKey="Nazir, Tatjana A" sort="Nazir, Tatjana A" uniqKey="Nazir T" first="Tatjana A" last="Nazir">Tatjana A. Nazir</name></author></analytic><series><title level="j">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Antiparkinson Agents (therapeutic use)</term><term>Case-Control Studies</term><term>Cues</term><term>Female</term><term>Humans</term><term>Language Disorders (complications)</term><term>Language Disorders (diagnosis)</term><term>Language Disorders (drug therapy)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (drug effects)</term><term>Motor Cortex (physiology)</term><term>Motor Cortex (physiopathology)</term><term>Motor Skills</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Reaction Time (drug effects)</term><term>Reaction Time (physiology)</term><term>Reference Values</term><term>Semantics</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Language Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Language Disorders</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Cortex</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Language Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Motor Cortex</term><term>Reaction Time</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Motor Cortex</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Analysis of Variance</term><term>Case-Control Studies</term><term>Cues</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motor Skills</term><term>Reference Values</term><term>Semantics</term><term>Terminology as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have demonstrated that processing of action words recruits cortical motor regions that are also involved in the planning and execution of the actions words refer to. The functional role of these regions in word understanding remains, however, to be clarified. The present study investigates this issue by examining the impact of Parkinson's disease (PD) on lexical decision performance for action words, relative to concrete nouns, in a masked priming paradigm. Priming effects for the two word categories were measured in non-demented PD patients off and on dopaminergic treatment, and in healthy participants. Our results revealed that although overall performances did not differ between verbs and nouns, priming effects showed a clear dissociation between word categories. While priming for concrete nouns was not affected by Levodopa intake, it dissociated as a function of treatment for action verbs. No priming was actually obtained for action verbs in PD patients off dopaminergic treatment. Following Levodopa intake, this deficit recovered, however, because priming effects for verbs became comparable to those for concrete nouns and similar to performance of healthy participants. Overall, this study thus brings compelling evidence that processing lexico-semantic information about action words depends on the integrity of the motor system.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18037143</PMID><DateCreated><Year>2008</Year><Month>02</Month><Day>11</Day></DateCreated><DateCompleted><Year>2008</Year><Month>05</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0028-3932</ISSN><JournalIssue CitedMedium="Print"><Volume>46</Volume><Issue>2</Issue><PubDate><Year>2008</Year><Month>Jan</Month><Day>31</Day></PubDate></JournalIssue><Title>Neuropsychologia</Title><ISOAbbreviation>Neuropsychologia</ISOAbbreviation></Journal><ArticleTitle>Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns.</ArticleTitle><Pagination><MedlinePgn>743-56</MedlinePgn></Pagination><Abstract><AbstractText>Recent studies have demonstrated that processing of action words recruits cortical motor regions that are also involved in the planning and execution of the actions words refer to. The functional role of these regions in word understanding remains, however, to be clarified. The present study investigates this issue by examining the impact of Parkinson's disease (PD) on lexical decision performance for action words, relative to concrete nouns, in a masked priming paradigm. Priming effects for the two word categories were measured in non-demented PD patients off and on dopaminergic treatment, and in healthy participants. Our results revealed that although overall performances did not differ between verbs and nouns, priming effects showed a clear dissociation between word categories. While priming for concrete nouns was not affected by Levodopa intake, it dissociated as a function of treatment for action verbs. No priming was actually obtained for action verbs in PD patients off dopaminergic treatment. Following Levodopa intake, this deficit recovered, however, because priming effects for verbs became comparable to those for concrete nouns and similar to performance of healthy participants. Overall, this study thus brings compelling evidence that processing lexico-semantic information about action words depends on the integrity of the motor system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Boulenger</LastName><ForeName>Véronique</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>L2C2-Institut des Sciences Cognitives, UMR 5230 CNRS/Université Claude Bernard Lyon I, 67 boulevard Pinel, 69675 Bron Cedex, France. boulenger@isc.cnrs.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mechtouff</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Thobois</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Broussolle</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Jeannerod</LastName><ForeName>Marc</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Nazir</LastName><ForeName>Tatjana A</ForeName><Initials>TA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>10</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Neuropsychologia</MedlineTA><NlmUniqueID>0020713</NlmUniqueID><ISSNLinking>0028-3932</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003463" MajorTopicYN="N">Cues</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007806" MajorTopicYN="N">Language Disorders</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009048" MajorTopicYN="Y">Motor Skills</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011930" MajorTopicYN="N">Reaction Time</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012016" MajorTopicYN="N">Reference Values</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012660" MajorTopicYN="Y">Semantics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009626" MajorTopicYN="N">Terminology as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>05</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2007</Year><Month>09</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>11</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>5</Month><Day>3</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>11</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18037143</ArticleId><ArticleId IdType="pii">S0028-3932(07)00357-0</ArticleId><ArticleId IdType="doi">10.1016/j.neuropsychologia.2007.10.007</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D19 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000D19 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:18037143
|texte= Word processing in Parkinson's disease is impaired for action verbs but not for concrete nouns.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:18037143" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |