Disconnecting force from money: effects of basal ganglia damage on incentive motivation.
Identifieur interne : 000C94 ( PubMed/Corpus ); précédent : 000C93; suivant : 000C95Disconnecting force from money: effects of basal ganglia damage on incentive motivation.
Auteurs : Liane Schmidt ; Baudouin Forgeot D'Arc ; Gilles Lafargue ; Damien Galanaud ; Virginie Czernecki ; David Grabli ; Michael Schüpbach ; Andreas Hartmann ; Richard Lévy ; Bruno Dubois ; Mathias PessiglioneSource :
- Brain : a journal of neurology [ 1460-2156 ] ; 2008.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Basal Ganglia (physiopathology), Basal Ganglia Diseases (pathology), Basal Ganglia Diseases (physiopathology), Basal Ganglia Diseases (psychology), Brain Mapping (methods), Female, Galvanic Skin Response, Hand Strength, Humans, Magnetic Resonance Imaging (methods), Male, Middle Aged, Motivation, Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (psychology), Psychomotor Disorders (etiology), Psychomotor Disorders (pathology), Psychomotor Disorders (physiopathology), Psychomotor Performance, Reward, Severity of Illness Index.
- MESH :
- etiology : Psychomotor Disorders.
- methods : Brain Mapping, Magnetic Resonance Imaging.
- pathology : Basal Ganglia Diseases, Parkinson Disease, Psychomotor Disorders.
- physiopathology : Basal Ganglia, Basal Ganglia Diseases, Parkinson Disease, Psychomotor Disorders.
- psychology : Basal Ganglia Diseases, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Female, Galvanic Skin Response, Hand Strength, Humans, Male, Middle Aged, Motivation, Psychomotor Performance, Reward, Severity of Illness Index.
Abstract
Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation. We hypothesized that AAD reflects a dysfunction of incentive motivation, a process that translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed a behavioural paradigm contrasting an instructed (externally driven) task, in which subjects have to produce different levels of force by squeezing a hand grip, to an incentive (self-driven) task, in which subjects can win, depending on their hand grip force, different amounts of money. Skin conductance was simultaneously measured to index affective evaluation of monetary incentives. Thirteen AAD patients with bilateral striato-pallidal lesions were compared to thirteen unmedicated patients with Parkinson's; disease (PD), which is characterized by striatal dopamine depletion and regularly associated with apathy. AAD patients did not differ from PD patients in terms of grip force response to external instructions or skin conductance response to monetary incentives. However, unlike PD patients, they failed to distinguish between monetary incentives in their grip force. We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards.
DOI: 10.1093/brain/awn045
PubMed: 18344560
Links to Exploration step
pubmed:18344560Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Disconnecting force from money: effects of basal ganglia damage on incentive motivation.</title><author><name sortKey="Schmidt, Liane" sort="Schmidt, Liane" uniqKey="Schmidt L" first="Liane" last="Schmidt">Liane Schmidt</name><affiliation><nlm:affiliation>Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Université Pierre et Marie Curie (Paris 6), Site Pitié-Salpêtrière, F-75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="D Arc, Baudouin Forgeot" sort="D Arc, Baudouin Forgeot" uniqKey="D Arc B" first="Baudouin Forgeot" last="D'Arc">Baudouin Forgeot D'Arc</name></author><author><name sortKey="Lafargue, Gilles" sort="Lafargue, Gilles" uniqKey="Lafargue G" first="Gilles" last="Lafargue">Gilles Lafargue</name></author><author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name></author><author><name sortKey="Czernecki, Virginie" sort="Czernecki, Virginie" uniqKey="Czernecki V" first="Virginie" last="Czernecki">Virginie Czernecki</name></author><author><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name></author><author><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name></author><author><name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name></author><author><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Lévy">Richard Lévy</name></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></author><author><name sortKey="Pessiglione, Mathias" sort="Pessiglione, Mathias" uniqKey="Pessiglione M" first="Mathias" last="Pessiglione">Mathias Pessiglione</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18344560</idno><idno type="pmid">18344560</idno><idno type="doi">10.1093/brain/awn045</idno><idno type="wicri:Area/PubMed/Corpus">000C94</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Disconnecting force from money: effects of basal ganglia damage on incentive motivation.</title><author><name sortKey="Schmidt, Liane" sort="Schmidt, Liane" uniqKey="Schmidt L" first="Liane" last="Schmidt">Liane Schmidt</name><affiliation><nlm:affiliation>Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Université Pierre et Marie Curie (Paris 6), Site Pitié-Salpêtrière, F-75013 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="D Arc, Baudouin Forgeot" sort="D Arc, Baudouin Forgeot" uniqKey="D Arc B" first="Baudouin Forgeot" last="D'Arc">Baudouin Forgeot D'Arc</name></author><author><name sortKey="Lafargue, Gilles" sort="Lafargue, Gilles" uniqKey="Lafargue G" first="Gilles" last="Lafargue">Gilles Lafargue</name></author><author><name sortKey="Galanaud, Damien" sort="Galanaud, Damien" uniqKey="Galanaud D" first="Damien" last="Galanaud">Damien Galanaud</name></author><author><name sortKey="Czernecki, Virginie" sort="Czernecki, Virginie" uniqKey="Czernecki V" first="Virginie" last="Czernecki">Virginie Czernecki</name></author><author><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name></author><author><name sortKey="Schupbach, Michael" sort="Schupbach, Michael" uniqKey="Schupbach M" first="Michael" last="Schüpbach">Michael Schüpbach</name></author><author><name sortKey="Hartmann, Andreas" sort="Hartmann, Andreas" uniqKey="Hartmann A" first="Andreas" last="Hartmann">Andreas Hartmann</name></author><author><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Lévy">Richard Lévy</name></author><author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name></author><author><name sortKey="Pessiglione, Mathias" sort="Pessiglione, Mathias" uniqKey="Pessiglione M" first="Mathias" last="Pessiglione">Mathias Pessiglione</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="eISSN">1460-2156</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Basal Ganglia (physiopathology)</term><term>Basal Ganglia Diseases (pathology)</term><term>Basal Ganglia Diseases (physiopathology)</term><term>Basal Ganglia Diseases (psychology)</term><term>Brain Mapping (methods)</term><term>Female</term><term>Galvanic Skin Response</term><term>Hand Strength</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Motivation</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Psychomotor Disorders (etiology)</term><term>Psychomotor Disorders (pathology)</term><term>Psychomotor Disorders (physiopathology)</term><term>Psychomotor Performance</term><term>Reward</term><term>Severity of Illness Index</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Brain Mapping</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Parkinson Disease</term><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Basal Ganglia Diseases</term><term>Parkinson Disease</term><term>Psychomotor Disorders</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Galvanic Skin Response</term><term>Hand Strength</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Motivation</term><term>Psychomotor Performance</term><term>Reward</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation. We hypothesized that AAD reflects a dysfunction of incentive motivation, a process that translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed a behavioural paradigm contrasting an instructed (externally driven) task, in which subjects have to produce different levels of force by squeezing a hand grip, to an incentive (self-driven) task, in which subjects can win, depending on their hand grip force, different amounts of money. Skin conductance was simultaneously measured to index affective evaluation of monetary incentives. Thirteen AAD patients with bilateral striato-pallidal lesions were compared to thirteen unmedicated patients with Parkinson's; disease (PD), which is characterized by striatal dopamine depletion and regularly associated with apathy. AAD patients did not differ from PD patients in terms of grip force response to external instructions or skin conductance response to monetary incentives. However, unlike PD patients, they failed to distinguish between monetary incentives in their grip force. We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18344560</PMID><DateCreated><Year>2008</Year><Month>05</Month><Day>02</Day></DateCreated><DateCompleted><Year>2008</Year><Month>06</Month><Day>16</Day></DateCompleted><DateRevised><Year>2014</Year><Month>03</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2156</ISSN><JournalIssue CitedMedium="Internet"><Volume>131</Volume><Issue>Pt 5</Issue><PubDate><Year>2008</Year><Month>May</Month></PubDate></JournalIssue><Title>Brain : a journal of neurology</Title><ISOAbbreviation>Brain</ISOAbbreviation></Journal><ArticleTitle>Disconnecting force from money: effects of basal ganglia damage on incentive motivation.</ArticleTitle><Pagination><MedlinePgn>1303-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/brain/awn045</ELocationID><Abstract><AbstractText>Bilateral basal ganglia lesions have been reported to induce a particular form of apathy, termed auto-activation deficit (AAD), principally defined as a loss of self-driven behaviour that is reversible with external stimulation. We hypothesized that AAD reflects a dysfunction of incentive motivation, a process that translates an expected reward (or goal) into behavioural activation. To investigate this hypothesis, we designed a behavioural paradigm contrasting an instructed (externally driven) task, in which subjects have to produce different levels of force by squeezing a hand grip, to an incentive (self-driven) task, in which subjects can win, depending on their hand grip force, different amounts of money. Skin conductance was simultaneously measured to index affective evaluation of monetary incentives. Thirteen AAD patients with bilateral striato-pallidal lesions were compared to thirteen unmedicated patients with Parkinson's; disease (PD), which is characterized by striatal dopamine depletion and regularly associated with apathy. AAD patients did not differ from PD patients in terms of grip force response to external instructions or skin conductance response to monetary incentives. However, unlike PD patients, they failed to distinguish between monetary incentives in their grip force. We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Liane</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Université Pierre et Marie Curie (Paris 6), Site Pitié-Salpêtrière, F-75013 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>d'Arc</LastName><ForeName>Baudouin Forgeot</ForeName><Initials>BF</Initials></Author><Author ValidYN="Y"><LastName>Lafargue</LastName><ForeName>Gilles</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Galanaud</LastName><ForeName>Damien</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Czernecki</LastName><ForeName>Virginie</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Grabli</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Schüpbach</LastName><ForeName>Michael</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hartmann</LastName><ForeName>Andreas</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Lévy</LastName><ForeName>Richard</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Dubois</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Pessiglione</LastName><ForeName>Mathias</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>03</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Brain</MedlineTA><NlmUniqueID>0372537</NlmUniqueID><ISSNLinking>0006-8950</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001479" MajorTopicYN="N">Basal Ganglia</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001480" MajorTopicYN="N">Basal Ganglia Diseases</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001931" MajorTopicYN="N">Brain Mapping</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005712" MajorTopicYN="N">Galvanic Skin Response</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018737" MajorTopicYN="N">Hand Strength</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009042" MajorTopicYN="Y">Motivation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011596" MajorTopicYN="N">Psychomotor Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011597" MajorTopicYN="N">Psychomotor Performance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012201" MajorTopicYN="Y">Reward</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2008</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>6</Month><Day>17</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2008</Year><Month>3</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">18344560</ArticleId><ArticleId IdType="pii">awn045</ArticleId><ArticleId IdType="doi">10.1093/brain/awn045</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000C94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:18344560
|texte= Disconnecting force from money: effects of basal ganglia damage on incentive motivation.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:18344560" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |