Working memory in Parkinson's disease patients: clinical features and response to levodopa.
Identifieur interne : 000C87 ( PubMed/Corpus ); précédent : 000C86; suivant : 000C88Working memory in Parkinson's disease patients: clinical features and response to levodopa.
Auteurs : Rogério Beato ; Richard Levy ; Bernard Pillon ; Christine Vidal ; Sophie Tezenas Du Montcel ; Bernard Deweer ; Anne-Marie Bonnet ; Jean-Luc Houeto ; Bruno Dubois ; Francisco CardosoSource :
- Arquivos de neuro-psiquiatria [ 0004-282X ] ; 2008.
English descriptors
- KwdEn :
- Aged, Analysis of Variance, Antiparkinson Agents (therapeutic use), Case-Control Studies, Dopamine Agents (therapeutic use), Female, Humans, Levodopa (therapeutic use), Male, Memory (drug effects), Memory (physiology), Memory, Short-Term (drug effects), Middle Aged, Neuropsychological Tests, Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Space Perception (drug effects), Space Perception (physiology).
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Dopamine Agents, Levodopa.
- drug effects : Memory, Memory, Short-Term, Space Perception.
- drug therapy : Parkinson Disease.
- physiology : Memory, Space Perception.
- physiopathology : Parkinson Disease.
- Aged, Analysis of Variance, Case-Control Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM.
PubMed: 18545772
Links to Exploration step
pubmed:18545772Le document en format XML
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<author><name sortKey="Beato, Rogerio" sort="Beato, Rogerio" uniqKey="Beato R" first="Rogério" last="Beato">Rogério Beato</name>
<affiliation><nlm:affiliation>INSERM U610, Groupe Hospitalier de la Pitié-Salpêtrière, Paris, France.</nlm:affiliation>
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<author><name sortKey="Levy, Richard" sort="Levy, Richard" uniqKey="Levy R" first="Richard" last="Levy">Richard Levy</name>
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<author><name sortKey="Pillon, Bernard" sort="Pillon, Bernard" uniqKey="Pillon B" first="Bernard" last="Pillon">Bernard Pillon</name>
</author>
<author><name sortKey="Vidal, Christine" sort="Vidal, Christine" uniqKey="Vidal C" first="Christine" last="Vidal">Christine Vidal</name>
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<author><name sortKey="Du Montcel, Sophie Tezenas" sort="Du Montcel, Sophie Tezenas" uniqKey="Du Montcel S" first="Sophie Tezenas" last="Du Montcel">Sophie Tezenas Du Montcel</name>
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<author><name sortKey="Deweer, Bernard" sort="Deweer, Bernard" uniqKey="Deweer B" first="Bernard" last="Deweer">Bernard Deweer</name>
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<author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
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<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
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<author><name sortKey="Cardoso, Francisco" sort="Cardoso, Francisco" uniqKey="Cardoso F" first="Francisco" last="Cardoso">Francisco Cardoso</name>
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<author><name sortKey="Vidal, Christine" sort="Vidal, Christine" uniqKey="Vidal C" first="Christine" last="Vidal">Christine Vidal</name>
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<author><name sortKey="Du Montcel, Sophie Tezenas" sort="Du Montcel, Sophie Tezenas" uniqKey="Du Montcel S" first="Sophie Tezenas" last="Du Montcel">Sophie Tezenas Du Montcel</name>
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<author><name sortKey="Bonnet, Anne Marie" sort="Bonnet, Anne Marie" uniqKey="Bonnet A" first="Anne-Marie" last="Bonnet">Anne-Marie Bonnet</name>
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<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
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<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
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<series><title level="j">Arquivos de neuro-psiquiatria</title>
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<term>Antiparkinson Agents (therapeutic use)</term>
<term>Case-Control Studies</term>
<term>Dopamine Agents (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (therapeutic use)</term>
<term>Male</term>
<term>Memory (drug effects)</term>
<term>Memory (physiology)</term>
<term>Memory, Short-Term (drug effects)</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Space Perception (drug effects)</term>
<term>Space Perception (physiology)</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Dopamine Agents</term>
<term>Levodopa</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Memory</term>
<term>Memory, Short-Term</term>
<term>Space Perception</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<term>Space Perception</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18545772</PMID>
<DateCreated><Year>2008</Year>
<Month>06</Month>
<Day>11</Day>
</DateCreated>
<DateCompleted><Year>2008</Year>
<Month>11</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0004-282X</ISSN>
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<Issue>2A</Issue>
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<Month>Jun</Month>
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<Title>Arquivos de neuro-psiquiatria</Title>
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<ArticleTitle>Working memory in Parkinson's disease patients: clinical features and response to levodopa.</ArticleTitle>
<Pagination><MedlinePgn>147-51</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To evaluate the clinical features of the working memory (WM) in Parkinson's disease (PD) patients and to test the effect of levodopa on WM.</AbstractText>
<AbstractText Label="METHOD" NlmCategory="METHODS">The paradigm was based on the 'n-back' tasks, which enables to study the level of executive demand (three levels of difficulty) and the domain of the information being processed (spatial items, faces and letters). The effect of levodopa was studied by testing PD patients in "on" and "off" states.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">PD patients performed less well in WM tasks than controls. There was no interaction between groups and complexity. Levodopa therapy had a positive effect only on spatial WM tasks but no effect on complexity.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results suggest that impairment observed may result from a maintenance deficit within WM regardless the level of processing and levodopa therapy presents a positive effect on spatial WM.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Beato</LastName>
<ForeName>Rogério</ForeName>
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<AffiliationInfo><Affiliation>INSERM U610, Groupe Hospitalier de la Pitié-Salpêtrière, Paris, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Levy</LastName>
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<Author ValidYN="Y"><LastName>Pillon</LastName>
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<Author ValidYN="Y"><LastName>Vidal</LastName>
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<Author ValidYN="Y"><LastName>du Montcel</LastName>
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<Author ValidYN="Y"><LastName>Houeto</LastName>
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<Language>eng</Language>
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