[Clinical interest of fMRI and functional exploration methods of brain activity and interactivity: physical and neurophysiological considerations].
Identifieur interne : 000C84 ( PubMed/Corpus ); précédent : 000C83; suivant : 000C85[Clinical interest of fMRI and functional exploration methods of brain activity and interactivity: physical and neurophysiological considerations].
Auteurs : G. De Marco ; C. Menuel ; R. Guillevin ; J-N Vallée ; P. Lehmann ; S. Fall ; V. Quaglino ; B. Bourdin ; B. Devauchelle ; J. ChirasSource :
- Journal of neuroradiology. Journal de neuroradiologie [ 0150-9861 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- pathology : Brain Diseases.
- physiopathology : Brain Diseases.
- therapy : Brain Diseases.
- Humans, Magnetic Resonance Imaging.
Abstract
After having provided a brief reminder of the principle of the blood oxygen level-dependent (BOLD) contrast effect, the physiological bases of brain activity and the concepts of functional integration and effective connectivity, we describe the most recent approaches, which permit to explore brain activity and putative networks of interconnected active areas in order to examine the normal brain physiology and its dysfunctions. We present various methods and studies of brain activity analysis clinically applicable, and we detail the concepts of functional and effective connectivity, which allow to study the cerebral plasticity which occurs at the child's during the maturation (e.g., dyslexia), at the adult during the ageing (e.g., Alzheimer disease), or still in schizophrenia or Parkinson disease. The study of specific circuits in networks has to allow defining in a more realistic way the dynamic of the central nervous system, which underlies various cerebral functions, both in physiological and pathological conditions. This connectivity approach should improve the diagnostic and facilitate the development of new therapeutic strategies.
DOI: 10.1016/j.neurad.2007.12.002
PubMed: 18206238
Links to Exploration step
pubmed:18206238Le document en format XML
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<front><div type="abstract" xml:lang="en">After having provided a brief reminder of the principle of the blood oxygen level-dependent (BOLD) contrast effect, the physiological bases of brain activity and the concepts of functional integration and effective connectivity, we describe the most recent approaches, which permit to explore brain activity and putative networks of interconnected active areas in order to examine the normal brain physiology and its dysfunctions. We present various methods and studies of brain activity analysis clinically applicable, and we detail the concepts of functional and effective connectivity, which allow to study the cerebral plasticity which occurs at the child's during the maturation (e.g., dyslexia), at the adult during the ageing (e.g., Alzheimer disease), or still in schizophrenia or Parkinson disease. The study of specific circuits in networks has to allow defining in a more realistic way the dynamic of the central nervous system, which underlies various cerebral functions, both in physiological and pathological conditions. This connectivity approach should improve the diagnostic and facilitate the development of new therapeutic strategies.</div>
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<Abstract><AbstractText>After having provided a brief reminder of the principle of the blood oxygen level-dependent (BOLD) contrast effect, the physiological bases of brain activity and the concepts of functional integration and effective connectivity, we describe the most recent approaches, which permit to explore brain activity and putative networks of interconnected active areas in order to examine the normal brain physiology and its dysfunctions. We present various methods and studies of brain activity analysis clinically applicable, and we detail the concepts of functional and effective connectivity, which allow to study the cerebral plasticity which occurs at the child's during the maturation (e.g., dyslexia), at the adult during the ageing (e.g., Alzheimer disease), or still in schizophrenia or Parkinson disease. The study of specific circuits in networks has to allow defining in a more realistic way the dynamic of the central nervous system, which underlies various cerebral functions, both in physiological and pathological conditions. This connectivity approach should improve the diagnostic and facilitate the development of new therapeutic strategies.</AbstractText>
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<VernacularTitle>Intérêt clinique de l'IRMf et des méthodes d'exploration fonctionnelle de l'activité et de l'interactivité cérébrales : considérations physiques et neurophysiologiques.</VernacularTitle>
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