Effects of Parkinson's disease on proprioceptive control of posture and reaching while standing.
Identifieur interne : 000C13 ( PubMed/Corpus ); précédent : 000C12; suivant : 000C14Effects of Parkinson's disease on proprioceptive control of posture and reaching while standing.
Auteurs : M. Tagliabue ; G. Ferrigno ; F. HorakSource :
- Neuroscience [ 0306-4522 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Biomechanical Phenomena, Case-Control Studies, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Movement (physiology), Parkinson Disease (physiopathology), Postural Balance (physiology), Posture, Principal Component Analysis, Proprioception (physiology), Psychomotor Performance, Time Factors, Visual Perception (physiology).
- MESH :
- physiology : Movement, Postural Balance, Proprioception, Visual Perception.
- physiopathology : Parkinson Disease.
- Aged, Biomechanical Phenomena, Case-Control Studies, Chi-Square Distribution, Female, Humans, Male, Middle Aged, Posture, Principal Component Analysis, Psychomotor Performance, Time Factors.
Abstract
Although previous studies have shown pointing errors and abnormal multijoint coordination in seated subjects with Parkinson's disease (PD) who cannot view their arm, the extent to which subjects with PD have problems using proprioception to coordinate equilibrium maintenance and goal-oriented task execution has not been adequately investigated. If a common motor program controls voluntary arm pointing movements and the accompanying postural adjustments, then impairments of proprioceptive integration in subjects with PD should have similar effects on pointing and body center of mass (CoM) control with eyes closed. Ten standing subjects with PD (OFF-medication) and 10 age-matched control (CTR) subjects pointed to a target with their eyes closed and open. Although pointing accuracy was not significantly different between groups, body CoM displacements were reduced in subjects with PD, but not in CTR, when eyes were closed. In addition, with eyes closed, PD subjects showed reduced temporal coupling between pointing and CoM velocity profiles and reduced spatial coupling between pointing and CoM endpoints. This poor coupling with eyes closed could be related to the PD subjects' increased jerkiness of CoM displacements. The different effects of eye closure between CTR and PD subjects on the CoM displacements, but not pointing accuracy, are consistent with separate motor programs for the pointing and postural components of this task. Furthermore, the decoupling between the two movement components in subjects with PD when they could not use vision, suggests that the basal ganglia are involved in the integration of proprioceptive information for posture-movement coordination.
DOI: 10.1016/j.neuroscience.2008.12.007
PubMed: 19136043
Links to Exploration step
pubmed:19136043Le document en format XML
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Horak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19136043</idno><idno type="pmid">19136043</idno><idno type="doi">10.1016/j.neuroscience.2008.12.007</idno><idno type="wicri:Area/PubMed/Corpus">000C13</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of Parkinson's disease on proprioceptive control of posture and reaching while standing.</title><author><name sortKey="Tagliabue, M" sort="Tagliabue, M" uniqKey="Tagliabue M" first="M" last="Tagliabue">M. Tagliabue</name><affiliation><nlm:affiliation>University Paris Descartes, 75270 Paris Cedex 06, France. michele.tagliabue@parisdescartes.fr</nlm:affiliation></affiliation></author><author><name sortKey="Ferrigno, G" sort="Ferrigno, G" uniqKey="Ferrigno G" first="G" last="Ferrigno">G. Ferrigno</name></author><author><name sortKey="Horak, F" sort="Horak, F" uniqKey="Horak F" first="F" last="Horak">F. Horak</name></author></analytic><series><title level="j">Neuroscience</title><idno type="ISSN">0306-4522</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Biomechanical Phenomena</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Movement (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Postural Balance (physiology)</term><term>Posture</term><term>Principal Component Analysis</term><term>Proprioception (physiology)</term><term>Psychomotor Performance</term><term>Time Factors</term><term>Visual Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Movement</term><term>Postural Balance</term><term>Proprioception</term><term>Visual Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Biomechanical Phenomena</term><term>Case-Control Studies</term><term>Chi-Square Distribution</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Posture</term><term>Principal Component Analysis</term><term>Psychomotor Performance</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although previous studies have shown pointing errors and abnormal multijoint coordination in seated subjects with Parkinson's disease (PD) who cannot view their arm, the extent to which subjects with PD have problems using proprioception to coordinate equilibrium maintenance and goal-oriented task execution has not been adequately investigated. If a common motor program controls voluntary arm pointing movements and the accompanying postural adjustments, then impairments of proprioceptive integration in subjects with PD should have similar effects on pointing and body center of mass (CoM) control with eyes closed. Ten standing subjects with PD (OFF-medication) and 10 age-matched control (CTR) subjects pointed to a target with their eyes closed and open. Although pointing accuracy was not significantly different between groups, body CoM displacements were reduced in subjects with PD, but not in CTR, when eyes were closed. In addition, with eyes closed, PD subjects showed reduced temporal coupling between pointing and CoM velocity profiles and reduced spatial coupling between pointing and CoM endpoints. This poor coupling with eyes closed could be related to the PD subjects' increased jerkiness of CoM displacements. The different effects of eye closure between CTR and PD subjects on the CoM displacements, but not pointing accuracy, are consistent with separate motor programs for the pointing and postural components of this task. Furthermore, the decoupling between the two movement components in subjects with PD when they could not use vision, suggests that the basal ganglia are involved in the integration of proprioceptive information for posture-movement coordination.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19136043</PMID><DateCreated><Year>2009</Year><Month>02</Month><Day>23</Day></DateCreated><DateCompleted><Year>2009</Year><Month>05</Month><Day>20</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0306-4522</ISSN><JournalIssue CitedMedium="Print"><Volume>158</Volume><Issue>4</Issue><PubDate><Year>2009</Year><Month>Feb</Month><Day>18</Day></PubDate></JournalIssue><Title>Neuroscience</Title><ISOAbbreviation>Neuroscience</ISOAbbreviation></Journal><ArticleTitle>Effects of Parkinson's disease on proprioceptive control of posture and reaching while standing.</ArticleTitle><Pagination><MedlinePgn>1206-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neuroscience.2008.12.007</ELocationID><Abstract><AbstractText>Although previous studies have shown pointing errors and abnormal multijoint coordination in seated subjects with Parkinson's disease (PD) who cannot view their arm, the extent to which subjects with PD have problems using proprioception to coordinate equilibrium maintenance and goal-oriented task execution has not been adequately investigated. If a common motor program controls voluntary arm pointing movements and the accompanying postural adjustments, then impairments of proprioceptive integration in subjects with PD should have similar effects on pointing and body center of mass (CoM) control with eyes closed. Ten standing subjects with PD (OFF-medication) and 10 age-matched control (CTR) subjects pointed to a target with their eyes closed and open. Although pointing accuracy was not significantly different between groups, body CoM displacements were reduced in subjects with PD, but not in CTR, when eyes were closed. In addition, with eyes closed, PD subjects showed reduced temporal coupling between pointing and CoM velocity profiles and reduced spatial coupling between pointing and CoM endpoints. This poor coupling with eyes closed could be related to the PD subjects' increased jerkiness of CoM displacements. The different effects of eye closure between CTR and PD subjects on the CoM displacements, but not pointing accuracy, are consistent with separate motor programs for the pointing and postural components of this task. Furthermore, the decoupling between the two movement components in subjects with PD when they could not use vision, suggests that the basal ganglia are involved in the integration of proprioceptive information for posture-movement coordination.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tagliabue</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University Paris Descartes, 75270 Paris Cedex 06, France. michele.tagliabue@parisdescartes.fr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrigno</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Horak</LastName><ForeName>F</ForeName><Initials>F</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AG006457</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AG006457</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 AG006457-22</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AG06457</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2008</Year><Month>12</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United 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UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009068" MajorTopicYN="N">Movement</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="N">Postural Balance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011187" MajorTopicYN="Y">Posture</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D025341" MajorTopicYN="N">Principal Component Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011434" MajorTopicYN="N">Proprioception</DescriptorName><QualifierName UI="Q000502" 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