Examination of the Lille Apathy Rating Scale in Parkinson disease.
Identifieur interne : 000B99 ( PubMed/Corpus ); précédent : 000B98; suivant : 000C00Examination of the Lille Apathy Rating Scale in Parkinson disease.
Auteurs : Laura B. Zahodne ; Shamar Young ; Lindsey Kirsch-Darrow ; Anne Nisenzon ; Hubert H. Fernandez ; Michael S. Okun ; Dawn BowersSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2009.
English descriptors
- KwdEn :
- Adult, Affect (physiology), Aged, Aged, 80 and over, Analysis of Variance, Depression (diagnosis), Depression (etiology), Female, Humans, Male, Middle Aged, Mood Disorders (diagnosis), Mood Disorders (etiology), Parkinson Disease (complications), Parkinson Disease (psychology), Psychiatric Status Rating Scales, ROC Curve, Reproducibility of Results.
- MESH :
- complications : Parkinson Disease.
- diagnosis : Depression, Mood Disorders.
- etiology : Depression, Mood Disorders.
- physiology : Affect.
- psychology : Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Analysis of Variance, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, ROC Curve, Reproducibility of Results.
Abstract
Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI-II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely-used measure, we identified a cut-off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cut-off by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD.
DOI: 10.1002/mds.22441
PubMed: 19133658
Links to Exploration step
pubmed:19133658Le document en format XML
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Zahodne</name><affiliation><nlm:affiliation>Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida 32610-0165, USA. lzahodne@phhp.ufl.edu</nlm:affiliation></affiliation></author><author><name sortKey="Young, Shamar" sort="Young, Shamar" uniqKey="Young S" first="Shamar" last="Young">Shamar Young</name></author><author><name sortKey="Kirsch Darrow, Lindsey" sort="Kirsch Darrow, Lindsey" uniqKey="Kirsch Darrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name></author><author><name sortKey="Nisenzon, Anne" sort="Nisenzon, Anne" uniqKey="Nisenzon A" first="Anne" last="Nisenzon">Anne Nisenzon</name></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19133658</idno><idno type="pmid">19133658</idno><idno type="doi">10.1002/mds.22441</idno><idno type="wicri:Area/PubMed/Corpus">000B99</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B99</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Examination of the Lille Apathy Rating Scale in Parkinson disease.</title><author><name sortKey="Zahodne, Laura B" sort="Zahodne, Laura B" uniqKey="Zahodne L" first="Laura B" last="Zahodne">Laura B. Zahodne</name><affiliation><nlm:affiliation>Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida 32610-0165, USA. lzahodne@phhp.ufl.edu</nlm:affiliation></affiliation></author><author><name sortKey="Young, Shamar" sort="Young, Shamar" uniqKey="Young S" first="Shamar" last="Young">Shamar Young</name></author><author><name sortKey="Kirsch Darrow, Lindsey" sort="Kirsch Darrow, Lindsey" uniqKey="Kirsch Darrow L" first="Lindsey" last="Kirsch-Darrow">Lindsey Kirsch-Darrow</name></author><author><name sortKey="Nisenzon, Anne" sort="Nisenzon, Anne" uniqKey="Nisenzon A" first="Anne" last="Nisenzon">Anne Nisenzon</name></author><author><name sortKey="Fernandez, Hubert H" sort="Fernandez, Hubert H" uniqKey="Fernandez H" first="Hubert H" last="Fernandez">Hubert H. Fernandez</name></author><author><name sortKey="Okun, Michael S" sort="Okun, Michael S" uniqKey="Okun M" first="Michael S" last="Okun">Michael S. Okun</name></author><author><name sortKey="Bowers, Dawn" sort="Bowers, Dawn" uniqKey="Bowers D" first="Dawn" last="Bowers">Dawn Bowers</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Affect (physiology)</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Depression (diagnosis)</term><term>Depression (etiology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mood Disorders (diagnosis)</term><term>Mood Disorders (etiology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (psychology)</term><term>Psychiatric Status Rating Scales</term><term>ROC Curve</term><term>Reproducibility of Results</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Depression</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Depression</term><term>Mood Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Psychiatric Status Rating Scales</term><term>ROC Curve</term><term>Reproducibility of Results</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI-II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely-used measure, we identified a cut-off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cut-off by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19133658</PMID><DateCreated><Year>2009</Year><Month>05</Month><Day>04</Day></DateCreated><DateCompleted><Year>2009</Year><Month>07</Month><Day>28</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8257</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>5</Issue><PubDate><Year>2009</Year><Month>Apr</Month><Day>15</Day></PubDate></JournalIssue><Title>Movement disorders : official journal of the Movement Disorder Society</Title><ISOAbbreviation>Mov. Disord.</ISOAbbreviation></Journal><ArticleTitle>Examination of the Lille Apathy Rating Scale in Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>677-83</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/mds.22441</ELocationID><Abstract><AbstractText>Apathy is a unique, multidimensional syndrome commonly encountered in patients with Parkinson disease (PD). Recently, the Lille Apathy Rating Scale (LARS), a semistructured interview yielding a global score, and composite subscores for different domains of apathy (i.e., cognitive, behavioral, affective, self awareness), was developed and given to a sample of patients with PD in France. This study is the first outside of its original developers to examine the English language version of the LARS in PD. We found the LARS to be a coherent instrument demonstrating both convergent and divergent validity, as compared to the Apathy Scale (AS) and Beck Depression Inventory (BDI-II). Using a receiver operating characteristic (ROC) analysis comparing the LARS to the AS, a validated and widely-used measure, we identified a cut-off score (sensitivity = 64%, specificity = 92%, PPV = 88%, NPV = 75%) that was higher than that proposed by the original authors, who derived their cut-off by comparing LARS global scores to clinical judgments of apathy. Although the present study does not compare the LARS to a diagnostic gold standard or promote its utility for diagnosing apathy, it provides further support for the LARS as a promising instrument to examine apathy in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zahodne</LastName><ForeName>Laura B</ForeName><Initials>LB</Initials><AffiliationInfo><Affiliation>Department of Clinical & Health Psychology, University of Florida, Gainesville, Florida 32610-0165, USA. lzahodne@phhp.ufl.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Shamar</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Kirsch-Darrow</LastName><ForeName>Lindsey</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Nisenzon</LastName><ForeName>Anne</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>Hubert H</ForeName><Initials>HH</Initials></Author><Author ValidYN="Y"><LastName>Okun</LastName><ForeName>Michael S</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Bowers</LastName><ForeName>Dawn</ForeName><Initials>D</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 NS050633</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AG020499</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 AG020499-09</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mov Disord</MedlineTA><NlmUniqueID>8610688</NlmUniqueID><ISSNLinking>0885-3185</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2006 Jul 11;67(1):33-8</RefSource><PMID Version="1">16832074</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2006 Oct;21(10):1656-62</RefSource><PMID Version="1">16830317</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2007 Apr 30;22(6):778-84</RefSource><PMID Version="1">17290451</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Nerve. 2007 Sep;59(9):935-42</RefSource><PMID Version="1">17886475</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Biosci. 2008;13:5316-22</RefSource><PMID Version="1">18508589</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2008 May 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Version="1">16207933</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000339" MajorTopicYN="N">Affect</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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