ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000A87

In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.

Identifieur interne : 000A87 ( PubMed/Corpus ); précédent : 000A86; suivant : 000A88

In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.

Auteurs : Stephane Besnard ; Michael Decressac ; Pierre Denise

Source :

Neuroreport [ 1473-558X ] ; 2010.

RBID : pubmed:20405544

English descriptors

KwdEn :
- Action Potentials, Animals, Disease Models, Animal, Electrophysiology, Female, Mice, Mice, Inbred C57BL, Neurons (physiology), Neurons (transplantation), Parkinson Disease (surgery), Substantia Nigra (cytology), Substantia Nigra (physiology).
MESH :
- cytology : Substantia Nigra.
- physiology : Neurons, Substantia Nigra.
- surgery : Parkinson Disease.
- transplantation : Neurons.
- Action Potentials, Animals, Disease Models, Animal, Electrophysiology, Female, Mice, Mice, Inbred C57BL.

Abstract

We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop.

PubMed: 20405544

Links to Exploration step

pubmed:20405544

Le document en format XML

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<author><name sortKey="Decressac, Michael" sort="Decressac, Michael" uniqKey="Decressac M" first="Michael" last="Decressac">Michael Decressac</name>
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<author><name sortKey="Denise, Pierre" sort="Denise, Pierre" uniqKey="Denise P" first="Pierre" last="Denise">Pierre Denise</name>
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<keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term>
<term>Animals</term>
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<front><div type="abstract" xml:lang="en">We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop.</div>
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In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.

In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki