In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.
Identifieur interne : 000A87 ( PubMed/Corpus ); précédent : 000A86; suivant : 000A88In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.
Auteurs : Stephane Besnard ; Michael Decressac ; Pierre DeniseSource :
- Neuroreport [ 1473-558X ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- cytology : Substantia Nigra.
- physiology : Neurons, Substantia Nigra.
- surgery : Parkinson Disease.
- transplantation : Neurons.
- Action Potentials, Animals, Disease Models, Animal, Electrophysiology, Female, Mice, Mice, Inbred C57BL.
Abstract
We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop.
PubMed: 20405544
Links to Exploration step
pubmed:20405544Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.</title>
<author><name sortKey="Besnard, Stephane" sort="Besnard, Stephane" uniqKey="Besnard S" first="Stephane" last="Besnard">Stephane Besnard</name>
<affiliation><nlm:affiliation>INSERM, Univ Caen, CHRU Caen, Explorations Fonctionnelles Neurologiques, Caen, France. stephane.besnard@unicaen.fr</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Decressac, Michael" sort="Decressac, Michael" uniqKey="Decressac M" first="Michael" last="Decressac">Michael Decressac</name>
</author>
<author><name sortKey="Denise, Pierre" sort="Denise, Pierre" uniqKey="Denise P" first="Pierre" last="Denise">Pierre Denise</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2010">2010</date>
<idno type="RBID">pubmed:20405544</idno>
<idno type="pmid">20405544</idno>
<idno type="wicri:Area/PubMed/Corpus">000A87</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A87</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.</title>
<author><name sortKey="Besnard, Stephane" sort="Besnard, Stephane" uniqKey="Besnard S" first="Stephane" last="Besnard">Stephane Besnard</name>
<affiliation><nlm:affiliation>INSERM, Univ Caen, CHRU Caen, Explorations Fonctionnelles Neurologiques, Caen, France. stephane.besnard@unicaen.fr</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Decressac, Michael" sort="Decressac, Michael" uniqKey="Decressac M" first="Michael" last="Decressac">Michael Decressac</name>
</author>
<author><name sortKey="Denise, Pierre" sort="Denise, Pierre" uniqKey="Denise P" first="Pierre" last="Denise">Pierre Denise</name>
</author>
</analytic>
<series><title level="j">Neuroreport</title>
<idno type="eISSN">1473-558X</idno>
<imprint><date when="2010" type="published">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials</term>
<term>Animals</term>
<term>Disease Models, Animal</term>
<term>Electrophysiology</term>
<term>Female</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Neurons (physiology)</term>
<term>Neurons (transplantation)</term>
<term>Parkinson Disease (surgery)</term>
<term>Substantia Nigra (cytology)</term>
<term>Substantia Nigra (physiology)</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term>
<term>Substantia Nigra</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="transplantation" xml:lang="en"><term>Neurons</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Action Potentials</term>
<term>Animals</term>
<term>Disease Models, Animal</term>
<term>Electrophysiology</term>
<term>Female</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20405544</PMID>
<DateCreated><Year>2010</Year>
<Month>04</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2010</Year>
<Month>07</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2010</Year>
<Month>04</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-558X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>21</Volume>
<Issue>7</Issue>
<PubDate><Year>2010</Year>
<Month>May</Month>
<Day>12</Day>
</PubDate>
</JournalIssue>
<Title>Neuroreport</Title>
<ISOAbbreviation>Neuroreport</ISOAbbreviation>
</Journal>
<ArticleTitle>In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>485-9</MedlinePgn>
</Pagination>
<Abstract><AbstractText>We recently showed that intranigral transplantation of embryonic neurons in a mouse model of Parkinson's disease led to anatomical and functional recovery of the nigrostriatal pathway. Here we report, in-vivo electrophysiological characteristics of these grafted neurons 2 months after transplantation. Extracellular activity was mapped within the transplant using microarray electrodes and exploration was done with antidromic and orthodromic striatal stimulation. Grafted neurons expressed spontaneous electrophysiological activity with dopaminergic-like characteristics, and antidromic and orthodromic responses suggest a functional recovery of the nigrostriatal loop.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Besnard</LastName>
<ForeName>Stephane</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>INSERM, Univ Caen, CHRU Caen, Explorations Fonctionnelles Neurologiques, Caen, France. stephane.besnard@unicaen.fr</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Decressac</LastName>
<ForeName>Michael</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Denise</LastName>
<ForeName>Pierre</ForeName>
<Initials>P</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Neuroreport</MedlineTA>
<NlmUniqueID>9100935</NlmUniqueID>
<ISSNLinking>0959-4965</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000200" MajorTopicYN="N">Action Potentials</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004594" MajorTopicYN="N">Electrophysiology</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
<QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013378" MajorTopicYN="N">Substantia Nigra</DescriptorName>
<QualifierName UI="Q000166" MajorTopicYN="Y">cytology</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year>
<Month>4</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2010</Year>
<Month>4</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2010</Year>
<Month>7</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">20405544</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000A87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:20405544 |texte= In-vivo deep brain recordings of intranigral grafted cells in a mouse model of Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:20405544" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |