Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease.
Identifieur interne : 000A79 ( PubMed/Corpus ); précédent : 000A78; suivant : 000A80Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease.
Auteurs : Fabien Dutheil ; Philippe Beaune ; Christophe Tzourio ; Marie-Anne Loriot ; Alexis ElbazSource :
- Archives of neurology [ 1538-3687 ] ; 2010.
English descriptors
- KwdEn :
- ATP Binding Cassette Transporter 1, ATP-Binding Cassette Transporters (genetics), Adolescent, Adult, Aged, Case-Control Studies, Confidence Intervals, Exons (genetics), Female, France (epidemiology), Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Mental Status Schedule, Middle Aged, Occupational Exposure (adverse effects), Occupational Exposure (statistics & numerical data), Parkinson Disease (epidemiology), Parkinson Disease (etiology), Parkinson Disease (genetics), Pesticides (toxicity), Polymorphism, Genetic (genetics), Risk Factors, Sex Factors, Young Adult.
- MESH :
- chemical , toxicity : Pesticides.
- chemical : ATP Binding Cassette Transporter 1.
- geographic , epidemiology : France.
- adverse effects : Occupational Exposure.
- epidemiology : Parkinson Disease.
- etiology : Parkinson Disease.
- genetics : ATP-Binding Cassette Transporters, Exons, Parkinson Disease, Polymorphism, Genetic.
- statistics & numerical data : Occupational Exposure.
- Adolescent, Adult, Aged, Case-Control Studies, Confidence Intervals, Female, Gene Frequency, Genetic Predisposition to Disease, Humans, Male, Mental Status Schedule, Middle Aged, Risk Factors, Sex Factors, Young Adult.
Abstract
To study the association between Parkinson disease (PD) and 2 polymorphisms in ABCB1 among subjects enrolled in the French health system for agricultural workers (Mutualité Sociale Agricole), as well as the interaction between ABCB1 and organochlorine insecticides.
DOI: 10.1001/archneurol.2010.101
PubMed: 20558393
Links to Exploration step
pubmed:20558393Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease.</title><author><name sortKey="Dutheil, Fabien" sort="Dutheil, Fabien" uniqKey="Dutheil F" first="Fabien" last="Dutheil">Fabien Dutheil</name><affiliation><nlm:affiliation>INSERM UMR-S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beaune, Philippe" sort="Beaune, Philippe" uniqKey="Beaune P" first="Philippe" last="Beaune">Philippe Beaune</name></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20558393</idno><idno type="pmid">20558393</idno><idno type="doi">10.1001/archneurol.2010.101</idno><idno type="wicri:Area/PubMed/Corpus">000A79</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A79</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease.</title><author><name sortKey="Dutheil, Fabien" sort="Dutheil, Fabien" uniqKey="Dutheil F" first="Fabien" last="Dutheil">Fabien Dutheil</name><affiliation><nlm:affiliation>INSERM UMR-S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Université Paris Descartes, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beaune, Philippe" sort="Beaune, Philippe" uniqKey="Beaune P" first="Philippe" last="Beaune">Philippe Beaune</name></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></author><author><name sortKey="Loriot, Marie Anne" sort="Loriot, Marie Anne" uniqKey="Loriot M" first="Marie-Anne" last="Loriot">Marie-Anne Loriot</name></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name></author></analytic><series><title level="j">Archives of neurology</title><idno type="eISSN">1538-3687</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP Binding Cassette Transporter 1</term><term>ATP-Binding Cassette Transporters (genetics)</term><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Exons (genetics)</term><term>Female</term><term>France (epidemiology)</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Occupational Exposure (adverse effects)</term><term>Occupational Exposure (statistics & numerical data)</term><term>Parkinson Disease (epidemiology)</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (genetics)</term><term>Pesticides (toxicity)</term><term>Polymorphism, Genetic (genetics)</term><term>Risk Factors</term><term>Sex Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>ATP Binding Cassette Transporter 1</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>ATP-Binding Cassette Transporters</term><term>Exons</term><term>Parkinson Disease</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Confidence Intervals</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Mental Status Schedule</term><term>Middle Aged</term><term>Risk Factors</term><term>Sex Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To study the association between Parkinson disease (PD) and 2 polymorphisms in ABCB1 among subjects enrolled in the French health system for agricultural workers (Mutualité Sociale Agricole), as well as the interaction between ABCB1 and organochlorine insecticides.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20558393</PMID><DateCreated><Year>2010</Year><Month>06</Month><Day>18</Day></DateCreated><DateCompleted><Year>2010</Year><Month>07</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1538-3687</ISSN><JournalIssue CitedMedium="Internet"><Volume>67</Volume><Issue>6</Issue><PubDate><Year>2010</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Archives of neurology</Title><ISOAbbreviation>Arch. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Interaction between ABCB1 and professional exposure to organochlorine insecticides in Parkinson disease.</ArticleTitle><Pagination><MedlinePgn>739-45</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1001/archneurol.2010.101</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To study the association between Parkinson disease (PD) and 2 polymorphisms in ABCB1 among subjects enrolled in the French health system for agricultural workers (Mutualité Sociale Agricole), as well as the interaction between ABCB1 and organochlorine insecticides.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Case-control study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Mutualité Sociale Agricole.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">Patients with PD were examined by a neurologist and were matched to a maximum of 3 controls. Participants were classified as never users, users for gardening, and professional users of pesticides. Detailed information on pesticides lifelong use was obtained for professional users by occupational health physicians.</AbstractText><AbstractText Label="MAIN OUTCOME MEASURES" NlmCategory="METHODS">DNA was obtained and 2 ABCB1 polymorphisms (exon 21: G2677[A,T]; exon 26: C3435T) associated with altered P-glycoprotein function were genotyped.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 207 cases and 482 matched controls, ABCB1 polymorphisms were not associated with PD (C3435T, P = .43; G2677[A,T], P = .97). Among 101 male cases and 234 matched controls, the odds ratio for organochlorines was 3.5 (95% confidence interval, 0.9-14.5) times higher among homozygous carriers of variant G2677(A,T) alleles than noncarriers. Among cases only, we found an association between carrying 2 variant G2677(A,T) alleles and organochlorines (odds ratio, 5.4, 95% confidence interval, 1.1-27.5) as well as with the number of cumulative lifetime number of hours of exposure (P = .005; analyses restricted to subjects exposed to organochlorines, P = .03).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our findings suggest that the ABCB1 gene and exposure to organochlorine insecticides interact to increase PD risk: in subjects professionally exposed to organochlorines, polymorphisms associated with a decreased ability of ABCB1 to clear xenobiotics from the brain increased the risk of PD. These findings support the hypothesis of gene x pesticides interactions in PD.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dutheil</LastName><ForeName>Fabien</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM UMR-S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Université Paris Descartes, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beaune</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>Christophe</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Loriot</LastName><ForeName>Marie-Anne</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Elbaz</LastName><ForeName>Alexis</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Arch Neurol</MedlineTA><NlmUniqueID>0372436</NlmUniqueID><ISSNLinking>0003-9942</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064286">ATP Binding Cassette Transporter 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010575">Pesticides</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D064286" MajorTopicYN="N">ATP Binding Cassette Transporter 1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018528" MajorTopicYN="N">ATP-Binding Cassette Transporters</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016001" MajorTopicYN="N">Confidence Intervals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005091" MajorTopicYN="N">Exons</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005787" MajorTopicYN="N">Gene Frequency</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008609" MajorTopicYN="N">Mental Status Schedule</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016273" MajorTopicYN="N">Occupational Exposure</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="Y">Parkinson Disease</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010575" MajorTopicYN="N">Pesticides</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate 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