ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000A59

Biopsable neural tissues: toward new biomarkers for Parkinson's disease?

Identifieur interne : 000A59 ( PubMed/Corpus ); précédent : 000A58; suivant : 000A60

Biopsable neural tissues: toward new biomarkers for Parkinson's disease?

Auteurs : Thibaud Lebouvier ; Maddalena Tasselli ; Sébastien Paillusson ; Hélène Pouclet ; Michel Neunlist ; Pascal Derkinderen

Source :

Frontiers in psychiatry [ 1664-0640 ] ; 2010.

RBID : pubmed:21423439

Abstract

Biomarkers for Parkinson's disease (PD) are mainly intended for the early diagnosis of the disease and to monitor its progression, two aspects insufficiently covered by clinical evaluation. In the last 20 years, the search for biomarkers has been supported by technological advances in the fields of molecular genetics and neuroimaging. Nevertheless, no fully validated biomarker is yet available, and there is still a need for biomarkers that will complement those already available. Development of biomarkers for PD has been hampered by the fact that the core pathology lies in the brainstem, hidden from direct study in living patients. In this context, the recent observations that clearly demonstrated the presence of PD pathology in peripheral neural tissues provide new opportunities to develop original histopathological markers of the disease. Some of these peripheral tissues, especially the enteric nervous system, by being assessable using routine biopsies, could represent a window to assess in vivo the neuropathological processes occurring in PD.

DOI: 10.3389/fpsyt.2010.00128
PubMed: 21423439

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pubmed:21423439

Le document en format XML

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<author><name sortKey="Lebouvier, Thibaud" sort="Lebouvier, Thibaud" uniqKey="Lebouvier T" first="Thibaud" last="Lebouvier">Thibaud Lebouvier</name>
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<author><name sortKey="Tasselli, Maddalena" sort="Tasselli, Maddalena" uniqKey="Tasselli M" first="Maddalena" last="Tasselli">Maddalena Tasselli</name>
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<author><name sortKey="Paillusson, Sebastien" sort="Paillusson, Sebastien" uniqKey="Paillusson S" first="Sébastien" last="Paillusson">Sébastien Paillusson</name>
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<author><name sortKey="Neunlist, Michel" sort="Neunlist, Michel" uniqKey="Neunlist M" first="Michel" last="Neunlist">Michel Neunlist</name>
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<author><name sortKey="Derkinderen, Pascal" sort="Derkinderen, Pascal" uniqKey="Derkinderen P" first="Pascal" last="Derkinderen">Pascal Derkinderen</name>
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<front><div type="abstract" xml:lang="en">Biomarkers for Parkinson's disease (PD) are mainly intended for the early diagnosis of the disease and to monitor its progression, two aspects insufficiently covered by clinical evaluation. In the last 20 years, the search for biomarkers has been supported by technological advances in the fields of molecular genetics and neuroimaging. Nevertheless, no fully validated biomarker is yet available, and there is still a need for biomarkers that will complement those already available. Development of biomarkers for PD has been hampered by the fact that the core pathology lies in the brainstem, hidden from direct study in living patients. In this context, the recent observations that clearly demonstrated the presence of PD pathology in peripheral neural tissues provide new opportunities to develop original histopathological markers of the disease. Some of these peripheral tissues, especially the enteric nervous system, by being assessable using routine biopsies, could represent a window to assess in vivo the neuropathological processes occurring in PD.</div>
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<Abstract><AbstractText>Biomarkers for Parkinson's disease (PD) are mainly intended for the early diagnosis of the disease and to monitor its progression, two aspects insufficiently covered by clinical evaluation. In the last 20 years, the search for biomarkers has been supported by technological advances in the fields of molecular genetics and neuroimaging. Nevertheless, no fully validated biomarker is yet available, and there is still a need for biomarkers that will complement those already available. Development of biomarkers for PD has been hampered by the fact that the core pathology lies in the brainstem, hidden from direct study in living patients. In this context, the recent observations that clearly demonstrated the presence of PD pathology in peripheral neural tissues provide new opportunities to develop original histopathological markers of the disease. Some of these peripheral tissues, especially the enteric nervous system, by being assessable using routine biopsies, could represent a window to assess in vivo the neuropathological processes occurring in PD.</AbstractText>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Biopsable neural tissues: toward new biomarkers for Parkinson's disease?

Biopsable neural tissues: toward new biomarkers for Parkinson's disease?

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