[Parkinson's disease: Role of genetic and environment factors. Involvement in everyday clinical practice].
Identifieur interne : 000A45 ( PubMed/Corpus ); précédent : 000A44; suivant : 000A46[Parkinson's disease: Role of genetic and environment factors. Involvement in everyday clinical practice].
Auteurs : L. DefebvreSource :
- Revue neurologique [ 0035-3787 ] ; 2010.
English descriptors
- KwdEn :
- MESH :
- chemical , adverse effects : Pesticides.
- chemical , genetics : Protein-Serine-Threonine Kinases.
- chemical : Leucine-Rich Repeat Serine-Threonine Protein Kinase-2.
- adverse effects : Environmental Exposure.
- etiology : Parkinson Disease.
- genetics : Parkinson Disease.
- Genes, Dominant, Genes, Recessive, Humans, Occupational Exposure.
Abstract
Genetics and exposure to toxins constitute the main determinants in the onset of Parkinson's disease (PD). At least, 13 loci and nine genes involved in familial and sporadic forms have been described. A significant association between occupational exposure to pesticides (especially insecticides) and PD has been confirmed recently with rare cases even being recognized as occupational disease. We develop in this paper a practical approach for such situations where a common genetic or toxic origin is suggested. Such an approach can be applied very broadly using case by case study then further analysis in a specialized center of reference in the field of genetics or occupational diseases and the environment. A pedigree needs to be drawn to evaluate a potential genetic factor with, if possible, the examination of various family members. Depending on the mode of inheritance, age of disease onset and phenotypic expression, genetic analysis will be carried out (mainly the study of parkin gene for recessive transmission and LRRK2 gene for dominant transmission). The evaluation of a toxic factor is more difficult because its direct involvement may not always be defined with certainty, the collection of information is more complex (product list, causal relationship, protection system used...). The course of action will identify the existence of a potential risk factor particularly in patients at risk (farmers, workers in a factory using heavy metals) by considering secondary specialized consultation with the occupational physician or pathology consultation work for possible development of a procedure for recognition of occupational disease.
DOI: 10.1016/j.neurol.2010.07.014
PubMed: 20817232
Links to Exploration step
pubmed:20817232Le document en format XML
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Defebvre</name><affiliation><nlm:affiliation>CNRS FRE 3291, Service de Neurologie et Pathologie du Mouvement, Pôle de Neurologie, Hôpital Salengro, CHRU, Rue Emile-Laine, 59037 Lille Cedex, France. luc.defebvre@chru-lille.fr</nlm:affiliation></affiliation></author></analytic><series><title level="j">Revue neurologique</title><idno type="ISSN">0035-3787</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Environmental Exposure (adverse effects)</term><term>Genes, Dominant</term><term>Genes, Recessive</term><term>Humans</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Occupational Exposure</term><term>Parkinson Disease (etiology)</term><term>Parkinson Disease (genetics)</term><term>Pesticides (adverse effects)</term><term>Protein-Serine-Threonine Kinases (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Environmental Exposure</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genes, Dominant</term><term>Genes, Recessive</term><term>Humans</term><term>Occupational Exposure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetics and exposure to toxins constitute the main determinants in the onset of Parkinson's disease (PD). At least, 13 loci and nine genes involved in familial and sporadic forms have been described. A significant association between occupational exposure to pesticides (especially insecticides) and PD has been confirmed recently with rare cases even being recognized as occupational disease. We develop in this paper a practical approach for such situations where a common genetic or toxic origin is suggested. Such an approach can be applied very broadly using case by case study then further analysis in a specialized center of reference in the field of genetics or occupational diseases and the environment. A pedigree needs to be drawn to evaluate a potential genetic factor with, if possible, the examination of various family members. Depending on the mode of inheritance, age of disease onset and phenotypic expression, genetic analysis will be carried out (mainly the study of parkin gene for recessive transmission and LRRK2 gene for dominant transmission). The evaluation of a toxic factor is more difficult because its direct involvement may not always be defined with certainty, the collection of information is more complex (product list, causal relationship, protection system used...). The course of action will identify the existence of a potential risk factor particularly in patients at risk (farmers, workers in a factory using heavy metals) by considering secondary specialized consultation with the occupational physician or pathology consultation work for possible development of a procedure for recognition of occupational disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20817232</PMID><DateCreated><Year>2010</Year><Month>09</Month><Day>27</Day></DateCreated><DateCompleted><Year>2010</Year><Month>12</Month><Day>10</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0035-3787</ISSN><JournalIssue CitedMedium="Print"><Volume>166</Volume><Issue>10</Issue><PubDate><Year>2010</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Revue neurologique</Title><ISOAbbreviation>Rev. Neurol. (Paris)</ISOAbbreviation></Journal><ArticleTitle>[Parkinson's disease: Role of genetic and environment factors. Involvement in everyday clinical practice].</ArticleTitle><Pagination><MedlinePgn>764-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurol.2010.07.014</ELocationID><Abstract><AbstractText>Genetics and exposure to toxins constitute the main determinants in the onset of Parkinson's disease (PD). At least, 13 loci and nine genes involved in familial and sporadic forms have been described. A significant association between occupational exposure to pesticides (especially insecticides) and PD has been confirmed recently with rare cases even being recognized as occupational disease. We develop in this paper a practical approach for such situations where a common genetic or toxic origin is suggested. Such an approach can be applied very broadly using case by case study then further analysis in a specialized center of reference in the field of genetics or occupational diseases and the environment. A pedigree needs to be drawn to evaluate a potential genetic factor with, if possible, the examination of various family members. Depending on the mode of inheritance, age of disease onset and phenotypic expression, genetic analysis will be carried out (mainly the study of parkin gene for recessive transmission and LRRK2 gene for dominant transmission). The evaluation of a toxic factor is more difficult because its direct involvement may not always be defined with certainty, the collection of information is more complex (product list, causal relationship, protection system used...). The course of action will identify the existence of a potential risk factor particularly in patients at risk (farmers, workers in a factory using heavy metals) by considering secondary specialized consultation with the occupational physician or pathology consultation work for possible development of a procedure for recognition of occupational disease.</AbstractText><CopyrightInformation>Copyright © 2010 Elsevier Masson SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Defebvre</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>CNRS FRE 3291, Service de Neurologie et Pathologie du Mouvement, Pôle de Neurologie, Hôpital Salengro, CHRU, Rue Emile-Laine, 59037 Lille Cedex, France. luc.defebvre@chru-lille.fr</Affiliation></AffiliationInfo></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><VernacularTitle>Maladie de Parkinson : rôle des facteurs génétiques et environnementaux. 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