[From yeast to neurodegenerative diseases: ten years of exploration of mitochondrial dynamic disorders].
Identifieur interne : 000A39 ( PubMed/Corpus ); précédent : 000A38; suivant : 000A40[From yeast to neurodegenerative diseases: ten years of exploration of mitochondrial dynamic disorders].
Auteurs : Guy Lenaers ; Patrizia Amati-Bonneau ; Cécile Delettre ; Arnaud Chevrollier ; Christophe Verny ; Dan Miléa ; Vincent Procaccio ; Dominique Bonneau ; Christian Hamel ; Pascal ReynierSource :
- Medecine sciences : M/S [ 0767-0974 ] ; 2010.
English descriptors
- KwdEn :
- Axons (physiology), GTP Phosphohydrolases (genetics), Humans, Mitochondria (physiology), Mitochondrial Diseases (genetics), Mitochondrial Diseases (physiopathology), Neurodegenerative Diseases (genetics), Neurodegenerative Diseases (physiopathology), Optic Nerve Diseases (genetics), Oxidative Phosphorylation, Yeasts (physiology).
- MESH :
- chemical , genetics : GTP Phosphohydrolases.
- genetics : Mitochondrial Diseases, Neurodegenerative Diseases, Optic Nerve Diseases.
- physiology : Axons, Mitochondria, Yeasts.
- physiopathology : Mitochondrial Diseases, Neurodegenerative Diseases.
- Humans, Oxidative Phosphorylation.
Abstract
Ten years ago, OPA1 was identified as the major gene responsible for hereditary optic nerve degeneration, evidencing the first defect in mitochondrial network dynamics as the princeps pathophysiological mechanism in a mitochondriopathy. Later, alterations in other genes involved in mitochondrial fusion or fission, such as MFN2, DRP1 and GDAP1, were also associated with inherited neurological diseases, mainly affecting peripheral nerves. More recently, altered mitochondrial plasticity was also demonstrated in common age-related neurodegenerative disorders, as Alzheimer and Parkinson diseases, thus substantiating the critical role of mitochondrial dynamics in neurons as a key element governing the efficiency of oxidative respiration and its distribution along the axons.
DOI: 10.1051/medsci/20102610836
PubMed: 20929674
Links to Exploration step
pubmed:20929674Le document en format XML
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Christophe" uniqKey="Verny C" first="Christophe" last="Verny">Christophe Verny</name></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Miléa">Dan Miléa</name></author><author><name sortKey="Procaccio, Vincent" sort="Procaccio, Vincent" uniqKey="Procaccio V" first="Vincent" last="Procaccio">Vincent Procaccio</name></author><author><name sortKey="Bonneau, Dominique" sort="Bonneau, Dominique" uniqKey="Bonneau D" first="Dominique" last="Bonneau">Dominique Bonneau</name></author><author><name sortKey="Hamel, Christian" sort="Hamel, Christian" uniqKey="Hamel C" first="Christian" last="Hamel">Christian Hamel</name></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20929674</idno><idno type="pmid">20929674</idno><idno 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sortKey="Chevrollier, Arnaud" sort="Chevrollier, Arnaud" uniqKey="Chevrollier A" first="Arnaud" last="Chevrollier">Arnaud Chevrollier</name></author><author><name sortKey="Verny, Christophe" sort="Verny, Christophe" uniqKey="Verny C" first="Christophe" last="Verny">Christophe Verny</name></author><author><name sortKey="Milea, Dan" sort="Milea, Dan" uniqKey="Milea D" first="Dan" last="Miléa">Dan Miléa</name></author><author><name sortKey="Procaccio, Vincent" sort="Procaccio, Vincent" uniqKey="Procaccio V" first="Vincent" last="Procaccio">Vincent Procaccio</name></author><author><name sortKey="Bonneau, Dominique" sort="Bonneau, Dominique" uniqKey="Bonneau D" first="Dominique" last="Bonneau">Dominique Bonneau</name></author><author><name sortKey="Hamel, Christian" sort="Hamel, Christian" uniqKey="Hamel C" first="Christian" last="Hamel">Christian Hamel</name></author><author><name sortKey="Reynier, Pascal" sort="Reynier, Pascal" uniqKey="Reynier P" first="Pascal" last="Reynier">Pascal Reynier</name></author></analytic><series><title level="j">Medecine sciences : M/S</title><idno type="ISSN">0767-0974</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Axons (physiology)</term><term>GTP Phosphohydrolases (genetics)</term><term>Humans</term><term>Mitochondria (physiology)</term><term>Mitochondrial Diseases (genetics)</term><term>Mitochondrial Diseases (physiopathology)</term><term>Neurodegenerative Diseases (genetics)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Optic Nerve Diseases (genetics)</term><term>Oxidative Phosphorylation</term><term>Yeasts (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>GTP Phosphohydrolases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mitochondrial Diseases</term><term>Neurodegenerative Diseases</term><term>Optic Nerve Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Axons</term><term>Mitochondria</term><term>Yeasts</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Mitochondrial Diseases</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Oxidative Phosphorylation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ten years ago, OPA1 was identified as the major gene responsible for hereditary optic nerve degeneration, evidencing the first defect in mitochondrial network dynamics as the princeps pathophysiological mechanism in a mitochondriopathy. Later, alterations in other genes involved in mitochondrial fusion or fission, such as MFN2, DRP1 and GDAP1, were also associated with inherited neurological diseases, mainly affecting peripheral nerves. More recently, altered mitochondrial plasticity was also demonstrated in common age-related neurodegenerative disorders, as Alzheimer and Parkinson diseases, thus substantiating the critical role of mitochondrial dynamics in neurons as a key element governing the efficiency of oxidative respiration and its distribution along the axons.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20929674</PMID><DateCreated><Year>2010</Year><Month>10</Month><Day>08</Day></DateCreated><DateCompleted><Year>2010</Year><Month>12</Month><Day>22</Day></DateCompleted><DateRevised><Year>2010</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0767-0974</ISSN><JournalIssue CitedMedium="Print"><Volume>26</Volume><Issue>10</Issue><PubDate><Year>2010</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Medecine sciences : M/S</Title><ISOAbbreviation>Med Sci (Paris)</ISOAbbreviation></Journal><ArticleTitle>[From yeast to neurodegenerative diseases: ten years of exploration of mitochondrial dynamic disorders].</ArticleTitle><Pagination><MedlinePgn>836-41</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1051/medsci/20102610836</ELocationID><Abstract><AbstractText>Ten years ago, OPA1 was identified as the major gene responsible for hereditary optic nerve degeneration, evidencing the first defect in mitochondrial network dynamics as the princeps pathophysiological mechanism in a mitochondriopathy. Later, alterations in other genes involved in mitochondrial fusion or fission, such as MFN2, DRP1 and GDAP1, were also associated with inherited neurological diseases, mainly affecting peripheral nerves. More recently, altered mitochondrial plasticity was also demonstrated in common age-related neurodegenerative disorders, as Alzheimer and Parkinson diseases, thus substantiating the critical role of mitochondrial dynamics in neurons as a key element governing the efficiency of oxidative respiration and its distribution along the axons.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lenaers</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre hospitalier universitaire d'Angers, 49933 Angers Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amati-Bonneau</LastName><ForeName>Patrizia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Delettre</LastName><ForeName>Cécile</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Chevrollier</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Verny</LastName><ForeName>Christophe</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Miléa</LastName><ForeName>Dan</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Procaccio</LastName><ForeName>Vincent</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Bonneau</LastName><ForeName>Dominique</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Hamel</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Reynier</LastName><ForeName>Pascal</ForeName><Initials>P</Initials></Author></AuthorList><Language>fre</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><VernacularTitle>De la levure aux maladies neurodégénératives : dix ans d'exploration des pathologies de la dynamique mitochondriale.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Med Sci (Paris)</MedlineTA><NlmUniqueID>8710980</NlmUniqueID><ISSNLinking>0767-0974</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="D020558">GTP Phosphohydrolases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber><NameOfSubstance UI="C415198">OPA1 protein, human</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001369" MajorTopicYN="N">Axons</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020558" MajorTopicYN="N">GTP Phosphohydrolases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008928" MajorTopicYN="N">Mitochondria</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D028361" MajorTopicYN="N">Mitochondrial Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019636" MajorTopicYN="N">Neurodegenerative Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009901" MajorTopicYN="N">Optic Nerve Diseases</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010085" MajorTopicYN="N">Oxidative Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015003" MajorTopicYN="N">Yeasts</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>10</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>10</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>12</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20929674</ArticleId><ArticleId IdType="pii">00/00/0F/D5/</ArticleId><ArticleId IdType="doi">10.1051/medsci/20102610836</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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