Safety of rasagiline for the treatment of Parkinson's disease.
Identifieur interne : 000960 ( PubMed/Corpus ); précédent : 000959; suivant : 000961Safety of rasagiline for the treatment of Parkinson's disease.
Auteurs : Santiago Perez-Lloret ; Olivier RascolSource :
- Expert opinion on drug safety [ 1744-764X ] ; 2011.
English descriptors
- KwdEn :
- Animals, Clinical Trials as Topic (methods), Drug Interactions (physiology), Drug-Related Side Effects and Adverse Reactions (chemically induced), Drug-Related Side Effects and Adverse Reactions (metabolism), Drug-Related Side Effects and Adverse Reactions (prevention & control), Food-Drug Interactions (physiology), Humans, Indans (adverse effects), Indans (pharmacokinetics), Indans (therapeutic use), Parkinson Disease (drug therapy), Parkinson Disease (metabolism), Serotonin Agents (adverse effects), Serotonin Agents (pharmacokinetics), Serotonin Agents (therapeutic use), Treatment Outcome.
- MESH :
- chemical , adverse effects : Indans, Serotonin Agents.
- chemically induced : Drug-Related Side Effects and Adverse Reactions.
- drug therapy : Parkinson Disease.
- metabolism : Drug-Related Side Effects and Adverse Reactions, Parkinson Disease.
- methods : Clinical Trials as Topic.
- chemical , pharmacokinetics : Indans, Serotonin Agents.
- physiology : Drug Interactions, Food-Drug Interactions.
- prevention & control : Drug-Related Side Effects and Adverse Reactions.
- chemical , therapeutic use : Indans, Serotonin Agents.
- Animals, Humans, Treatment Outcome.
Abstract
Levodopa remains the gold standard treatment for Parkinson's disease (PD), but chronic treatment induces motor fluctuations and dyskinesias. Other dopaminergic agents, such as dopamine agonists, catechol-O-methyl transferase inhibitors and monoamine oxidase B enzyme inhibitors (MAO-B I) have also been developed to treat patients with PD. Rasagiline is a second generation MAO-B I inducing moderate symptomatic and possibly disease-modifying benefits with apparently good tolerability and safety profile in PD patients.
DOI: 10.1517/14740338.2011.573784
PubMed: 21453201
Links to Exploration step
pubmed:21453201Le document en format XML
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<author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name>
<affiliation><nlm:affiliation>Department of Clinical Pharmacology, Faculty of Medicine, Toulouse, France.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<author><name sortKey="Perez Lloret, Santiago" sort="Perez Lloret, Santiago" uniqKey="Perez Lloret S" first="Santiago" last="Perez-Lloret">Santiago Perez-Lloret</name>
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<author><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Clinical Trials as Topic (methods)</term>
<term>Drug Interactions (physiology)</term>
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<term>Drug-Related Side Effects and Adverse Reactions (metabolism)</term>
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<term>Food-Drug Interactions (physiology)</term>
<term>Humans</term>
<term>Indans (adverse effects)</term>
<term>Indans (pharmacokinetics)</term>
<term>Indans (therapeutic use)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Serotonin Agents (adverse effects)</term>
<term>Serotonin Agents (pharmacokinetics)</term>
<term>Serotonin Agents (therapeutic use)</term>
<term>Treatment Outcome</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Indans</term>
<term>Serotonin Agents</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Drug-Related Side Effects and Adverse Reactions</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Indans</term>
<term>Serotonin Agents</term>
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<term>Food-Drug Interactions</term>
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<front><div type="abstract" xml:lang="en">Levodopa remains the gold standard treatment for Parkinson's disease (PD), but chronic treatment induces motor fluctuations and dyskinesias. Other dopaminergic agents, such as dopamine agonists, catechol-O-methyl transferase inhibitors and monoamine oxidase B enzyme inhibitors (MAO-B I) have also been developed to treat patients with PD. Rasagiline is a second generation MAO-B I inducing moderate symptomatic and possibly disease-modifying benefits with apparently good tolerability and safety profile in PD patients.</div>
</front>
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<Day>13</Day>
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<Month>05</Month>
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<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-764X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>10</Volume>
<Issue>4</Issue>
<PubDate><Year>2011</Year>
<Month>Jul</Month>
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<Title>Expert opinion on drug safety</Title>
<ISOAbbreviation>Expert Opin Drug Saf</ISOAbbreviation>
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<ArticleTitle>Safety of rasagiline for the treatment of Parkinson's disease.</ArticleTitle>
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<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Levodopa remains the gold standard treatment for Parkinson's disease (PD), but chronic treatment induces motor fluctuations and dyskinesias. Other dopaminergic agents, such as dopamine agonists, catechol-O-methyl transferase inhibitors and monoamine oxidase B enzyme inhibitors (MAO-B I) have also been developed to treat patients with PD. Rasagiline is a second generation MAO-B I inducing moderate symptomatic and possibly disease-modifying benefits with apparently good tolerability and safety profile in PD patients.</AbstractText>
<AbstractText Label="AREAS COVERED" NlmCategory="METHODS">The safety of rasagiline in early or advanced PD is discussed. Details about clinical trial data, post hoc analysis in the elderly or regarding cognitive or behavioral effects, food-drug interactions and effects on levodopa-induced dyskinesias are given.</AbstractText>
<AbstractText Label="EXPERT OPINION" NlmCategory="CONCLUSIONS">Rasagiline is effective and well tolerated in PD as monotherapy or in combination with levodopa. There was no evidence of a difference in tolerability between younger or older PD patients included in published trials. Food interactions studies with tyramine did not provide evidence of clinical concerns. Drug interaction should be monitored. The risk of serotonin toxicity with serotoninergic antidepressants remains insufficiently characterized, while current available data in small groups of subjects suggest a low risk.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Perez-Lloret</LastName>
<ForeName>Santiago</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Pharmacology, Faculty of Medicine, Toulouse, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Rascol</LastName>
<ForeName>Olivier</ForeName>
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<CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Expert Opin Drug Saf. 2012 Mar;11(2):355</RefSource>
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<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
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<QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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