Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.
Identifieur interne : 000881 ( PubMed/Corpus ); précédent : 000880; suivant : 000882Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.
Auteurs : Virginie Bonnamain ; Isabelle Neveu ; Philippe NaveilhanSource :
- Frontiers in cellular neuroscience [ 1662-5102 ] ; 2012.
Abstract
Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases using fetal human neuroblasts, several significant limitations led to the search for alternative cell sources that would be more suitable for intracerebral transplantation.Taking into account logistical and ethical issues linked to the use of tissue derived from human fetuses, and the immunologically special status of the CNS allowing the occurrence of deleterious immune reactions, neural stem/progenitor cells (NSPCs) appear to be an interesting cell source candidate. In addition to their ability for replacing cell populations lost during the pathological events, NSPCs also display surprising therapeutic effects of neuroprotection and immunomodulation. A better knowledge of the mechanisms involved in these specific characteristics will hopefully lead in the future to a successful use of NSPCs in regenerative medicine for CNS disorders.
DOI: 10.3389/fncel.2012.00017
PubMed: 22514520
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pubmed:22514520Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.</title><author><name sortKey="Bonnamain, Virginie" sort="Bonnamain, Virginie" uniqKey="Bonnamain V" first="Virginie" last="Bonnamain">Virginie Bonnamain</name><affiliation><nlm:affiliation>INSERM U643, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name></author><author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22514520</idno><idno type="pmid">22514520</idno><idno type="doi">10.3389/fncel.2012.00017</idno><idno type="wicri:Area/PubMed/Corpus">000881</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000881</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.</title><author><name sortKey="Bonnamain, Virginie" sort="Bonnamain, Virginie" uniqKey="Bonnamain V" first="Virginie" last="Bonnamain">Virginie Bonnamain</name><affiliation><nlm:affiliation>INSERM U643, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Neveu, Isabelle" sort="Neveu, Isabelle" uniqKey="Neveu I" first="Isabelle" last="Neveu">Isabelle Neveu</name></author><author><name sortKey="Naveilhan, Philippe" sort="Naveilhan, Philippe" uniqKey="Naveilhan P" first="Philippe" last="Naveilhan">Philippe Naveilhan</name></author></analytic><series><title level="j">Frontiers in cellular neuroscience</title><idno type="eISSN">1662-5102</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases using fetal human neuroblasts, several significant limitations led to the search for alternative cell sources that would be more suitable for intracerebral transplantation.Taking into account logistical and ethical issues linked to the use of tissue derived from human fetuses, and the immunologically special status of the CNS allowing the occurrence of deleterious immune reactions, neural stem/progenitor cells (NSPCs) appear to be an interesting cell source candidate. In addition to their ability for replacing cell populations lost during the pathological events, NSPCs also display surprising therapeutic effects of neuroprotection and immunomodulation. A better knowledge of the mechanisms involved in these specific characteristics will hopefully lead in the future to a successful use of NSPCs in regenerative medicine for CNS disorders.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">22514520</PMID><DateCreated><Year>2012</Year><Month>04</Month><Day>19</Day></DateCreated><DateCompleted><Year>2012</Year><Month>10</Month><Day>02</Day></DateCompleted><DateRevised><Year>2013</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1662-5102</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2012</Year></PubDate></JournalIssue><Title>Frontiers in cellular neuroscience</Title><ISOAbbreviation>Front Cell Neurosci</ISOAbbreviation></Journal><ArticleTitle>Neural stem/progenitor cells as a promising candidate for regenerative therapy of the central nervous system.</ArticleTitle><Pagination><MedlinePgn>17</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3389/fncel.2012.00017</ELocationID><Abstract><AbstractText>Neural transplantation is a promising therapeutic strategy for neurodegenerative diseases and other disorders of the central nervous system (CNS) such as Parkinson and Huntington diseases, multiple sclerosis or stroke. Although cell replacement therapy already went through clinical trials for some of these diseases using fetal human neuroblasts, several significant limitations led to the search for alternative cell sources that would be more suitable for intracerebral transplantation.Taking into account logistical and ethical issues linked to the use of tissue derived from human fetuses, and the immunologically special status of the CNS allowing the occurrence of deleterious immune reactions, neural stem/progenitor cells (NSPCs) appear to be an interesting cell source candidate. In addition to their ability for replacing cell populations lost during the pathological events, NSPCs also display surprising therapeutic effects of neuroprotection and immunomodulation. A better knowledge of the mechanisms involved in these specific characteristics will hopefully lead in the future to a successful use of NSPCs in regenerative medicine for CNS disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bonnamain</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>INSERM U643, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neveu</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Naveilhan</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Front Cell 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