[Apathy in Parkinson's disease: clinical features, mechanisms and assessment].
Identifieur interne : 000844 ( PubMed/Corpus ); précédent : 000843; suivant : 000845[Apathy in Parkinson's disease: clinical features, mechanisms and assessment].
Auteurs : K. Dujardin ; L. DefebvreSource :
- Revue neurologique [ 0035-3787 ]
English descriptors
- KwdEn :
- Apathy (physiology), Basal Ganglia (physiopathology), Cognition Disorders (diagnosis), Cognition Disorders (etiology), Cognition Disorders (psychology), Gyrus Cinguli (physiopathology), Humans, Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (psychology).
- MESH :
- complications : Parkinson Disease.
- diagnosis : Cognition Disorders, Parkinson Disease.
- etiology : Cognition Disorders.
- physiology : Apathy.
- physiopathology : Basal Ganglia, Gyrus Cinguli, Parkinson Disease.
- psychology : Cognition Disorders, Parkinson Disease.
- Humans, Neuropsychological Tests.
Abstract
Apathy is a loss of motivation compared to the previous level of functioning of the subject. It affects the subject's behavior, cognition and emotional state. It is one of the main behavioral manifestations of Parkinson's disease. Although it may be a symptom of depression, it often exists as an isolated syndrome in Parkinson's disease patients. Apathy is usually not related to the severity of the motor symptoms, but frequently associated with the severity of cognitive impairment. Apathy is also a possible complication of treatment by stimulation of the subthalamic nucleus. Screening and assessment of apathy require the use of specific tools, some of which are validated in Parkinson's disease. From a pathophysiological point of view, apathy results from a dysfunction of the limbic circuit connecting the ventral striatum to orbitofrontal and anterior cingulate cortex. The dopaminergic denervation in these regions seems to play a key role, but other mechanisms are probably involved. Further studies are warranted to progress in the therapeutic management of this invalidating syndrome.
DOI: 10.1016/j.neurol.2012.05.002
PubMed: 22926025
Links to Exploration step
pubmed:22926025Le document en format XML
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Defebvre</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2012 Aug-Sep</MedlineDate></PubDate></date><idno type="RBID">pubmed:22926025</idno><idno type="pmid">22926025</idno><idno type="doi">10.1016/j.neurol.2012.05.002</idno><idno type="wicri:Area/PubMed/Corpus">000844</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000844</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Apathy in Parkinson's disease: clinical features, mechanisms and assessment].</title><author><name sortKey="Dujardin, K" sort="Dujardin, K" uniqKey="Dujardin K" first="K" last="Dujardin">K. Dujardin</name><affiliation><nlm:affiliation>Service de neurologie et pathologie du mouvement, hôpital Salengro, CHU, Lille cedex, France. kathy.dujardin@univ-lille2.fr</nlm:affiliation></affiliation></author><author><name sortKey="Defebvre, L" sort="Defebvre, L" uniqKey="Defebvre L" first="L" last="Defebvre">L. Defebvre</name></author></analytic><series><title level="j">Revue neurologique</title><idno type="ISSN">0035-3787</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apathy (physiology)</term><term>Basal Ganglia (physiopathology)</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Cognition Disorders (psychology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apathy</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term><term>Gyrus Cinguli</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Cognition Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is a loss of motivation compared to the previous level of functioning of the subject. It affects the subject's behavior, cognition and emotional state. It is one of the main behavioral manifestations of Parkinson's disease. Although it may be a symptom of depression, it often exists as an isolated syndrome in Parkinson's disease patients. Apathy is usually not related to the severity of the motor symptoms, but frequently associated with the severity of cognitive impairment. Apathy is also a possible complication of treatment by stimulation of the subthalamic nucleus. Screening and assessment of apathy require the use of specific tools, some of which are validated in Parkinson's disease. From a pathophysiological point of view, apathy results from a dysfunction of the limbic circuit connecting the ventral striatum to orbitofrontal and anterior cingulate cortex. The dopaminergic denervation in these regions seems to play a key role, but other mechanisms are probably involved. 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(Paris)</ISOAbbreviation></Journal><ArticleTitle>[Apathy in Parkinson's disease: clinical features, mechanisms and assessment].</ArticleTitle><Pagination><MedlinePgn>598-604</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.neurol.2012.05.002</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0035-3787(12)00869-7</ELocationID><Abstract><AbstractText>Apathy is a loss of motivation compared to the previous level of functioning of the subject. It affects the subject's behavior, cognition and emotional state. It is one of the main behavioral manifestations of Parkinson's disease. Although it may be a symptom of depression, it often exists as an isolated syndrome in Parkinson's disease patients. Apathy is usually not related to the severity of the motor symptoms, but frequently associated with the severity of cognitive impairment. Apathy is also a possible complication of treatment by stimulation of the subthalamic nucleus. Screening and assessment of apathy require the use of specific tools, some of which are validated in Parkinson's disease. From a pathophysiological point of view, apathy results from a dysfunction of the limbic circuit connecting the ventral striatum to orbitofrontal and anterior cingulate cortex. The dopaminergic denervation in these regions seems to play a key role, but other mechanisms are probably involved. Further studies are warranted to progress in the therapeutic management of this invalidating syndrome.</AbstractText><CopyrightInformation>Copyright © 2012 Elsevier Masson SAS. 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