Normal and pathological gait: what we learn from Parkinson's disease.
Identifieur interne : 000825 ( PubMed/Corpus ); précédent : 000824; suivant : 000826Normal and pathological gait: what we learn from Parkinson's disease.
Auteurs : David Grabli ; Carine Karachi ; Marie-Laure Welter ; Brian Lau ; Etienne C. Hirsch ; Marie Vidailhet ; Chantal FrançoisSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2012.
English descriptors
- KwdEn :
- Accidental Falls, Brain Stem (metabolism), Brain Stem (physiopathology), Cerebellum (metabolism), Cerebellum (physiopathology), Cerebral Cortex (metabolism), Cerebral Cortex (physiopathology), Controlled Clinical Trials as Topic, Deep Brain Stimulation, Dopamine (metabolism), Epinephrine (metabolism), Gait (physiology), Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (metabolism), Gait Disorders, Neurologic (physiopathology), Gait Disorders, Neurologic (therapy), Humans, Parkinson Disease (complications), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Postural Balance, Serotonin (metabolism).
- MESH :
- chemical , metabolism : Dopamine, Epinephrine, Serotonin.
- complications : Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- metabolism : Brain Stem, Cerebellum, Cerebral Cortex, Gait Disorders, Neurologic, Parkinson Disease.
- physiology : Gait.
- physiopathology : Brain Stem, Cerebellum, Cerebral Cortex, Gait Disorders, Neurologic, Parkinson Disease.
- therapy : Gait Disorders, Neurologic, Parkinson Disease.
- Accidental Falls, Controlled Clinical Trials as Topic, Deep Brain Stimulation, Humans, Postural Balance.
Abstract
Gait and balance disorders represent a major therapeutic challenge in Parkinson's disease (PD). These symptoms respond poorly to dopaminergic treatments, except in the early phase of the disease. Currently, no other treatment is particularly efficient and rehabilitation appears to be the most effective approach. Since these gait and balance deficits are resistant to dopaminergic drugs, their occurrence could be related to the development of extradopaminergic lesions in PD patients. We provide a comprehensive description of the clinical features of gait and balance disorders in PD. We also highlight the brain networks involved in gait and balance control in animals and humans with a particular focus on the relevant structures in the context of PD, such as the mesencephalic locomotor region. We also review other neuronal systems that may be involved in the physiopathology of gait and balance disorders in PD (noradrenergic and serotoninergic systems, cerebellum and cortex). In addition, we review recent evidence regarding functional neurosurgery for gait disorders in PD and propose new directions for future therapeutic research.
DOI: 10.1136/jnnp-2012-302263
PubMed: 22752693
Links to Exploration step
pubmed:22752693Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Normal and pathological gait: what we learn from Parkinson's disease.</title><author><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><affiliation><nlm:affiliation>Université Pierre et Marie Curie-Paris 6, CR-ICM, UMR-S975, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></author><author><name sortKey="Lau, Brian" sort="Lau, Brian" uniqKey="Lau B" first="Brian" last="Lau">Brian Lau</name></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22752693</idno><idno type="pmid">22752693</idno><idno type="doi">10.1136/jnnp-2012-302263</idno><idno type="wicri:Area/PubMed/Corpus">000825</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000825</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Normal and pathological gait: what we learn from Parkinson's disease.</title><author><name sortKey="Grabli, David" sort="Grabli, David" uniqKey="Grabli D" first="David" last="Grabli">David Grabli</name><affiliation><nlm:affiliation>Université Pierre et Marie Curie-Paris 6, CR-ICM, UMR-S975, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Karachi, Carine" sort="Karachi, Carine" uniqKey="Karachi C" first="Carine" last="Karachi">Carine Karachi</name></author><author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name></author><author><name sortKey="Lau, Brian" sort="Lau, Brian" uniqKey="Lau B" first="Brian" last="Lau">Brian Lau</name></author><author><name sortKey="Hirsch, Etienne C" sort="Hirsch, Etienne C" uniqKey="Hirsch E" first="Etienne C" last="Hirsch">Etienne C. Hirsch</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Francois, Chantal" sort="Francois, Chantal" uniqKey="Francois C" first="Chantal" last="François">Chantal François</name></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="eISSN">1468-330X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Accidental Falls</term><term>Brain Stem (metabolism)</term><term>Brain Stem (physiopathology)</term><term>Cerebellum (metabolism)</term><term>Cerebellum (physiopathology)</term><term>Cerebral Cortex (metabolism)</term><term>Cerebral Cortex (physiopathology)</term><term>Controlled Clinical Trials as Topic</term><term>Deep Brain Stimulation</term><term>Dopamine (metabolism)</term><term>Epinephrine (metabolism)</term><term>Gait (physiology)</term><term>Gait Disorders, Neurologic (etiology)</term><term>Gait Disorders, Neurologic (metabolism)</term><term>Gait Disorders, Neurologic (physiopathology)</term><term>Gait Disorders, Neurologic (therapy)</term><term>Humans</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Postural Balance</term><term>Serotonin (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Epinephrine</term><term>Serotonin</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Stem</term><term>Cerebellum</term><term>Cerebral Cortex</term><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Gait</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain Stem</term><term>Cerebellum</term><term>Cerebral Cortex</term><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Gait Disorders, Neurologic</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Accidental Falls</term><term>Controlled Clinical Trials as Topic</term><term>Deep Brain Stimulation</term><term>Humans</term><term>Postural Balance</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Gait and balance disorders represent a major therapeutic challenge in Parkinson's disease (PD). These symptoms respond poorly to dopaminergic treatments, except in the early phase of the disease. Currently, no other treatment is particularly efficient and rehabilitation appears to be the most effective approach. Since these gait and balance deficits are resistant to dopaminergic drugs, their occurrence could be related to the development of extradopaminergic lesions in PD patients. We provide a comprehensive description of the clinical features of gait and balance disorders in PD. We also highlight the brain networks involved in gait and balance control in animals and humans with a particular focus on the relevant structures in the context of PD, such as the mesencephalic locomotor region. We also review other neuronal systems that may be involved in the physiopathology of gait and balance disorders in PD (noradrenergic and serotoninergic systems, cerebellum and cortex). In addition, we review recent evidence regarding functional neurosurgery for gait disorders in PD and propose new directions for future therapeutic research.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22752693</PMID><DateCreated><Year>2012</Year><Month>09</Month><Day>10</Day></DateCreated><DateCompleted><Year>2012</Year><Month>11</Month><Day>27</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-330X</ISSN><JournalIssue CitedMedium="Internet"><Volume>83</Volume><Issue>10</Issue><PubDate><Year>2012</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>Normal and pathological gait: what we learn from Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>979-85</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/jnnp-2012-302263</ELocationID><Abstract><AbstractText>Gait and balance disorders represent a major therapeutic challenge in Parkinson's disease (PD). These symptoms respond poorly to dopaminergic treatments, except in the early phase of the disease. Currently, no other treatment is particularly efficient and rehabilitation appears to be the most effective approach. Since these gait and balance deficits are resistant to dopaminergic drugs, their occurrence could be related to the development of extradopaminergic lesions in PD patients. We provide a comprehensive description of the clinical features of gait and balance disorders in PD. We also highlight the brain networks involved in gait and balance control in animals and humans with a particular focus on the relevant structures in the context of PD, such as the mesencephalic locomotor region. We also review other neuronal systems that may be involved in the physiopathology of gait and balance disorders in PD (noradrenergic and serotoninergic systems, cerebellum and cortex). In addition, we review recent evidence regarding functional neurosurgery for gait disorders in PD and propose new directions for future therapeutic research.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grabli</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Université Pierre et Marie Curie-Paris 6, CR-ICM, UMR-S975, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karachi</LastName><ForeName>Carine</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Welter</LastName><ForeName>Marie-Laure</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Lau</LastName><ForeName>Brian</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Hirsch</LastName><ForeName>Etienne C</ForeName><Initials>EC</Initials></Author><Author ValidYN="Y"><LastName>Vidailhet</LastName><ForeName>Marie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>François</LastName><ForeName>Chantal</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>T32 MH015144</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>06</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>333DO1RDJY</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004856" MajorTopicYN="Y">Postural Balance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012701" MajorTopicYN="N">Serotonin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS527526</OtherID><OtherID Source="NLM">PMC3852420</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>7</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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|texte= Normal and pathological gait: what we learn from Parkinson's disease.
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