ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000821

Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.

Identifieur interne : 000821 ( PubMed/Corpus ); précédent : 000820; suivant : 000822

Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.

Auteurs : Alexandra Foubert-Samier ; Catherine Helmer ; Florian Perez ; Mélanie Le Goff ; Sophie Auriacombe ; Alexis Elbaz ; Jean-François Dartigues ; François Tison

Source :

Neurology [ 1526-632X ] ; 2012.

RBID : pubmed:23019267

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Antipsychotic Agents (therapeutic use), Cohort Studies, Female, France (epidemiology), Humans, Incidence, Male, Parkinson Disease (epidemiology), Parkinson Disease (etiology), Prevalence, Prospective Studies, Risk.
MESH :
- chemical , therapeutic use : Antipsychotic Agents.
- geographic , epidemiology : France.
- epidemiology : Parkinson Disease.
- etiology : Parkinson Disease.
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Incidence, Male, Prevalence, Prospective Studies, Risk.

Abstract

Neuroleptics and neuroleptic-like drugs are known to induce parkinsonism, which may reveal underlying Parkinson disease (PD) in some cases. We assessed the long-term risk of developing PD after past exposure to these drugs, in a 15-year prospective population-based elderly cohort study.

DOI: 10.1212/WNL.0b013e31826e25ce
PubMed: 23019267

Links to Exploration step

pubmed:23019267

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.</title>
<author><name sortKey="Foubert Samier, Alexandra" sort="Foubert Samier, Alexandra" uniqKey="Foubert Samier A" first="Alexandra" last="Foubert-Samier">Alexandra Foubert-Samier</name>
<affiliation><nlm:affiliation>INSERM Unit 897, Bordeaux, France. alexandra.foubert@isped.u-bordeaux2.fr</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name>
</author>
<author><name sortKey="Perez, Florian" sort="Perez, Florian" uniqKey="Perez F" first="Florian" last="Perez">Florian Perez</name>
</author>
<author><name sortKey="Le Goff, Melanie" sort="Le Goff, Melanie" uniqKey="Le Goff M" first="Mélanie" last="Le Goff">Mélanie Le Goff</name>
</author>
<author><name sortKey="Auriacombe, Sophie" sort="Auriacombe, Sophie" uniqKey="Auriacombe S" first="Sophie" last="Auriacombe">Sophie Auriacombe</name>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
</author>
<author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
</author>
<author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.</title>
<author><name sortKey="Foubert Samier, Alexandra" sort="Foubert Samier, Alexandra" uniqKey="Foubert Samier A" first="Alexandra" last="Foubert-Samier">Alexandra Foubert-Samier</name>
<affiliation><nlm:affiliation>INSERM Unit 897, Bordeaux, France. alexandra.foubert@isped.u-bordeaux2.fr</nlm:affiliation>
</affiliation>
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<author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name>
</author>
<author><name sortKey="Perez, Florian" sort="Perez, Florian" uniqKey="Perez F" first="Florian" last="Perez">Florian Perez</name>
</author>
<author><name sortKey="Le Goff, Melanie" sort="Le Goff, Melanie" uniqKey="Le Goff M" first="Mélanie" last="Le Goff">Mélanie Le Goff</name>
</author>
<author><name sortKey="Auriacombe, Sophie" sort="Auriacombe, Sophie" uniqKey="Auriacombe S" first="Sophie" last="Auriacombe">Sophie Auriacombe</name>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
</author>
<author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name>
</author>
<author><name sortKey="Tison, Francois" sort="Tison, Francois" uniqKey="Tison F" first="François" last="Tison">François Tison</name>
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<series><title level="j">Neurology</title>
<idno type="eISSN">1526-632X</idno>
<imprint><date when="2012" type="published">2012</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antipsychotic Agents (therapeutic use)</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>France (epidemiology)</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (etiology)</term>
<term>Prevalence</term>
<term>Prospective Studies</term>
<term>Risk</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antipsychotic Agents</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Prevalence</term>
<term>Prospective Studies</term>
<term>Risk</term>
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<front><div type="abstract" xml:lang="en">Neuroleptics and neuroleptic-like drugs are known to induce parkinsonism, which may reveal underlying Parkinson disease (PD) in some cases. We assessed the long-term risk of developing PD after past exposure to these drugs, in a 15-year prospective population-based elderly cohort study.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23019267</PMID>
<DateCreated><Year>2012</Year>
<Month>10</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>01</Month>
<Day>11</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>79</Volume>
<Issue>15</Issue>
<PubDate><Year>2012</Year>
<Month>Oct</Month>
<Day>09</Day>
</PubDate>
</JournalIssue>
<Title>Neurology</Title>
<ISOAbbreviation>Neurology</ISOAbbreviation>
</Journal>
<ArticleTitle>Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.</ArticleTitle>
<Pagination><MedlinePgn>1615-21</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0b013e31826e25ce</ELocationID>
<Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Neuroleptics and neuroleptic-like drugs are known to induce parkinsonism, which may reveal underlying Parkinson disease (PD) in some cases. We assessed the long-term risk of developing PD after past exposure to these drugs, in a 15-year prospective population-based elderly cohort study.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used the Cox proportional hazards model to assess the relation between past exposure to neuroleptics and the risk of developing incident PD. All incident cases of parkinsonism were identified by standardized procedure and validated by a committee of experts.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 2,991 subjects followed, 117 developed parkinsonism and 43 developed probable PD during follow-up, of whom 22.2% and 32.6%, respectively, had been exposed to neuroleptics, compared to 16.6% for subjects without parkinsonism. About a third of subjects presented transient parkinsonism during drug exposure. After adjustment for gender and past occupation, past exposure to neuroleptics was associated with incident PD (relative risk, 3.16; 95% confidence interval [CI], 1.65-6.04). The relative risk was 3.65 (95% CI, 1.41-9.45) for benzamides and 2.59 (95% CI, 1.23-5.43) for phenothiazines. The population-attributable fraction of the risk for developing PD was 8.2% for benzamides and 12.2% for phenothiazines.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In a French elderly cohort, the risk of probable PD was increased by 3.2-fold after exposure to neuroleptics. This finding suggests the necessity of limiting the use of such drugs in elderly people.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Foubert-Samier</LastName>
<ForeName>Alexandra</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>INSERM Unit 897, Bordeaux, France. alexandra.foubert@isped.u-bordeaux2.fr</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Helmer</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Perez</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Le Goff</LastName>
<ForeName>Mélanie</ForeName>
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<Author ValidYN="Y"><LastName>Auriacombe</LastName>
<ForeName>Sophie</ForeName>
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<Author ValidYN="Y"><LastName>Elbaz</LastName>
<ForeName>Alexis</ForeName>
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<Author ValidYN="Y"><LastName>Dartigues</LastName>
<ForeName>Jean-François</ForeName>
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<Author ValidYN="Y"><LastName>Tison</LastName>
<ForeName>François</ForeName>
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<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>09</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Neurology</MedlineTA>
<NlmUniqueID>0401060</NlmUniqueID>
<ISSNLinking>0028-3878</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014150">Antipsychotic Agents</NameOfSubstance>
</Chemical>
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<CitationSubset>AIM</CitationSubset>
<CitationSubset>IM</CitationSubset>
<CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Evid Based Ment Health. 2013 Feb;16(1):27</RefSource>
<PMID Version="1">23241755</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014150" MajorTopicYN="N">Antipsychotic Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012306" MajorTopicYN="N">Risk</DescriptorName>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.

Past exposure to neuroleptic drugs and risk of Parkinson disease in an elderly cohort.

Source :

English descriptors

Abstract

Links to Exploration step

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