Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia.
Identifieur interne : 000781 ( PubMed/Corpus ); précédent : 000780; suivant : 000782Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia.
Auteurs : Laetitia Barbin ; Christophe Leux ; Paul Sauleau ; Claire Meyniel ; Jean-Michel Nguyen ; Yann Pereon ; Philippe DamierSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2013.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (adverse effects), Dyskinesia, Drug-Induced (physiopathology), Female, Humans, Levodopa (adverse effects), Male, Middle Aged, Motor Cortex (drug effects), Motor Cortex (physiopathology), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Transcranial Magnetic Stimulation.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug effects : Motor Cortex.
- drug therapy : Parkinson Disease.
- physiopathology : Dyskinesia, Drug-Induced, Motor Cortex, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Transcranial Magnetic Stimulation.
Abstract
Levodopa-induced dyskinesia in patients with Parkinson's disease (PD) has been shown to be associated with an abnormal plasticity in the motor cortex. We investigated whether changes in the excitability of inhibitory and excitatory motor circuits could underlie maladaptive mechanisms associated with dyskinesia.
DOI: 10.1016/j.parkreldis.2012.08.012
PubMed: 23000298
Links to Exploration step
pubmed:23000298Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia.</title>
<author><name sortKey="Barbin, Laetitia" sort="Barbin, Laetitia" uniqKey="Barbin L" first="Laetitia" last="Barbin">Laetitia Barbin</name>
<affiliation><nlm:affiliation>INSERM, CIC 0004, Nantes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leux, Christophe" sort="Leux, Christophe" uniqKey="Leux C" first="Christophe" last="Leux">Christophe Leux</name>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
</author>
<author><name sortKey="Meyniel, Claire" sort="Meyniel, Claire" uniqKey="Meyniel C" first="Claire" last="Meyniel">Claire Meyniel</name>
</author>
<author><name sortKey="Nguyen, Jean Michel" sort="Nguyen, Jean Michel" uniqKey="Nguyen J" first="Jean-Michel" last="Nguyen">Jean-Michel Nguyen</name>
</author>
<author><name sortKey="Pereon, Yann" sort="Pereon, Yann" uniqKey="Pereon Y" first="Yann" last="Pereon">Yann Pereon</name>
</author>
<author><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2013">2013</date>
<idno type="RBID">pubmed:23000298</idno>
<idno type="pmid">23000298</idno>
<idno type="doi">10.1016/j.parkreldis.2012.08.012</idno>
<idno type="wicri:Area/PubMed/Corpus">000781</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000781</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia.</title>
<author><name sortKey="Barbin, Laetitia" sort="Barbin, Laetitia" uniqKey="Barbin L" first="Laetitia" last="Barbin">Laetitia Barbin</name>
<affiliation><nlm:affiliation>INSERM, CIC 0004, Nantes, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Leux, Christophe" sort="Leux, Christophe" uniqKey="Leux C" first="Christophe" last="Leux">Christophe Leux</name>
</author>
<author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name>
</author>
<author><name sortKey="Meyniel, Claire" sort="Meyniel, Claire" uniqKey="Meyniel C" first="Claire" last="Meyniel">Claire Meyniel</name>
</author>
<author><name sortKey="Nguyen, Jean Michel" sort="Nguyen, Jean Michel" uniqKey="Nguyen J" first="Jean-Michel" last="Nguyen">Jean-Michel Nguyen</name>
</author>
<author><name sortKey="Pereon, Yann" sort="Pereon, Yann" uniqKey="Pereon Y" first="Yann" last="Pereon">Yann Pereon</name>
</author>
<author><name sortKey="Damier, Philippe" sort="Damier, Philippe" uniqKey="Damier P" first="Philippe" last="Damier">Philippe Damier</name>
</author>
</analytic>
<series><title level="j">Parkinsonism & related disorders</title>
<idno type="eISSN">1873-5126</idno>
<imprint><date when="2013" type="published">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Antiparkinson Agents (adverse effects)</term>
<term>Dyskinesia, Drug-Induced (physiopathology)</term>
<term>Female</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Cortex (drug effects)</term>
<term>Motor Cortex (physiopathology)</term>
<term>Parkinson Disease (drug therapy)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Transcranial Magnetic Stimulation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term>
<term>Levodopa</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
<term>Motor Cortex</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Transcranial Magnetic Stimulation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Levodopa-induced dyskinesia in patients with Parkinson's disease (PD) has been shown to be associated with an abnormal plasticity in the motor cortex. We investigated whether changes in the excitability of inhibitory and excitatory motor circuits could underlie maladaptive mechanisms associated with dyskinesia.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23000298</PMID>
<DateCreated><Year>2013</Year>
<Month>02</Month>
<Day>12</Day>
</DateCreated>
<DateCompleted><Year>2013</Year>
<Month>08</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>2</Issue>
<PubDate><Year>2013</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Parkinsonism & related disorders</Title>
<ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation>
</Journal>
<ArticleTitle>Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia.</ArticleTitle>
<Pagination><MedlinePgn>165-70</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2012.08.012</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1353-8020(12)00337-9</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Levodopa-induced dyskinesia in patients with Parkinson's disease (PD) has been shown to be associated with an abnormal plasticity in the motor cortex. We investigated whether changes in the excitability of inhibitory and excitatory motor circuits could underlie maladaptive mechanisms associated with dyskinesia.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Using single and paired transcranial magnetic stimulation (TMS), we studied motor threshold, silent period (SP) duration, intracortical facilitation (ICF), short intracortical inhibition (SICI) and low- and high-intensity long intracortical inhibition (LICI) in 10 dyskinetic and 10 non-dyskinetic patients, matched for disease and treatment duration, before (OFF state) and after (ON state) levodopa, and in 10 healthy controls.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">In the OFF state, the two groups of patients showed similar motor cortex excitability with a reduced SICI compared to controls. LICI was weaker and increasing stimulation intensity had a lower effect on SP duration in dyskinetic patients than in controls. In dyskinetic patients, in contrast to non-dyskinetic patients, levodopa failed to increase SICI and SP duration, and potentiated to a lesser extent the effect of increasing the stimulation intensity on LICI. Although levodopa improved motor symptoms to a similar extent in both dyskinetic and non-dyskinetic patients, it failed to activate effectively the excitability of the inhibitory systems in dyskinetic patients.</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">These findings suggest that dyskinesia is associated with an abnormal effect of levodopa on cortical motor inhibitory circuits.</AbstractText>
<CopyrightInformation>Copyright © 2012 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Barbin</LastName>
<ForeName>Laetitia</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>INSERM, CIC 0004, Nantes, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leux</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sauleau</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Meyniel</LastName>
<ForeName>Claire</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nguyen</LastName>
<ForeName>Jean-Michel</ForeName>
<Initials>JM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pereon</LastName>
<ForeName>Yann</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Damier</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>09</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Parkinsonism Relat Disord</MedlineTA>
<NlmUniqueID>9513583</NlmUniqueID>
<ISSNLinking>1353-8020</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000978">Antiparkinson Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>46627O600J</RegistryNumber>
<NameOfSubstance UI="D007980">Levodopa</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000978" MajorTopicYN="N">Antiparkinson Agents</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004409" MajorTopicYN="N">Dyskinesia, Drug-Induced</DescriptorName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName>
<QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009044" MajorTopicYN="N">Motor Cortex</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050781" MajorTopicYN="N">Transcranial Magnetic Stimulation</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year>
<Month>04</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2012</Year>
<Month>07</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2012</Year>
<Month>08</Month>
<Day>30</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>9</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>9</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>8</Month>
<Day>10</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">23000298</ArticleId>
<ArticleId IdType="pii">S1353-8020(12)00337-9</ArticleId>
<ArticleId IdType="doi">10.1016/j.parkreldis.2012.08.012</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000781 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000781 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:23000298 |texte= Non-homogeneous effect of levodopa on inhibitory circuits in Parkinson's disease and dyskinesia. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:23000298" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonFranceV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |