Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study.
Identifieur interne : 000738 ( PubMed/Corpus ); précédent : 000737; suivant : 000739Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study.
Auteurs : Caroline Moreau ; Arnaud Delval ; Vincent Tiffreau ; Luc Defebvre ; Kathy Dujardin ; Alain Duhamel ; Gregory Petyt ; Claude Hossein-Foucher ; David Blum ; Bernard Sablonnière ; Susanna Schraen ; Delphine Allorge ; Alain Destée ; Régis Bordet ; David DevosSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2013.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Antiparkinson Agents (adverse effects), Antiparkinson Agents (therapeutic use), Disability Evaluation, Double-Blind Method, Dyskinesia, Drug-Induced (prevention & control), Female, Gait Disorders, Neurologic (drug therapy), Gait Disorders, Neurologic (etiology), Humans, Levodopa (adverse effects), Levodopa (therapeutic use), Male, Memantine (adverse effects), Memantine (therapeutic use), Middle Aged, Parkinson Disease (drug therapy), Pilot Projects, Sample Size.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa, Memantine.
- chemical , therapeutic use : Antiparkinson Agents, Levodopa, Memantine.
- drug therapy : Gait Disorders, Neurologic, Parkinson Disease.
- etiology : Gait Disorders, Neurologic.
- prevention & control : Dyskinesia, Drug-Induced.
- Aged, Aged, 80 and over, Disability Evaluation, Double-Blind Method, Female, Humans, Male, Middle Aged, Pilot Projects, Sample Size.
Abstract
Given that memantine is thought to decrease N-methyl-D-aspartic-acid-related (NMDA) glutamatergic hyperactivity and improve locomotion in rats, we sought to assess the drug's impact on axial symptoms in advanced Parkinson's disease (PD).
DOI: 10.1136/jnnp-2012-303182
PubMed: 23077087
Links to Exploration step
pubmed:23077087Le document en format XML
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<term>Female</term>
<term>Gait Disorders, Neurologic (drug therapy)</term>
<term>Gait Disorders, Neurologic (etiology)</term>
<term>Humans</term>
<term>Levodopa (adverse effects)</term>
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<term>Male</term>
<term>Memantine (adverse effects)</term>
<term>Memantine (therapeutic use)</term>
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<front><div type="abstract" xml:lang="en">Given that memantine is thought to decrease N-methyl-D-aspartic-acid-related (NMDA) glutamatergic hyperactivity and improve locomotion in rats, we sought to assess the drug's impact on axial symptoms in advanced Parkinson's disease (PD).</div>
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<Title>Journal of neurology, neurosurgery, and psychiatry</Title>
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<ArticleTitle>Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Given that memantine is thought to decrease N-methyl-D-aspartic-acid-related (NMDA) glutamatergic hyperactivity and improve locomotion in rats, we sought to assess the drug's impact on axial symptoms in advanced Parkinson's disease (PD).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a 90-day, randomised, double-blind, study with two parallel arms: 20 mg/day memantine versus placebo (ClinicalTrials.gov:NCT01108029). The main inclusion criterion was the presence of a severe gait disorder and an abnormal, forward-leaning stance. The following parameters were analysed under standardised conditions before and after acute administration of L-dopa: gait (stride length as primary criterion), the United-Parkinson's-Disease-Rating-Scale (UPDRS) motor score and its axial subscore, the hypertonia and strength of the axial extensors and flexors (isokinetic dynamometer), the Dyskinesia Rating Scale score (DRS) and its axial subscore.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Twenty-five patients were included. The memantine and placebo group did not differ significantly in terms of stride length. However, in the memantine group, we observed significantly better results (vs placebo) for the overall UPDRS score (F(1,21)=4.9; p=0.039(-1)) and its axial subscore (F(1,21)=7.2; p=0.014(-1.1)), axial hypertonia, the axial and overall DRS and axial strength.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Memantine treatment was associated with lower axial motor symptom and dyskinesia scores but did not improve gait. These benefits must be confirmed in a broader population of patients.</AbstractText>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Brain. 2000 Sep;123 ( Pt 9):1767-83</RefSource>
<PMID Version="1">10960043</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2009 Jun 15;24(8):1176-82</RefSource>
<PMID Version="1">19412964</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol. 2001 Nov;248(11):950-8</RefSource>
<PMID Version="1">11757958</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Behav Brain Res. 2004 May 5;151(1-2):17-23</RefSource>
<PMID Version="1">15084417</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Arzneimittelforschung. 1977 Jul;27(7):1487-9</RefSource>
<PMID Version="1">332193</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Dtsch Med Wochenschr. 1984 Jun 22;109(25):987-90</RefSource>
<PMID Version="1">6734455</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52</RefSource>
<PMID Version="1">2841426</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Transm Park Dis Dement Sect. 1992;4:277-82</RefSource>
<PMID Version="1">1388698</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neural Transm Gen Sect. 1994;98(1):57-67</RefSource>
<PMID Version="1">7710739</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Psychopharmacology (Berl). 1995 May;119(1):55-65</RefSource>
<PMID Version="1">7675950</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1998 Sep;44(3 Suppl 1):S175-88</RefSource>
<PMID Version="1">9749591</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Neuropharmacol. 1999 Sep-Oct;22(5):273-6</RefSource>
<PMID Version="1">10516877</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Curr Opin Pharmacol. 2006 Feb;6(1):61-7</RefSource>
<PMID Version="1">16368266</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2007 May;78(5):470-5</RefSource>
<PMID Version="1">17098845</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Bull Exp Biol Med. 2000 Jul;130(7):629-32</RefSource>
<PMID Version="1">11140570</PMID>
</CommentsCorrections>
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