A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.
Identifieur interne : 000719 ( PubMed/Corpus ); précédent : 000718; suivant : 000720A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.
Auteurs : Alice Poisson ; Bénédicte Ballanger ; Elise Metereau ; Jérome Redouté ; Danielle Ibarolla ; Jean-Christophe Comte ; Hélène Gervais Bernard ; Marie Vidailhet ; Emmanuel Broussolle ; Stéphane ThoboisSource :
- PloS one [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- complications : Dyskinesias, Parkinson Disease.
- physiopathology : Dyskinesias, Parkinson Disease.
- Aged, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Mirror movements correspond to involuntary movements observed in the limb contralateral to the one performing voluntary movement. They can be observed in Parkinson's disease (PD) but their pathophysiology remains unclear. The present study aims at identifying their neural correlates in PD using functional magnetic resonance imaging. Ten control subjects and 14-off drug patients with asymmetrical right-sided PD were included (8 with left-sided mirror movements during right-hand movements, and 6 without mirror movements). Between-group comparisons of BOLD signal were performed during right-hand movements and at rest (p<0.005 uncorrected). The comparison between PD patients with and without mirror movements showed that mirror movements were associated with an overactivation of the insula, precuneus/posterior cingulate cortex bilaterally and of the left inferior frontal cortex and with a deactivation of the right dorsolateral prefrontal cortex, medial prefrontal cortex, and pre-supplementary motor area and occipital cortex. These data suggest that mirror movements in Parkinson's disease are promoted by: 1- a deactivation of the non-mirroring inhibitory network (dorsolateral prefrontal cortex, pre-supplementary motor area); 2- an overactivation of prokinetic areas (notably the insula). The concomitant overactivation of a proactive inhibitory network (including the posterior cingulate cortex and precuneus) could reflect a compensatory inhibition of mirror movements.
DOI: 10.1371/journal.pone.0066910
PubMed: 23825583
Links to Exploration step
pubmed:23825583Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.</title><author><name sortKey="Poisson, Alice" sort="Poisson, Alice" uniqKey="Poisson A" first="Alice" last="Poisson">Alice Poisson</name><affiliation><nlm:affiliation>Université de Lyon, Faculté de Médecine Lyon Sud Charles Mérieux, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Bénédicte" last="Ballanger">Bénédicte Ballanger</name></author><author><name sortKey="Metereau, Elise" sort="Metereau, Elise" uniqKey="Metereau E" first="Elise" last="Metereau">Elise Metereau</name></author><author><name sortKey="Redoute, Jerome" sort="Redoute, Jerome" uniqKey="Redoute J" first="Jérome" last="Redouté">Jérome Redouté</name></author><author><name sortKey="Ibarolla, Danielle" sort="Ibarolla, Danielle" uniqKey="Ibarolla D" first="Danielle" last="Ibarolla">Danielle Ibarolla</name></author><author><name sortKey="Comte, Jean Christophe" sort="Comte, Jean Christophe" uniqKey="Comte J" first="Jean-Christophe" last="Comte">Jean-Christophe Comte</name></author><author><name sortKey="Bernard, Helene Gervais" sort="Bernard, Helene Gervais" uniqKey="Bernard H" first="Hélène Gervais" last="Bernard">Hélène Gervais Bernard</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23825583</idno><idno type="pmid">23825583</idno><idno type="doi">10.1371/journal.pone.0066910</idno><idno type="wicri:Area/PubMed/Corpus">000719</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000719</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.</title><author><name sortKey="Poisson, Alice" sort="Poisson, Alice" uniqKey="Poisson A" first="Alice" last="Poisson">Alice Poisson</name><affiliation><nlm:affiliation>Université de Lyon, Faculté de Médecine Lyon Sud Charles Mérieux, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ballanger, Benedicte" sort="Ballanger, Benedicte" uniqKey="Ballanger B" first="Bénédicte" last="Ballanger">Bénédicte Ballanger</name></author><author><name sortKey="Metereau, Elise" sort="Metereau, Elise" uniqKey="Metereau E" first="Elise" last="Metereau">Elise Metereau</name></author><author><name sortKey="Redoute, Jerome" sort="Redoute, Jerome" uniqKey="Redoute J" first="Jérome" last="Redouté">Jérome Redouté</name></author><author><name sortKey="Ibarolla, Danielle" sort="Ibarolla, Danielle" uniqKey="Ibarolla D" first="Danielle" last="Ibarolla">Danielle Ibarolla</name></author><author><name sortKey="Comte, Jean Christophe" sort="Comte, Jean Christophe" uniqKey="Comte J" first="Jean-Christophe" last="Comte">Jean-Christophe Comte</name></author><author><name sortKey="Bernard, Helene Gervais" sort="Bernard, Helene Gervais" uniqKey="Bernard H" first="Hélène Gervais" last="Bernard">Hélène Gervais Bernard</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Broussolle, Emmanuel" sort="Broussolle, Emmanuel" uniqKey="Broussolle E" first="Emmanuel" last="Broussolle">Emmanuel Broussolle</name></author><author><name sortKey="Thobois, Stephane" sort="Thobois, Stephane" uniqKey="Thobois S" first="Stéphane" last="Thobois">Stéphane Thobois</name></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Dyskinesias (complications)</term><term>Dyskinesias (physiopathology)</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mirror movements correspond to involuntary movements observed in the limb contralateral to the one performing voluntary movement. They can be observed in Parkinson's disease (PD) but their pathophysiology remains unclear. The present study aims at identifying their neural correlates in PD using functional magnetic resonance imaging. Ten control subjects and 14-off drug patients with asymmetrical right-sided PD were included (8 with left-sided mirror movements during right-hand movements, and 6 without mirror movements). Between-group comparisons of BOLD signal were performed during right-hand movements and at rest (p<0.005 uncorrected). The comparison between PD patients with and without mirror movements showed that mirror movements were associated with an overactivation of the insula, precuneus/posterior cingulate cortex bilaterally and of the left inferior frontal cortex and with a deactivation of the right dorsolateral prefrontal cortex, medial prefrontal cortex, and pre-supplementary motor area and occipital cortex. These data suggest that mirror movements in Parkinson's disease are promoted by: 1- a deactivation of the non-mirroring inhibitory network (dorsolateral prefrontal cortex, pre-supplementary motor area); 2- an overactivation of prokinetic areas (notably the insula). The concomitant overactivation of a proactive inhibitory network (including the posterior cingulate cortex and precuneus) could reflect a compensatory inhibition of mirror movements.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23825583</PMID><DateCreated><Year>2013</Year><Month>07</Month><Day>04</Day></DateCreated><DateCompleted><Year>2014</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>23</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>6</Issue><PubDate><Year>2013</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>A functional magnetic resonance imaging study of pathophysiological changes responsible for mirror movements in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>e66910</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0066910</ELocationID><Abstract><AbstractText>Mirror movements correspond to involuntary movements observed in the limb contralateral to the one performing voluntary movement. They can be observed in Parkinson's disease (PD) but their pathophysiology remains unclear. The present study aims at identifying their neural correlates in PD using functional magnetic resonance imaging. Ten control subjects and 14-off drug patients with asymmetrical right-sided PD were included (8 with left-sided mirror movements during right-hand movements, and 6 without mirror movements). Between-group comparisons of BOLD signal were performed during right-hand movements and at rest (p<0.005 uncorrected). The comparison between PD patients with and without mirror movements showed that mirror movements were associated with an overactivation of the insula, precuneus/posterior cingulate cortex bilaterally and of the left inferior frontal cortex and with a deactivation of the right dorsolateral prefrontal cortex, medial prefrontal cortex, and pre-supplementary motor area and occipital cortex. These data suggest that mirror movements in Parkinson's disease are promoted by: 1- a deactivation of the non-mirroring inhibitory network (dorsolateral prefrontal cortex, pre-supplementary motor area); 2- an overactivation of prokinetic areas (notably the insula). The concomitant overactivation of a proactive inhibitory network (including the posterior cingulate cortex and precuneus) could reflect a compensatory inhibition of mirror movements.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Poisson</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université de Lyon, Faculté de Médecine Lyon Sud Charles Mérieux, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballanger</LastName><ForeName>Bénédicte</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Metereau</LastName><ForeName>Elise</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Redouté</LastName><ForeName>Jérome</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ibarolla</LastName><ForeName>Danielle</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Comte</LastName><ForeName>Jean-Christophe</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Bernard</LastName><ForeName>Hélène Gervais</ForeName><Initials>HG</Initials></Author><Author ValidYN="Y"><LastName>Vidailhet</LastName><ForeName>Marie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Broussolle</LastName><ForeName>Emmanuel</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Thobois</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>06</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1978 Nov;28(11):1152-7</RefSource><PMID Version="1">568735</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurol Neurosurg Psychiatry. 2003 Sep;74(9):1352-3</RefSource><PMID Version="1">12933961</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1988 Jan;38(1):59-63</RefSource><PMID Version="1">3336465</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Ann Neurol. 1991 Jan;29(1):63-71</RefSource><PMID Version="1">1996881</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cortex. 1996 Dec;32(4):679-91</RefSource><PMID Version="1">8954246</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Brain Res Rev. 1996 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Version="1">6716131</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020820" MajorTopicYN="N">Dyskinesias</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="Y">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC3692538</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>05</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>7</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId 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