The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease.
Identifieur interne : 000713 ( PubMed/Corpus ); précédent : 000712; suivant : 000714The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease.
Auteurs : Daniel García-Lorenzo ; Clarisse Longo-Dos Santos ; Claire Ewenczyk ; Smaranda Leu-Semenescu ; Cecile Gallea ; Graziella Quattrocchi ; Patricia Pita Lobo ; Cyril Poupon ; Habib Benali ; Isabelle Arnulf ; Marie Vidailhet ; Stéphane LehericySource :
- Brain : a journal of neurology [ 1460-2156 ] ; 2013.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Brain Mapping, Electroencephalography, Electromyography, Female, Humans, Image Processing, Computer-Assisted, Locus Coeruleus (metabolism), Locus Coeruleus (pathology), Magnetic Resonance Imaging, Male, Melanins (metabolism), Middle Aged, Neurologic Examination, Parkinson Disease (complications), Polysomnography, REM Sleep Behavior Disorder (etiology), REM Sleep Behavior Disorder (pathology), Regression Analysis, Retrospective Studies, Video Recording, Young Adult.
- MESH :
- chemical , metabolism : Melanins.
- complications : Parkinson Disease.
- etiology : REM Sleep Behavior Disorder.
- metabolism : Locus Coeruleus.
- pathology : Locus Coeruleus, REM Sleep Behavior Disorder.
- Adolescent, Adult, Aged, Brain Mapping, Electroencephalography, Electromyography, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Neurologic Examination, Polysomnography, Regression Analysis, Retrospective Studies, Video Recording, Young Adult.
Abstract
In Parkinson's disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson's disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson's disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson's disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson's disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson's disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson's disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson's disease pathology to predict the occurrence of Parkinson's disease.
DOI: 10.1093/brain/awt152
PubMed: 23801736
Links to Exploration step
pubmed:23801736Le document en format XML
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Quattrocchi</name></author><author><name sortKey="Pita Lobo, Patricia" sort="Pita Lobo, Patricia" uniqKey="Pita Lobo P" first="Patricia" last="Pita Lobo">Patricia Pita Lobo</name></author><author><name sortKey="Poupon, Cyril" sort="Poupon, Cyril" uniqKey="Poupon C" first="Cyril" last="Poupon">Cyril Poupon</name></author><author><name sortKey="Benali, Habib" sort="Benali, Habib" uniqKey="Benali H" first="Habib" last="Benali">Habib Benali</name></author><author><name sortKey="Arnulf, Isabelle" sort="Arnulf, Isabelle" uniqKey="Arnulf I" first="Isabelle" last="Arnulf">Isabelle Arnulf</name></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stéphane" last="Lehericy">Stéphane Lehericy</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno 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type="chemical" qualifier="metabolism" xml:lang="en"><term>Melanins</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Locus Coeruleus</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Locus Coeruleus</term><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Electroencephalography</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Neurologic Examination</term><term>Polysomnography</term><term>Regression Analysis</term><term>Retrospective Studies</term><term>Video Recording</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson's disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson's disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson's disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson's disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson's disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson's disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson's disease pathology to predict the occurrence of Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23801736</PMID><DateCreated><Year>2013</Year><Month>06</Month><Day>26</Day></DateCreated><DateCompleted><Year>2013</Year><Month>08</Month><Day>29</Day></DateCompleted><DateRevised><Year>2015</Year><Month>04</Month><Day>23</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2156</ISSN><JournalIssue CitedMedium="Internet"><Volume>136</Volume><Issue>Pt 7</Issue><PubDate><Year>2013</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Brain : a journal of neurology</Title><ISOAbbreviation>Brain</ISOAbbreviation></Journal><ArticleTitle>The coeruleus/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>2120-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/brain/awt152</ELocationID><Abstract><AbstractText>In Parkinson's disease, rapid eye movement sleep behaviour disorder is an early non-dopaminergic syndrome with nocturnal violence and increased muscle tone during rapid eye movement sleep that can precede Parkinsonism by several years. The neuronal origin of rapid eye movement sleep behaviour disorder in Parkinson's disease is not precisely known; however, the locus subcoeruleus in the brainstem has been implicated as this structure blocks muscle tone during normal rapid eye movement sleep in animal models and can be damaged in Parkinson's disease. Here, we studied the integrity of the locus coeruleus/subcoeruleus complex in patients with Parkinson's disease using combined neuromelanin-sensitive, structural and diffusion magnetic resonance imaging approaches. We compared 24 patients with Parkinson's disease and rapid eye movement sleep behaviour disorder, 12 patients without rapid eye movement sleep behaviour disorder and 19 age- and gender-matched healthy volunteers. All subjects underwent clinical examination and characterization of rapid eye movement sleep using video-polysomnography and multimodal imaging at 3 T. Using neuromelanin-sensitive imaging, reduced signal intensity was evident in the locus coeruleus/subcoeruleus area in patients with Parkinson's disease that was more marked in patients with than those without rapid eye movement sleep behaviour disorder. Reduced signal intensity correlated with the percentage of abnormally increased muscle tone during rapid eye movement sleep. The results confirmed that this complex is affected in Parkinson's disease and showed a gradual relationship between damage to this structure, presumably the locus subcoeruleus, and abnormal muscle tone during rapid eye movement sleep, which is the cardinal marker of rapid eye movement sleep behaviour disorder. In longitudinal studies, the technique may also provide early markers of non-dopaminergic Parkinson's disease pathology to predict the occurrence of Parkinson's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>García-Lorenzo</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut du Cerveau et de Moelle épinière, Centre de Neuroimagerie de Recherche, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Longo-Dos Santos</LastName><ForeName>Clarisse</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Ewenczyk</LastName><ForeName>Claire</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Leu-Semenescu</LastName><ForeName>Smaranda</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Gallea</LastName><ForeName>Cecile</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Quattrocchi</LastName><ForeName>Graziella</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Pita Lobo</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Poupon</LastName><ForeName>Cyril</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Benali</LastName><ForeName>Habib</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Arnulf</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Vidailhet</LastName><ForeName>Marie</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Lehericy</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. 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