Apathy and impaired emotional facial recognition networks overlap in Parkinson's disease: a PET study with conjunction analyses.
Identifieur interne : 000499 ( PubMed/Corpus ); précédent : 000498; suivant : 000500Apathy and impaired emotional facial recognition networks overlap in Parkinson's disease: a PET study with conjunction analyses.
Auteurs : Gabriel Robert ; Florence Le Jeune ; Thibault Dondaine ; Sophie Drapier ; Julie Péron ; Clément Lozachmeur ; Paul Sauleau ; Jean-François Houvenaghel ; David Travers ; Bruno Millet ; Marc Vérin ; Dominique DrapierSource :
- Journal of neurology, neurosurgery, and psychiatry [ 1468-330X ] ; 2014.
English descriptors
- KwdEn :
- Aged, Apathy (physiology), Brain Mapping, Facial Expression, Fluorodeoxyglucose F18, Frontal Lobe (physiopathology), Gyrus Cinguli (physiopathology), Humans, Image Processing, Computer-Assisted, Middle Aged, Parkinson Disease (physiopathology), Parkinson Disease (psychology), Positron-Emission Tomography, Recognition (Psychology) (physiology).
- MESH :
- chemical : Fluorodeoxyglucose F18.
- physiology : Apathy, Recognition (Psychology).
- physiopathology : Frontal Lobe, Gyrus Cinguli, Parkinson Disease.
- psychology : Parkinson Disease.
- Aged, Brain Mapping, Facial Expression, Humans, Image Processing, Computer-Assisted, Middle Aged, Positron-Emission Tomography.
Abstract
Apathy is a disabling non-motor symptom that is frequently observed in Parkinson's disease (PD). Its description and physiopathology suggest that it is partially mediated by emotional impairment, but this research issue has never been addressed at a clinical and metabolic level. We therefore conducted a metabolic study using (18)fluorodeoxyglucose positron emission tomography ((18)FDG PET) in 36 PD patients without depression and dementia. Apathy was assessed on the Apathy Evaluation Scale (AES), and emotional facial recognition (EFR) performances (ie, percentage of correct responses) were calculated for each patient. Confounding factors such as age, antiparkinsonian and antidepressant medication, global cognitive functions and depressive symptoms were controlled for. We found a significant negative correlation between AES scores and performances on the EFR task. The apathy network was characterised by increased metabolism within the left posterior cingulate (PC) cortex (Brodmann area (BA) 31). The impaired EFR network was characterised by decreased metabolism within the bilateral PC gyrus (BA 31), right superior frontal gyrus (BAs 10, 9 and 6) and left superior frontal gyrus (BA 10 and 11). By applying conjunction analyses to both networks, we identified the right premotor cortex (BA 6), right orbitofrontal cortex (BA 10), left middle frontal gyrus (BA 8) and left posterior cingulate gyrus (BA 31) as the structures supporting the association between apathy and impaired EFR. These results confirm that apathy in PD is partially mediated by impaired EFR, opening up new prospects for alleviating apathy in PD, such as emotional rehabilitation.
DOI: 10.1136/jnnp-2013-307025
PubMed: 24403280
Links to Exploration step
pubmed:24403280Le document en format XML
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Jeune">Florence Le Jeune</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Nuclear Medicine, Rennes University Hospital, Eugene Marquis Hospital Centre, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dondaine, Thibault" sort="Dondaine, Thibault" uniqKey="Dondaine T" first="Thibault" last="Dondaine">Thibault Dondaine</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Drapier, Sophie" sort="Drapier, Sophie" uniqKey="Drapier S" first="Sophie" last="Drapier">Sophie Drapier</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Peron, Julie" sort="Peron, Julie" uniqKey="Peron J" first="Julie" last="Péron">Julie Péron</name><affiliation><nlm:affiliation>Neuroscience of Emotion and Affective Dynamics lab, Swiss Center for Affective Sciences, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Lozachmeur, Clement" sort="Lozachmeur, Clement" uniqKey="Lozachmeur C" first="Clément" last="Lozachmeur">Clément Lozachmeur</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sauleau, Paul" sort="Sauleau, Paul" uniqKey="Sauleau P" first="Paul" last="Sauleau">Paul Sauleau</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Houvenaghel, Jean Francois" sort="Houvenaghel, Jean Francois" uniqKey="Houvenaghel J" first="Jean-François" last="Houvenaghel">Jean-François Houvenaghel</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Travers, David" sort="Travers, David" uniqKey="Travers D" first="David" last="Travers">David Travers</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Millet, Bruno" sort="Millet, Bruno" uniqKey="Millet B" first="Bruno" last="Millet">Bruno Millet</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Verin, Marc" sort="Verin, Marc" uniqKey="Verin M" first="Marc" last="Vérin">Marc Vérin</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Drapier, Dominique" sort="Drapier, Dominique" uniqKey="Drapier D" first="Dominique" last="Drapier">Dominique Drapier</name><affiliation><nlm:affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of neurology, neurosurgery, and psychiatry</title><idno type="eISSN">1468-330X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Apathy (physiology)</term><term>Brain Mapping</term><term>Facial Expression</term><term>Fluorodeoxyglucose F18</term><term>Frontal Lobe (physiopathology)</term><term>Gyrus Cinguli (physiopathology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (psychology)</term><term>Positron-Emission Tomography</term><term>Recognition (Psychology) (physiology)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Fluorodeoxyglucose F18</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Apathy</term><term>Recognition (Psychology)</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Frontal Lobe</term><term>Gyrus Cinguli</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Brain Mapping</term><term>Facial Expression</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Middle Aged</term><term>Positron-Emission Tomography</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Apathy is a disabling non-motor symptom that is frequently observed in Parkinson's disease (PD). Its description and physiopathology suggest that it is partially mediated by emotional impairment, but this research issue has never been addressed at a clinical and metabolic level. We therefore conducted a metabolic study using (18)fluorodeoxyglucose positron emission tomography ((18)FDG PET) in 36 PD patients without depression and dementia. Apathy was assessed on the Apathy Evaluation Scale (AES), and emotional facial recognition (EFR) performances (ie, percentage of correct responses) were calculated for each patient. Confounding factors such as age, antiparkinsonian and antidepressant medication, global cognitive functions and depressive symptoms were controlled for. We found a significant negative correlation between AES scores and performances on the EFR task. The apathy network was characterised by increased metabolism within the left posterior cingulate (PC) cortex (Brodmann area (BA) 31). The impaired EFR network was characterised by decreased metabolism within the bilateral PC gyrus (BA 31), right superior frontal gyrus (BAs 10, 9 and 6) and left superior frontal gyrus (BA 10 and 11). By applying conjunction analyses to both networks, we identified the right premotor cortex (BA 6), right orbitofrontal cortex (BA 10), left middle frontal gyrus (BA 8) and left posterior cingulate gyrus (BA 31) as the structures supporting the association between apathy and impaired EFR. These results confirm that apathy in PD is partially mediated by impaired EFR, opening up new prospects for alleviating apathy in PD, such as emotional rehabilitation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24403280</PMID><DateCreated><Year>2014</Year><Month>09</Month><Day>11</Day></DateCreated><DateCompleted><Year>2014</Year><Month>11</Month><Day>03</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1468-330X</ISSN><JournalIssue CitedMedium="Internet"><Volume>85</Volume><Issue>10</Issue><PubDate><Year>2014</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of neurology, neurosurgery, and psychiatry</Title><ISOAbbreviation>J. Neurol. Neurosurg. Psychiatr.</ISOAbbreviation></Journal><ArticleTitle>Apathy and impaired emotional facial recognition networks overlap in Parkinson's disease: a PET study with conjunction analyses.</ArticleTitle><Pagination><MedlinePgn>1153-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/jnnp-2013-307025</ELocationID><Abstract><AbstractText>Apathy is a disabling non-motor symptom that is frequently observed in Parkinson's disease (PD). Its description and physiopathology suggest that it is partially mediated by emotional impairment, but this research issue has never been addressed at a clinical and metabolic level. We therefore conducted a metabolic study using (18)fluorodeoxyglucose positron emission tomography ((18)FDG PET) in 36 PD patients without depression and dementia. Apathy was assessed on the Apathy Evaluation Scale (AES), and emotional facial recognition (EFR) performances (ie, percentage of correct responses) were calculated for each patient. Confounding factors such as age, antiparkinsonian and antidepressant medication, global cognitive functions and depressive symptoms were controlled for. We found a significant negative correlation between AES scores and performances on the EFR task. The apathy network was characterised by increased metabolism within the left posterior cingulate (PC) cortex (Brodmann area (BA) 31). The impaired EFR network was characterised by decreased metabolism within the bilateral PC gyrus (BA 31), right superior frontal gyrus (BAs 10, 9 and 6) and left superior frontal gyrus (BA 10 and 11). By applying conjunction analyses to both networks, we identified the right premotor cortex (BA 6), right orbitofrontal cortex (BA 10), left middle frontal gyrus (BA 8) and left posterior cingulate gyrus (BA 31) as the structures supporting the association between apathy and impaired EFR. These results confirm that apathy in PD is partially mediated by impaired EFR, opening up new prospects for alleviating apathy in PD, such as emotional rehabilitation.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Robert</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Jeune</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Nuclear Medicine, Rennes University Hospital, Eugene Marquis Hospital Centre, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dondaine</LastName><ForeName>Thibault</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drapier</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Péron</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Neuroscience of Emotion and Affective Dynamics lab, Swiss Center for Affective Sciences, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lozachmeur</LastName><ForeName>Clément</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sauleau</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houvenaghel</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travers</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Millet</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vérin</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Neurology, Rennes University Hospital, Rennes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drapier</LastName><ForeName>Dominique</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Behavior and Basal Ganglia host team 4712, University of Rennes 1, Rennes, France Department of Psychiatry, Rennes University Hospital, Guillaume Régnier Hospital Centre, Rennes, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>01</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Neurol Neurosurg Psychiatry</MedlineTA><NlmUniqueID>2985191R</NlmUniqueID><ISSNLinking>0022-3050</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0Z5B2CJX4D</RegistryNumber><NameOfSubstance UI="D019788">Fluorodeoxyglucose F18</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Neurol Neurosurg Psychiatry. 2014 Oct;85(10):1061</RefSource><PMID Version="1">24403281</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057565" MajorTopicYN="N">Apathy</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001931" MajorTopicYN="N">Brain Mapping</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005149" MajorTopicYN="N">Facial Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019788" MajorTopicYN="N">Fluorodeoxyglucose F18</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005625" MajorTopicYN="N">Frontal Lobe</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006179" MajorTopicYN="N">Gyrus Cinguli</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D049268" MajorTopicYN="N">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021641" MajorTopicYN="N">Recognition (Psychology)</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Neuropsychiatry</Keyword><Keyword MajorTopicYN="N">Parkinson's Disease</Keyword><Keyword MajorTopicYN="N">Pet, Functional Imaging</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>1</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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