[Changes in olfaction during ageing and in certain neurodegenerative diseases: up-to-date].
Identifieur interne : 000446 ( PubMed/Corpus ); précédent : 000445; suivant : 000447[Changes in olfaction during ageing and in certain neurodegenerative diseases: up-to-date].
Auteurs : A-J Bianchi ; H. Guépet-Sordet ; P. ManckoundiaSource :
- La Revue de medecine interne [ 1768-3122 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aging (physiology), Alzheimer Disease (complications), Alzheimer Disease (physiopathology), Humans, Memory (physiology), Neurodegenerative Diseases (complications), Neurodegenerative Diseases (physiopathology), Olfaction Disorders (etiology), Olfaction Disorders (physiopathology), Parkinson Disease (complications), Parkinson Disease (physiopathology), Smell (physiology).
- MESH :
- complications : Alzheimer Disease, Neurodegenerative Diseases, Parkinson Disease.
- etiology : Olfaction Disorders.
- physiology : Aging, Memory, Smell.
- physiopathology : Alzheimer Disease, Neurodegenerative Diseases, Olfaction Disorders, Parkinson Disease.
- Aged, Aged, 80 and over, Humans.
Abstract
Olfaction is a complex sensory system, and increasing interest is being shown in the link between olfaction and cognition, notably in the elderly. In this literature review, we revisit the specific neurophysiological features of the olfactory system and odorants that lead to a durable olfactory memory and an emotional memory, for which the implicit component produces subconscious olfactory conditioning. Olfaction is known to affect cognitive abilities and mood. We also consider the impairment of olfactory function due to ageing and to neurodegenerative diseases, in particular Alzheimer's disease and Parkinson's disease, through anatomopathological changes in the peripheral and central olfactory structures. The high frequency of these olfactory disorders as well as their early occurrence in Alzheimer disease and Parkinson disease are in favour of their clinical detection in subjects suffering from these two neurodegenerative diseases. Finally, we analyse the impact of olfactory stimulation on cognitive performance and attention. Current observational data from studies in elderly patients with Alzheimer-type dementia are limited to multiple sensory stimulation methods, such as the Snoezelen method, and aromatherapy. These therapies have shown benefits for dementia-related mood and behaviour disorders in the short term, with few side effects. Since olfactory chemosensory stimulation may be beneficial, it may be proposed in patients with dementia, especially Alzheimer-type dementia, as a complementary or even alternative therapy to existing medical strategies.
DOI: 10.1016/j.revmed.2014.09.008
PubMed: 25304170
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Manckoundia</name><affiliation><nlm:affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot, CHU, BP 87 909, 2, rue Jules-Violle, 21079 Dijon cedex, France; Inserm U1093 motricité-plasticité : performance, dysfonctionnement, vieillissement et technologies d'optimisation, université de Bourgogne, BP 27877, 21078 Dijon cedex, France. 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Guépet-Sordet</name><affiliation><nlm:affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot, CHU, BP 87 909, 2, rue Jules-Violle, 21079 Dijon cedex, France.</nlm:affiliation></affiliation></author><author><name sortKey="Manckoundia, P" sort="Manckoundia, P" uniqKey="Manckoundia P" first="P" last="Manckoundia">P. Manckoundia</name><affiliation><nlm:affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot, CHU, BP 87 909, 2, rue Jules-Violle, 21079 Dijon cedex, France; Inserm U1093 motricité-plasticité : performance, dysfonctionnement, vieillissement et technologies d'optimisation, université de Bourgogne, BP 27877, 21078 Dijon cedex, France. Electronic address: patrick.manckoundia@chu-dijon.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">La Revue de medecine interne</title><idno type="eISSN">1768-3122</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Aging (physiology)</term><term>Alzheimer Disease (complications)</term><term>Alzheimer Disease (physiopathology)</term><term>Humans</term><term>Memory (physiology)</term><term>Neurodegenerative Diseases (complications)</term><term>Neurodegenerative Diseases (physiopathology)</term><term>Olfaction Disorders (etiology)</term><term>Olfaction Disorders (physiopathology)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (physiopathology)</term><term>Smell (physiology)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Aging</term><term>Memory</term><term>Smell</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term><term>Neurodegenerative Diseases</term><term>Olfaction Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Olfaction is a complex sensory system, and increasing interest is being shown in the link between olfaction and cognition, notably in the elderly. In this literature review, we revisit the specific neurophysiological features of the olfactory system and odorants that lead to a durable olfactory memory and an emotional memory, for which the implicit component produces subconscious olfactory conditioning. Olfaction is known to affect cognitive abilities and mood. We also consider the impairment of olfactory function due to ageing and to neurodegenerative diseases, in particular Alzheimer's disease and Parkinson's disease, through anatomopathological changes in the peripheral and central olfactory structures. The high frequency of these olfactory disorders as well as their early occurrence in Alzheimer disease and Parkinson disease are in favour of their clinical detection in subjects suffering from these two neurodegenerative diseases. Finally, we analyse the impact of olfactory stimulation on cognitive performance and attention. Current observational data from studies in elderly patients with Alzheimer-type dementia are limited to multiple sensory stimulation methods, such as the Snoezelen method, and aromatherapy. These therapies have shown benefits for dementia-related mood and behaviour disorders in the short term, with few side effects. Since olfactory chemosensory stimulation may be beneficial, it may be proposed in patients with dementia, especially Alzheimer-type dementia, as a complementary or even alternative therapy to existing medical strategies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25304170</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>22</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1768-3122</ISSN><JournalIssue CitedMedium="Internet"><Volume>36</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jan</Month></PubDate></JournalIssue><Title>La Revue de medecine interne</Title><ISOAbbreviation>Rev Med Interne</ISOAbbreviation></Journal><ArticleTitle>[Changes in olfaction during ageing and in certain neurodegenerative diseases: up-to-date].</ArticleTitle><Pagination><MedlinePgn>31-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.revmed.2014.09.008</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0248-8663(14)00643-2</ELocationID><Abstract><AbstractText>Olfaction is a complex sensory system, and increasing interest is being shown in the link between olfaction and cognition, notably in the elderly. In this literature review, we revisit the specific neurophysiological features of the olfactory system and odorants that lead to a durable olfactory memory and an emotional memory, for which the implicit component produces subconscious olfactory conditioning. Olfaction is known to affect cognitive abilities and mood. We also consider the impairment of olfactory function due to ageing and to neurodegenerative diseases, in particular Alzheimer's disease and Parkinson's disease, through anatomopathological changes in the peripheral and central olfactory structures. The high frequency of these olfactory disorders as well as their early occurrence in Alzheimer disease and Parkinson disease are in favour of their clinical detection in subjects suffering from these two neurodegenerative diseases. Finally, we analyse the impact of olfactory stimulation on cognitive performance and attention. Current observational data from studies in elderly patients with Alzheimer-type dementia are limited to multiple sensory stimulation methods, such as the Snoezelen method, and aromatherapy. These therapies have shown benefits for dementia-related mood and behaviour disorders in the short term, with few side effects. Since olfactory chemosensory stimulation may be beneficial, it may be proposed in patients with dementia, especially Alzheimer-type dementia, as a complementary or even alternative therapy to existing medical strategies.</AbstractText><CopyrightInformation>Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bianchi</LastName><ForeName>A-J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Service de soins de suite et de réadaptation gériatrique, hospices civils de Beaune, BP 40104, avenue Guigone-de-Salins, 21203 Beaune cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guépet-Sordet</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot, CHU, BP 87 909, 2, rue Jules-Violle, 21079 Dijon cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manckoundia</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Service de médecine interne gériatrie, hôpital de Champmaillot, CHU, BP 87 909, 2, rue Jules-Violle, 21079 Dijon cedex, France; Inserm U1093 motricité-plasticité : performance, dysfonctionnement, vieillissement et technologies d'optimisation, université de Bourgogne, BP 27877, 21078 Dijon cedex, France. 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