ParkinsonFranceV1, PubMed, Corpus, bibRecord, 000429

Clinical routine use of dopamine transporter imaging in 516 consecutive patients.

Identifieur interne : 000429 ( PubMed/Corpus ); précédent : 000428; suivant : 000430

Clinical routine use of dopamine transporter imaging in 516 consecutive patients.

Auteurs : Claire Thiriez ; Emmanuel Itti ; Gilles Fénelon ; Eva Evangelista ; Michel Meignan ; Pierre Cesaro ; Philippe Remy

Source :

Journal of neurology [ 1432-1459 ] ; 2015.

RBID : pubmed:25649832

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Brain (diagnostic imaging), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Humans, Longitudinal Studies, Male, Middle Aged, Movement Disorders (diagnostic imaging), Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Tropanes (pharmacokinetics), Young Adult.
MESH :
- chemical , metabolism : Dopamine Plasma Membrane Transport Proteins.
- diagnostic imaging : Brain, Movement Disorders.
- chemical , pharmacokinetics : Tropanes.
- Adult, Aged, Aged, 80 and over, Female, Humans, Longitudinal Studies, Male, Middle Aged, Retrospective Studies, Tomography, Emission-Computed, Single-Photon, Young Adult.

Abstract

[(123)I]-FP-CIT is a single photon emission computed tomography (SPECT) ligand showing in vivo the loss of dopaminergic terminals in the brain and is now available in the market. Despite several systematic studies in clinically inconclusive cases, the use of such imaging in clinical routine is scarcely reported. We analyzed 516 files of subjects with movement disorders who were consecutively examined using [(123)I]-FP-CIT scan and determined whether the use of imaging was appropriate and if it improved clinical diagnosis or care of the patient. In addition, we determined if appropriate use was related to subspecialties in Neurology, e.g., movement disorders' specialists vs. general neurologists, and if appropriate use was increasing over time. Among the 516 scans, 18% were in agreement with the license, 62% were classified as appropriate and 37% were considered inappropriate. A change of management was obvious in 60% of patients, but in 92% of those with an appropriate request vs. 13% of patients with an inappropriate request. Movement disorders' specialists had more appropriate requests than other practitioners. Eventually, comparing the first 100 vs. the last 100 quantified SPECT, performed more than 2.5 years apart, we found no difference for the appropriateness of the examination. The use of [(123)I]-FP-CIT imaging in clinical routine does not fit a restrictive license. An inappropriate use is seen in nearly 40% of cases, which reduces the real cost-effectiveness of the technique suggesting a need for continuing medical education on the topic.

DOI: 10.1007/s00415-014-7634-y
PubMed: 25649832

Links to Exploration step

pubmed:25649832

Le document en format XML

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<affiliation><nlm:affiliation>Centre Expert Parkinson, Service de neurologie, Hôpital Henri Mondor, 51 avenue du Maréchal de Lattre de Tassigny, 94010, Creteil Cedex, France, claire.thiriez@hmn.aphp.fr.</nlm:affiliation>
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<author><name sortKey="Itti, Emmanuel" sort="Itti, Emmanuel" uniqKey="Itti E" first="Emmanuel" last="Itti">Emmanuel Itti</name>
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<author><name sortKey="Fenelon, Gilles" sort="Fenelon, Gilles" uniqKey="Fenelon G" first="Gilles" last="Fénelon">Gilles Fénelon</name>
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<author><name sortKey="Evangelista, Eva" sort="Evangelista, Eva" uniqKey="Evangelista E" first="Eva" last="Evangelista">Eva Evangelista</name>
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<author><name sortKey="Meignan, Michel" sort="Meignan, Michel" uniqKey="Meignan M" first="Michel" last="Meignan">Michel Meignan</name>
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<author><name sortKey="Cesaro, Pierre" sort="Cesaro, Pierre" uniqKey="Cesaro P" first="Pierre" last="Cesaro">Pierre Cesaro</name>
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<front><div type="abstract" xml:lang="en">[(123)I]-FP-CIT is a single photon emission computed tomography (SPECT) ligand showing in vivo the loss of dopaminergic terminals in the brain and is now available in the market. Despite several systematic studies in clinically inconclusive cases, the use of such imaging in clinical routine is scarcely reported. We analyzed 516 files of subjects with movement disorders who were consecutively examined using [(123)I]-FP-CIT scan and determined whether the use of imaging was appropriate and if it improved clinical diagnosis or care of the patient. In addition, we determined if appropriate use was related to subspecialties in Neurology, e.g., movement disorders' specialists vs. general neurologists, and if appropriate use was increasing over time. Among the 516 scans, 18% were in agreement with the license, 62% were classified as appropriate and 37% were considered inappropriate. A change of management was obvious in 60% of patients, but in 92% of those with an appropriate request vs. 13% of patients with an inappropriate request. Movement disorders' specialists had more appropriate requests than other practitioners. Eventually, comparing the first 100 vs. the last 100 quantified SPECT, performed more than 2.5 years apart, we found no difference for the appropriateness of the examination. The use of [(123)I]-FP-CIT imaging in clinical routine does not fit a restrictive license. An inappropriate use is seen in nearly 40% of cases, which reduces the real cost-effectiveness of the technique suggesting a need for continuing medical education on the topic.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Clinical routine use of dopamine transporter imaging in 516 consecutive patients.

Clinical routine use of dopamine transporter imaging in 516 consecutive patients.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki